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We investigated the contamination of a French small animal ICU with <jats:italic>A. baumannii<\/jats:italic>. We discovered repeated animal contamination by <jats:italic>A. baumannii<\/jats:italic>, and phylogenetic analysis traced contamination back to a potential foreign animal origin. Genomic analysis combined with antibiotic susceptibility testing revealed heteroresistance to penicillin and aminoglycoside mediated by insertion sequence dynamics and also suggest a potential cross-resistance to human-restricted piperacillin\u2013tazobactam combination. The <jats:italic>A. baumannii<\/jats:italic> isolates of the animal ICU belong to the International Clone 2 commonly found in human health settings. 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