{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:40:23Z","timestamp":1776184823421,"version":"3.50.1"},"reference-count":19,"publisher":"Microbiology Society","issue":"9","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007224","name":"National Foundation for Science and Technology Development","doi-asserted-by":"crossref","award":["106.04-2020.08"],"award-info":[{"award-number":["106.04-2020.08"]}],"id":[{"id":"10.13039\/100007224","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,17]]},"abstract":"<jats:p>Multidrug-resistant <jats:italic>Acinetobacter baumannii<\/jats:italic> poses a significant threat to hospital environments worldwide, including Vietnam. In this study, we conducted whole-genome sequencing on 30 clinical <jats:italic>A. baumannii<\/jats:italic> isolates from Hanoi to explore their genomic diversity, antibiotic resistance determinants, virulence factors and mobile genetic elements. Phylogenetic analyses, utilizing both SNP-based and multilocus sequence typing-based approaches, revealed that the isolates clustered into various sequence types (STs). Among these, ST2 and ST571 emerged as the dominant high-risk clones. The ST2 isolates exhibited a wide range of resistance genes, such as <jats:italic>bla<\/jats:italic>\n                  <jats:sub>OXA-23<\/jats:sub>, <jats:italic>mph(E<\/jats:italic>), <jats:italic>msr(E<\/jats:italic>) and <jats:italic>armA<\/jats:italic>. Additionally, they contained mobile genetic elements, including plasmids and AbaR-type resistance islands, which promote horizontal gene transfer. Virulence gene analysis showed the presence of several key determinants like <jats:italic>ompA<\/jats:italic>, <jats:italic>adeFGH<\/jats:italic> and <jats:italic>bfmRS<\/jats:italic> and quorum sensing regulators <jats:italic>abaI<\/jats:italic> and <jats:italic>abaR<\/jats:italic>, underscoring the strains\u2019 potential for persistent colonization and infection. These findings highlight the marked genomic diversity and robust resistance profiles of Vietnamese <jats:italic>A. baumannii<\/jats:italic> isolates. The predominance of ST2 and ST571, corresponding to global clones GC2 and GC1, respectively, along with frequent co-occurrence of <jats:italic>bla<\/jats:italic>\n                  <jats:sub>OXA-23<\/jats:sub> and <jats:italic>armA<\/jats:italic>, suggests region-specific features distinct from those reported in other parts of Southeast Asia. This underscores the need for improved surveillance and targeted infection control strategies.<\/jats:p>","DOI":"10.1099\/mgen.0.001500","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T18:16:49Z","timestamp":1758133009000},"source":"Crossref","is-referenced-by-count":2,"title":["Dominance of high-risk clones ST2 and ST571 and the diversity of resistance islands in clinical Acinetobacter baumannii isolates from Hanoi, Vietnam"],"prefix":"10.1099","volume":"11","author":[{"given":"Minh Ngoc","family":"Nghiem","sequence":"first","affiliation":[{"name":"Institute of Biology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dung Phuong","family":"Bui","sequence":"additional","affiliation":[{"name":"VNU University of Science, 334 Nguyen Trai, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Van Thi Thu","family":"Ha","sequence":"additional","affiliation":[{"name":"Vietnam Medical Military University, 160 Phung Hung, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hop Thi","family":"Tran","sequence":"additional","affiliation":[{"name":"Institute of Biology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diem Thi","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Institute of Biology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6746-9573","authenticated-orcid":false,"given":"Thuy Thi Bich","family":"Vo","sequence":"additional","affiliation":[{"name":"Institute of Biology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do, Hanoi 100000, Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9030119"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad109"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.52389\/ydls.v0i0.2296"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10030373"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkae161"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11040520"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.02276-23"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00633-13"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000306"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2023.04.007"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.7324\/JABB.2024.146101"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001922"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.878912"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot4455"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02207-23"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.23750\/abm.v91i2.9176"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.148"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-15-1020"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05678-11"}],"container-title":["Microbial Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/mgen\/10.1099\/mgen.0.001500?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T18:16:50Z","timestamp":1758133010000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/mgen\/10.1099\/mgen.0.001500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,17]]},"references-count":19,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9,17]]}},"URL":"https:\/\/doi.org\/10.1099\/mgen.0.001500","relation":{},"ISSN":["2057-5858"],"issn-type":[{"value":"2057-5858","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,17]]}}}