{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:25:03Z","timestamp":1761153903187,"version":"3.37.3"},"reference-count":104,"publisher":"Microbiology Society","issue":"5","funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura \u010cesk\u00e9 Republiky","doi-asserted-by":"crossref","award":["17-21244S"],"award-info":[{"award-number":["17-21244S"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,1]]},"abstract":"<jats:p>Lyme borreliosis is a vector-borne infection caused by bacteria under the<jats:italic><jats:named-content content-type=\"species\"><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.7818\" xlink:type=\"simple\">Borrelia burgdorferi<\/jats:ext-link><\/jats:named-content><\/jats:italic>sensu lato complex, both in Europe and North America. Differential gene expression at different times throughout its infectious cycle allows the spirochete to survive very diverse environments within different mammalian hosts as well as the tick vector. To date, the vast majority of data about spirochetal proteins and their functions are from genetic studies carried out on North American strains of a single species, i.e.<jats:italic>B. burgdorferi sensu stricto<\/jats:italic>. The whole-genome sequences recently obtained for several European species\/strains make it feasible to adapt and use genetic techniques to study inherent differences between them. This review highlights the crucial need to undertake independent studies of genospecies within Europe, given their varying genetic content and pathogenic potential, and differences in clinical manifestation.<\/jats:p>","DOI":"10.1099\/mic.0.000899","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T17:06:58Z","timestamp":1583255218000},"page":"428-435","source":"Crossref","is-referenced-by-count":10,"title":["The need to unravel the twisted nature of the Borrelia burgdorferi sensu lato complex across Europe"],"prefix":"10.1099","volume":"166","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1671-6252","authenticated-orcid":false,"given":"Martin","family":"Strnad","sequence":"first","affiliation":[{"name":"Faculty of Science, University of South Bohemia, Branisovska 31, 37005, Ceske Budejovice, Czech Republic"},{"name":"Biology Centre, Institute of Parasitology, Czech Academy of Sciences, Branisovska 31, 37005, Ceske Budejovice, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan O.M.","family":"Rego","sequence":"additional","affiliation":[{"name":"Biology Centre, Institute of Parasitology, Czech Academy of Sciences, Branisovska 31, 37005, Ceske Budejovice, Czech Republic"},{"name":"Faculty of Science, University of South Bohemia, Branisovska 31, 37005, Ceske Budejovice, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","first-page":"113","article-title":"Genetic manipulation of Borrelia spp","volume":"415","author":"Drecktrah","year":"2018","journal-title":"Curr Top Microbiol Immunol"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1038\/37551"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-15-233"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-018-4597-x"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.3389\/fevo.2019.00401"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60103-7"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.001445"},{"key":"R8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1086\/514551","article-title":"Clinical findings for patients with Lyme borreliosis caused by Borrelia burgdorferi sensu lato with genotypic and phenotypic similarities to strain 25015","volume":"25","author":"Strle","year":"1997","journal-title":"Clin Infect Dis Off Publ Infect Dis Soc Am"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.000897"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.3.1316-1318.2004"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.3201\/eid1009.030439"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-017-1032-1"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2007.12.013"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00609-17"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03175.x"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.02.010"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fux047"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1086\/506936"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw417"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.1997.tb00259.x"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2015.08.017"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.278331"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-019-3468-x"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.2807\/esw.11.25.02977-en"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003796"},{"year":"2011","key":"R26","article-title":"United K eng, Halperin JJ 178318 (ed). 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