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To test this, we analysed the relationship between secretor status, vaginal microbiota and gestational length in an ethnically diverse cohort of 302 pregnant women, including 82 who delivered preterm. <jats:italic>Lactobacillus gasseri<\/jats:italic> and <jats:italic>L. jensenii<\/jats:italic> were found to have distinct co-occurrence patterns with other microbial taxa in non-secretors. Moreover, non-secretors with <jats:italic>Lactobacillus<\/jats:italic> spp. depleted high diversity vaginal microbiota in early pregnancy had significantly shorter gestational length than <jats:italic>Lactobacillus<\/jats:italic> spp. dominated non-secretors (mean of 241.54\u2009days (<jats:sc>sd<\/jats:sc>=47.14) versus 266.21 (23.61); <jats:italic>P<\/jats:italic>-value=0.0251). Similar gestational length differences were observed between non-secretors with high vaginal diversity and secretors with <jats:italic>Lactobacillus<\/jats:italic> spp. dominance (mean of 262.52 days (SD=27.73); <jats:italic>p<\/jats:italic>-<jats:italic>value<\/jats:italic>=0.0439) or depletion (mean of 266.05 days (SD=20.81); <jats:italic>p<\/jats:italic>-<jats:italic>value<\/jats:italic>=0.0312). Our data highlight secretor status and blood-group antigen expression as being important mediators of vaginal microbiota\u2013host interactions in the context of preterm birth risk.<\/jats:p>","DOI":"10.1099\/mgen.0.001323","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T17:18:02Z","timestamp":1733332682000},"source":"Crossref","is-referenced-by-count":1,"title":["Secretor status is a modifier of vaginal microbiota-associated preterm birth risk"],"prefix":"10.1099","volume":"10","author":[{"given":"Samit","family":"Kundu","sequence":"first","affiliation":[{"name":"March of Dimes European Prematurity Research Centre, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gon\u00e7alo","family":"dos Santos Correia","sequence":"additional","affiliation":[{"name":"Institute for Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital Campus, London W12 0NN, UK"},{"name":"March 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