{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:23:22Z","timestamp":1793395402006,"version":"4.5.0"},"reference-count":49,"publisher":"Microbiology Society","issue":"2","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Technology Sydney Research Office","award":["2700243"],"award-info":[{"award-number":["2700243"]}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"crossref","award":["FT230100400"],"award-info":[{"award-number":["FT230100400"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,13]]},"abstract":"<jats:p>\n                    <jats:italic>Acinetobacter variabilis<\/jats:italic>\n                    is an opportunistic pathogen found in both clinical and environmental settings with the potential to harbour and disseminate clinically significant antibiotic resistance genes. Here, we sequenced the complete genome of NGH-QLD-N1, an\n                    <jats:italic>A. variabilis<\/jats:italic>\n                    isolate recovered from a blood sample of a patient at Nambour General Hospital located on the Sunshine Coast region of Queensland, Australia. The assembly was used as a reference to assess the diversity in available\n                    <jats:italic>A. variabilis<\/jats:italic>\n                    genome sequences and investigate the genomic context of surface polysaccharide biosynthesis genes and antibiotic resistance determinants in relation to the priority pathogen,\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    . Phylogenetic analysis revealed substantial diversity in the species, with a distinct NGH-QLD-N1 subclade containing multiple strains with important resistance determinants. We identified a novel transposon related to the Tn\n                    <jats:italic>6022<\/jats:italic>\n                    family, designated Tn\n                    <jats:italic>6929<\/jats:italic>\n                    , that interrupted\n                    <jats:italic>comM<\/jats:italic>\n                    and identified multiple structural variants in\n                    <jats:italic>A. variabilis<\/jats:italic>\n                    genomes. Notably, some variants carried\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM<\/jats:sub>\n                    and\n                    <jats:italic>aphA6<\/jats:italic>\n                    in ISAba14-bounded regions, suggesting acquisition from diverse bacterial hosts. We also identified several integrative conjugative elements (ICEs) variants integrated into the chromosomal\n                    <jats:italic>thyA<\/jats:italic>\n                    gene, which differed in backbone structure and resistance gene content from our previously described\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    ICE. The capsule and outer core loci for surface carbohydrate structures also had similar arrangements to those found in\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    . This study provides a new understanding of the diversity of mobile genetic elements and ICEs carrying resistance genes, and surface polysaccharides associated with virulence, across the\n                    <jats:italic>Acinetobacter<\/jats:italic>\n                    genus.\n                  <\/jats:p>","DOI":"10.1099\/mgen.0.001643","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T16:15:57Z","timestamp":1770999357000},"source":"Crossref","is-referenced-by-count":1,"title":["Acinetobacter variabilis represents a diverse species with novel regions associated with antibiotic resistance and surface polysaccharides"],"prefix":"10.1099","volume":"12","author":[{"given":"Lucy L.","family":"Patterson","sequence":"first","affiliation":[{"name":"Australian Institute for Microbiology and Infection, University of Technology Sydney, Ultimo, NSW, 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