{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:50:48Z","timestamp":1781106648771,"version":"3.54.1"},"reference-count":76,"publisher":"Microbiology Society","issue":"9","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sri Balaji Vidyapeeth","award":["SBV\/IRC\/SEED MONEY\/145\/2023 and SBV\/IRC\/SEED MONEY\/188\/2025"],"award-info":[{"award-number":["SBV\/IRC\/SEED MONEY\/145\/2023 and SBV\/IRC\/SEED MONEY\/188\/2025"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,9,22]]},"abstract":"<jats:p>\n                  <jats:italic>Parvimonas micra<\/jats:italic> is a Gram-positive, anaerobic bacterium commonly found in the oral cavity, skin and gastrointestinal tract. While typically a harmless organism, it can cause infections in individuals with weakened immune systems, leading to conditions like periodontitis and deep-tissue abscesses. This study focuses on the comparative genomic analysis of <jats:italic>P. micra<\/jats:italic> to explore its evolutionary relationships, antimicrobial resistance profiles and functional diversity by assessing phylogenetic analyses, resistance genes, virulence factors, mobile genetic elements, carbohydrate-active enzymes and pan-genome analysis. Comparative genomic analysis of 11 <jats:italic>P. micra<\/jats:italic> strains reveals significant functional variations among the strains, indicating notable interspecies diversity. Phylogenetic and comparative genome analysis revealed that strain JM503A is taxonomically distinct from the <jats:italic>P. micra<\/jats:italic> species, with genome similarity ranging from 54% to 61%. The 16S rRNA sequence similarity of strain JM503A is 98.28%, indicating a distinct phylogenetic position. The average nucleotide identity value ranging from 91.32% to 91.7% and digital DNA\u2013DNA hybridization values ranging from 43.00% to 44.00% of JM503A with other strains are below the cutoff values &lt;95%\u2009and &lt;70%, respectively, which confirms JM503A as a novel species. Based on its evolutionary relationships, strain JM503A is identified as a potential new species of <jats:italic>Parvimonas<\/jats:italic>, providing important evidence for its reclassification as a new species within the genus <jats:italic>Parvimonas<\/jats:italic>.<\/jats:p>","DOI":"10.1099\/mgen.0.001511","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T14:16:38Z","timestamp":1758550598000},"source":"Crossref","is-referenced-by-count":1,"title":["Comparative genome analysis of human pathogen Parvimonas micra revealed strain JM503A as potential novel species in the genus Parvimonas and high intra-species functional diversity"],"prefix":"10.1099","volume":"11","author":[{"given":"Roja","family":"Suresh","sequence":"first","affiliation":[{"name":"Mahatma Gandhi Medical Advanced Research Institute (MGMARI), Sri Balaji Vidyapeeth (Deemed to be University), Pondicherry 607402, 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