{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T15:12:13Z","timestamp":1751555533158},"reference-count":57,"publisher":"Microbiology Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,8,1]]},"DOI":"10.1099\/mic.0.000318","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T06:12:29Z","timestamp":1464934349000},"page":"1407-1421","source":"Crossref","is-referenced-by-count":5,"title":["Decrease in antithrombin III and prothrombin serum levels contribute to coagulation disorders during leptospirosis"],"prefix":"10.1099","volume":"162","author":[{"given":"Luis G. V.","family":"Fernandes","sequence":"first","affiliation":[{"name":"Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, 1500, 05503-900, Sao Paulo, SP, Brazil"},{"name":"Programa de Pos-Graduacao Interunidades em Biotecnologia, Instituto de Ci\u00eancias Biom\u00e9dicas, USP, Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio F. S.","family":"Filho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Zoonoses Bacterianas do VPS, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, USP, Avenida Prof. Dr Orlando Marques de Paiva, 87, 05508-270, Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisele O.","family":"Souza","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Zoonoses Bacterianas do VPS, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, USP, Avenida Prof. Dr Orlando Marques de Paiva, 87, 05508-270, Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvio A.","family":"Vasconcellos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Zoonoses Bacterianas do VPS, Faculdade de Medicina Veterin\u00e1ria e Zootecnia, USP, Avenida Prof. Dr Orlando Marques de Paiva, 87, 05508-270, Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliete C.","family":"Romero","sequence":"additional","affiliation":[{"name":"Centro de Bacteriologia, Instituto Adolfo Lutz, Avenida Dr Arnaldo, 355, CEP 01246-902,  Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L. T. O.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Centro de Biotecnologia, Instituto Butantan, Avenida Vital Brazil, 1500, 05503-900, Sao Paulo, SP, Brazil"},{"name":"Programa de Pos-Graduacao Interunidades em Biotecnologia, Instituto de Ci\u00eancias Biom\u00e9dicas, USP, Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000186267.66402.24"},{"key":"R3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1182\/blood.V74.1.165.165","article-title":"Tumor necrosis factor infusions have a procoagulant effect on the hemostatic mechanism of humans","volume":"74","author":"Bauer","year":"1989","journal-title":"Blood"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(03)00830-2"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.03.050"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1086\/524664"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.1996.tb08159.x"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31819267fb"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86821995000300002"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.4.1677-1683.2002"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.623"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.53.070184.001211"},{"key":"R12","first-page":"347","article-title":"Impact of clinical and laboratory findings on prognosis in leptospirosis","volume":"134","author":"Esen","year":"2004","journal-title":"Swiss Med Wkly"},{"key":"R13","first-page":"254","article-title":"Inflammation, sepsis, and coagulation","volume":"84","author":"Esmon","year":"1999","journal-title":"Haematologica"},{"key":"R1","volume-title":"Leptospira and Leptospirosis","author":"Faine","year":"1999"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftv001"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00474-12"},{"key":"R17","first-page":"174","article-title":"The pathogenesis of leptospirosis I. Hemorrhages in experimental leptospirosis in guinea pigs","volume":"41","author":"Higgins","year":"1977","journal-title":"Can J Comp Med"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)80012-9"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.2.296-326.2001"},{"key":"R25","first-page":"10-12","article-title":"The coagulant response in sepsis and inflammation","volume":"30","author":"Levi","year":"2010","journal-title":"Hamostaseologie"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12221"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1092876"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1023\/B:THRO.0000014592.27892.11"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1145256"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908193410807"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.1997.570614.x"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.418699"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000154"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1016\/0305-0491(96)00114-9"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1086\/313501"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.05727-11"},{"key":"R32","first-page":"70","article-title":"In vitro effect of Leptospira icterohaemorrhagiae on human mononuclear leukocytes procoagulant activity: comparison of virulent with nonvirulent strain","volume":"47","author":"Miragliotta","year":"1983","journal-title":"Can J Comp Med"},{"key":"R33","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4269\/ajtmh.1997.56.181","article-title":"Lung lesions in human leptospirosis: microscopic, immunohistochemical, and ultrastructural features related to thrombocytopenia","volume":"56","author":"Nicodemo","year":"1997","journal-title":"Am J Trop Med Hyg"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002396"},{"key":"R57","doi-asserted-by":"publisher","DOI":"10.1055\/s-2001-18866"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(00)01280-6"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002457"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1086\/427110"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.5.1177"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122762"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e318157ee55"},{"key":"R41","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0035-9203(70)90087-8","article-title":"Leptospirosis. 3. Maintenance, isolation and demonstration of leptospires","volume":"64","author":"Turner","year":"1970","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199006073222302"},{"key":"R55","doi-asserted-by":"publisher","DOI":"10.1086\/314829"},{"key":"R58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0004713"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00353-09"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00397-15"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2009.02434.x"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2006.01792.x"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042266"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-3233(05)70008-5"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1038\/86354"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901213400307"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000119"},{"key":"R51","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2334-6-19","article-title":"Thrombocytopenia in the experimental leptospirosis of guinea pig is not related to disseminated intravascular coagulation","volume":"6","author":"Yang","year":"2006b","journal-title":"BMC Infect Dis"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2008.41.2.119"},{"key":"R53","first-page":"520","article-title":"[Research on the expression of hemolysin genes of Leptospira in vivo by GeneChip]","volume":"43","author":"Zhao","year":"2012","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"}],"container-title":["Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/mic.0.000318?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T09:11:49Z","timestamp":1575623509000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/mic.0.000318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,1]]},"references-count":57,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8,1]]}},"URL":"https:\/\/doi.org\/10.1099\/mic.0.000318","relation":{},"ISSN":["1350-0872","1465-2080"],"issn-type":[{"value":"1350-0872","type":"print"},{"value":"1465-2080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,1]]}}}