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Here, we describe the isolation of\n                    <jats:italic>O. hominis<\/jats:italic>\n                    from samples collected from a South African birth cohort, creating the first archive of cultured strains of the species from Africa. Sequenced genomes from this archive reveal that South African\n                    <jats:italic>O. hominis<\/jats:italic>\n                    is more similar to Australian strains than those from Southeast Asia and that it may share genes with other members of the microbiome that are relevant for virulence, colonization and antibiotic resistance. Leveraging existing microbiome data from the cohort,\n                    <jats:italic>O. hominis<\/jats:italic>\n                    was found to be closely associated with bacterial co-colonizers that are rare in non-carrier individuals, including\n                    <jats:italic>Suttonella<\/jats:italic>\n                    ,\n                    <jats:italic>Rappaport<\/jats:italic>\n                    ,\n                    <jats:italic>Helcococcus<\/jats:italic>\n                    ,\n                    <jats:italic>Lwoffella<\/jats:italic>\n                    ,\n                    <jats:italic>Moraxella<\/jats:italic>\n                    and\n                    <jats:italic>Gracilibacteria<\/jats:italic>\n                    . Their collective acquisition has a significant impact on the diversity of nasopharyngeal communities that contain\n                    <jats:italic>O. hominis<\/jats:italic>\n                    . Individuals who have not yet acquired\n                    <jats:italic>O. hominis<\/jats:italic>\n                    have a higher abundance of\n                    <jats:italic>Lwoffella lincolnii<\/jats:italic>\n                    than individuals who never acquire\n                    <jats:italic>O. hominis<\/jats:italic>\n                    , suggesting that this could be a precursor state for successful colonization.\n                  <\/jats:p>","DOI":"10.1099\/mgen.0.001635","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T15:16:54Z","timestamp":1779117414000},"source":"Crossref","is-referenced-by-count":0,"title":["Characterization of Ornithobacterium hominis colonization dynamics and interaction with the nasopharyngeal microbiome in a South African birth cohort"],"prefix":"10.1099","volume":"12","author":[{"given":"Celine C.","family":"De Allende","sequence":"first","affiliation":[{"name":"Department of Molecular and Cell Biology & 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