{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:28:46Z","timestamp":1790616526337,"version":"4.1.0"},"reference-count":41,"publisher":"Microbiology Society","issue":"11","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,29]]},"abstract":"<jats:p>\n                  <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.5609\" xlink:type=\"simple\">Streptococcus agalactiae<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> (group B <jats:italic>\n                     <jats:named-content content-type=\"genus\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.5605\" xlink:type=\"simple\">Streptococcus<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic>, GBS) has recently emerged as an important pathogen among adults. However, it is overlooked in this population, with all global efforts being directed towards its containment among pregnant women and neonates. This systematic review assessed the molecular epidemiology and compared how the lineages circulating among non-pregnant populations relate to those of pregnant and neonatal populations worldwide. A systematic search was performed across nine databases from 1 January 2000 up to and including 20 September 2021, with no language restrictions. The Joanna Briggs Institute (JBI) Prevalence Critical Appraisal Tool (PCAT) was used to assess the quality of included studies. The global population structure of GBS from the non-pregnant population was analysed using <jats:italic>in silico<\/jats:italic> typing and phylogenetic reconstruction tools. Twenty-four articles out of 13\u200a509 retrieved across 9 databases were eligible. Most studies were conducted in the World Health Organization European region (12\/24, 50\u200a%), followed by the Western Pacific region (6\/24, 25\u200a%) and the Americas region (6\/24, 25\u200a%). Serotype V (23%, 2310\/10240) and clonal complex (CC) 1 (29\u200a%, 2157\/7470) were the most frequent serotype and CC, respectively. The pilus island PI1\u202f:\u202fPI2A combination (29\u200a%, 3931\/13751) was the most prevalent surface protein gene, while the tetracycline resistance <jats:italic>tet<\/jats:italic>M (55\u200a%, 5892\/10624) was the leading antibiotic resistance gene. This study highlights that, given the common serotype distribution identified among non-pregnant populations (V, III, Ia, Ib, II and IV), vaccines including these six serotypes will provide broad coverage. The study indicates advanced molecular epidemiology studies, especially in resource-constrained settings for evidence-based decisions. Finally, the study shows that considering all at-risk populations in an inclusive approach is essential to ensure the sustainable containment of GBS.<\/jats:p>","DOI":"10.1099\/mgen.0.001140","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T15:17:07Z","timestamp":1701271027000},"source":"Crossref","is-referenced-by-count":10,"title":["Molecular epidemiology of Streptococcus agalactiae in non-pregnant populations: a systematic review"],"prefix":"10.1099","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3874-8175","authenticated-orcid":false,"given":"Luria Leslie","family":"Founou","sequence":"first","affiliation":[{"name":"Bioinformatics and Applied Machine Learning Research Unit, EDEN Biosciences Research Institute (EBRI), EDEN Foundation, Yaound\u00e9, Cameroon"},{"name":"Reproductive, Maternal, Newborn and Child Health (ReMARCH) Research Unit, Centre of Expertise and Biological Diagnostic of Cameroon Research Institute (CEDBCAM-RI), Yaound\u00e9, Cameroon"},{"name":"Antimicrobial Research Unit, School of Health Sciences, University of KwaZulu-Natal, Westville Campus, Durban, 4041, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzma Basit","family":"Khan","sequence":"additional","affiliation":[{"name":"Parasites and Microbes, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nubwa","family":"Medugu","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, National Hospital Abuja, Abuja, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana C. 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