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Despite having among the highest rates reported worldwide, scarce genomic data are available on CRAB strains from the Middle East. Here, we report the global emergence of a novel International Clone (IC), designated IC12, based on the epidemiological, phenotypic and genome sequencing data (short reads and long reads) of a set of 60\n                    <jats:italic>A<\/jats:italic>\n                    .\n                    <jats:italic>baumannii<\/jats:italic>\n                    isolates belonging to multilocus sequence type 158 (Pasteur scheme). IC12, prevailing in the Middle East since 2007, has also been found in Europe, Asia and South America. Alleles OXA-65 and ADC-117, coded by the\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>OXA-51-like<\/jats:sub>\n                    and\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>ADC<\/jats:sub>\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    -intrinsic genes, respectively, were hallmarks shared by all the isolates. Plasmid pIC12-2 (80,000 bp), which carries a\n                    <jats:italic>repAci6<\/jats:italic>\n                    replication initiator (RP-T1) and a type IV conjugative transfer system, played a major role in the antimicrobial resistance profile of 54\/60 of the IC12 isolates. This resistance was mediated by three mobile genetic elements, namely Tn\n                    <jats:italic>2008<\/jats:italic>\n                    , MITE\n                    <jats:italic>Ab-IC12<\/jats:italic>\n                    and Tn\n                    <jats:italic>aphA6<\/jats:italic>\n                    . All four Peruvian IC12 isolates lacked pIC12-2 and carried a different set of plasmids. Two of the Peruvian isolates carried a chromosomal resistance island of 79,396\u2009bp long (designated IC12-RI) marked by the occurrence of\n                    <jats:italic>tet<\/jats:italic>\n                    (X3). The global spread of IC12 is worrying and calls for further studies on the virulence features and clinical impact of this clone.\n                  <\/jats:p>","DOI":"10.1099\/mgen.0.001572","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T18:17:13Z","timestamp":1764353833000},"source":"Crossref","is-referenced-by-count":8,"title":["Global emergence of Acinetobacter baumannii International Clone 12 predominantly found in the Middle East"],"prefix":"10.1099","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8867-658X","authenticated-orcid":false,"given":"Nabil","family":"Karah","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Faille","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Infectious Diseases, Universit\u00e9 de Sherbrooke, Sherbrooke, Qu\u00e9bec, 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