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However, there is a paucity of genomic data on these important pathogens. Of the 11 common\n                    <jats:italic>Eimeria<\/jats:italic>\n                    species in rabbits, only\n                    <jats:italic>Eimeria stiedae<\/jats:italic>\n                    invades biliary epithelial cells rather than the intestine, and the determinants of coccidian tissue tropism remain unclear. In this study, we sequenced the genomes of five common rabbit\n                    <jats:italic>Eimeria<\/jats:italic>\n                    species, including\n                    <jats:italic>E. stiedae<\/jats:italic>\n                    ,\n                    <jats:italic>Eimeria flavescens<\/jats:italic>\n                    ,\n                    <jats:italic>Eimeria intestinalis<\/jats:italic>\n                    ,\n                    <jats:italic>Eimeria magna<\/jats:italic>\n                    and\n                    <jats:italic>Eimeria media<\/jats:italic>\n                    . Comparative genomic analysis reveals that the genome of\n                    <jats:italic>E. stiedae<\/jats:italic>\n                    appears more compact than the genomes of intestinal\n                    <jats:italic>Eimeria<\/jats:italic>\n                    species. It shows reductions in the numbers of rhoptry proteins, dense granule proteins, microneme adhesive repeats and TA4 surface antigens, suggesting that surface and invasion-associated proteins may be involved in the tissue tropism of\n                    <jats:italic>Eimeria<\/jats:italic>\n                    spp. In addition,\n                    <jats:italic>E. stiedae<\/jats:italic>\n                    -specific motifs are identified in a cluster of hypothetical surface antigens. These data provide not only new insights into the biological characteristics of coccidia but also valuable resources for functional research and drug and vaccine development.\n                  <\/jats:p>","DOI":"10.1099\/mgen.0.001576","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T18:16:24Z","timestamp":1764267384000},"source":"Crossref","is-referenced-by-count":0,"title":["Comparative genomic analysis of five Eimeria spp. in rabbits provides insights into coccidian tissue tropism"],"prefix":"10.1099","volume":"11","author":[{"given":"Tianyi","family":"Hou","sequence":"first","affiliation":[{"name":"State Key Laboratory for Animal Disease Control and Prevention, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongle","family":"Su","sequence":"additional","affiliation":[{"name":"State Key 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