{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:05:58Z","timestamp":1783958758597,"version":"3.55.0"},"reference-count":46,"publisher":"Microbiology Society","issue":"7","license":[{"start":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T00:00:00Z","timestamp":1783900800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union - NextGenerationEU Program MUR PNRR","award":["PE00000007"],"award-info":[{"award-number":["PE00000007"]}]},{"name":"European Union - NextGenerationEU Program MUR PNRR","award":["PE00000007"],"award-info":[{"award-number":["PE00000007"]}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"crossref","award":["773830"],"award-info":[{"award-number":["773830"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,13]]},"abstract":"<jats:p>\n                    Multidrug-resistant\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    subsp.\n                    <jats:italic>enterica<\/jats:italic>\n                    serovar Infantis clone, harbouring the pESI megaplasmid, first described in Israel in 2014, is consistently reported in poultry and humans worldwide. This study aimed to investigate the genomic epidemiology of\n                    <jats:italic>S<\/jats:italic>\n                    . Infantis collected by nine European Public Health Institutions from samples of different origins (human, food and animal sources) and understand the evolutionary dynamics of pESI-like in Europe. The resolved pESI-like sequences have also been compared with complete publicly available pESI-like sequences from other countries, in a One Health context. The circulation of a\n                    <jats:italic>S<\/jats:italic>\n                    . Infantis clone in Europe carrying the mosaic megaplasmid pESI-like has been associated with resistance to sulphonamides (\n                    <jats:italic>sul<\/jats:italic>\n                    )\n                    <jats:italic>,<\/jats:italic>\n                    tetracycline (\n                    <jats:italic>tet<\/jats:italic>\n                    )\n                    <jats:italic>,<\/jats:italic>\n                    streptomycin and spectinomycin (\n                    <jats:italic>aadA1<\/jats:italic>\n                    ). In recent years,\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>CTX-M-1<\/jats:sub>\n                    -positive pESI-like plasmids have been increasingly detected in the extended-spectrum beta-lactamase-producing\n                    <jats:italic>S<\/jats:italic>\n                    . Infantis clone. Using a combined short- and long-read sequencing approach, two main types of pESI variants have been identified, differing in the accessory gene content, including the\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>CTX-M<\/jats:sub>\n                    variant, indicating a certain stability of pESI variants detected in different geographical regions and sources over time (2011\u20132021). Moreover, the differences were related to the acquisition of resistance, virulence or fitness-enhancing genes that would potentially benefit the\n                    <jats:italic>Salmonella<\/jats:italic>\n                    host.\n                  <\/jats:p>","DOI":"10.1099\/mgen.0.001787","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T15:15:36Z","timestamp":1783955736000},"source":"Crossref","is-referenced-by-count":0,"title":["Evolutionary dynamics of the multidrug-resistant Salmonella Infantis harbouring the pESI megaplasmid across Europe"],"prefix":"10.1099","volume":"12","author":[{"given":"Patricia","family":"Alba","sequence":"first","affiliation":[{"name":"Department of General Diagnostics, National Reference Laboratory for Antimicrobial Resistance, Istituto Zooprofilattico Sperimentale del Lazio e della Toscana \u201cM. Aleandri\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena Lavinia","family":"Diaconu","sequence":"additional","affiliation":[{"name":"Department of General Diagnostics, National Reference Laboratory for Antimicrobial Resistance, Istituto Zooprofilattico Sperimentale del Lazio e della Toscana \u201cM. Aleandri\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Carfora","sequence":"additional","affiliation":[{"name":"Department of General Diagnostics, National Reference Laboratory for Antimicrobial Resistance, Istituto Zooprofilattico Sperimentale del Lazio e della Toscana \u201cM. Aleandri\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Battisti","sequence":"additional","affiliation":[{"name":"Department of General Diagnostics, National Reference Laboratory for Antimicrobial Resistance, Istituto Zooprofilattico Sperimentale del Lazio e della Toscana \u201cM. Aleandri\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of General Diagnostics, National Reference Laboratory for Antimicrobial Resistance, Istituto Zooprofilattico Sperimentale del Lazio e della Toscana \u201cM. Aleandri\u201d, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter-Jan","family":"Ceyssens","sequence":"additional","affiliation":[{"name":"Sciensano, Department of Human Infectious Diseases, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Graells-Garcia","sequence":"additional","affiliation":[{"name":"Sciensano, Department of Human Infectious Diseases, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannice Schau","family":"Sletteme\u00e5s","sequence":"additional","affiliation":[{"name":"Norwegian Veterinary Institute, Department of Animal Health, Welfare and Food Safety, \u00c5s, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Zaj\u0105c","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Bacterial Animal Diseases, National Veterinary Research Institute (PIWET), Al. 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