{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T17:08:25Z","timestamp":1778605705671,"version":"3.51.4"},"reference-count":49,"publisher":"Microbiology Society","issue":"5","license":[{"start":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:00:00Z","timestamp":1778544000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100023961","name":"Centro de Investigaci\u00f3n Biotecnol\u00f3gica en Red de Enfermedades Infecciosas","doi-asserted-by":"crossref","award":["CB21\/13\/00054"],"award-info":[{"award-number":["CB21\/13\/00054"]}],"id":[{"id":"10.13039\/501100023961","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"crossref","award":["PI21\/00132"],"award-info":[{"award-number":["PI21\/00132"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,12]]},"abstract":"<jats:p>\n                    <jats:italic>Neisseria meningitidis<\/jats:italic>\n                    clonal complex 11 (cc11) is a hyperinvasive lineage associated with global dissemination and outbreaks, including the \u2018South American\/UK\u2019 sublineage. In Spain, cc11 serogroup W cases have increased in recent years; however, the evolutionary dynamics of circulating variants remain insufficiently characterized. This study aimed to assess the clonal diversity, temporal evolution and antimicrobial resistance profiles of cc11 isolates recovered in Spain between 2011 and 2025. A total of 1,226 isolates (406 invasive and 820 non-invasive) were collected across 8 Spanish regions, from which cc11 isolates were selected for analysis. Whole-genome sequencing (WGS) was used to perform core-genome multilocus sequence typing and SNP-based Bayesian phylogenetics to characterize population structure. Antimicrobial susceptibility was assessed using gradient diffusion, and genetic determinants of resistance were identified by WGS. We identified 179 cc11 isolates, mostly belonging to genogroup W (73.7%) and lineage 11.1 (85.5%). The \u2018South American\/UK\u2019 sublineage was the main sublineage and displayed extensive diversification. A previously undescribed variant, designated the \u20182020 strain\u2019, emerged with an estimated most recent common ancestor in 2017 and accounted for 77.2% of \u2018South American\/UK\u2019 sublineage isolates recovered between 2023 and 2025. This variant was mainly identified in respiratory samples from men who have sex with men but was also associated with invasive meningococcal disease in other population groups. The \u20182020 strain\u2019 exhibited resistance to penicillin and azithromycin, likely driven by penicillin-binding protein 2 and MtrCDE alterations. The emergence of this antimicrobial-resistant variant highlights the adaptive capacity of cc11 and the importance of genomic surveillance to monitor its evolution and public health relevance.\n                  <\/jats:p>","DOI":"10.1099\/mgen.0.001703","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T16:15:28Z","timestamp":1778602528000},"source":"Crossref","is-referenced-by-count":0,"title":["Genomic and evolutionary insights into a novel Neisseria meningitidis genogroup W clonal complex 11 variant with dual resistance to penicillin and azithromycin in Spain"],"prefix":"10.1099","volume":"12","author":[{"given":"Josep","family":"Roca-Grande","sequence":"first","affiliation":[{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Departament de Gen\u00e8tica i Microbiologia, Universitat Aut\u00f2noma de Barcelona (UAB), Bellaterra, Spain"},{"name":"Microbiology Research Group, Institut de Recerca Vall d\u2019Hebron (VHIR), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Moreno-Mingorance","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Microbiology Research Group, Institut de Recerca Vall d\u2019Hebron (VHIR), Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"\u00c1lvarez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Infectious Diseases, STI\/HIV Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maider","family":"Arando","sequence":"additional","affiliation":[{"name":"Infectious Diseases, STI\/HIV Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Bell\u00e9s-Bell\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Hospital Universitari Arnau de Vilanova, Institut de Recerca Biom\u00e8dica de Lleida \u2013 Fundaci\u00f3 Dr. Pifarr\u00e9, IRBLleida, Av. Alcalde Rovira Roure, 80, 25198, Lleida, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Calvo-Montes","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Hospital Universitario Marqu\u00e9s de Valdecilla-IDIVAL, Santander, Spain"},{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi","family":"C\u00e0mara","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain"},{"name":"Department of Clinical Microbiology, Hospital Universitari de Bellvitge, IDIBELL-UB, L\u2019Hospitalet de Llobregat, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia","family":"Cercenado","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology and Infectious Disease, Hospital 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