{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:55:25Z","timestamp":1790693725962,"version":"4.1.0"},"reference-count":10,"publisher":"Microbiology Society","issue":"3","funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"crossref","award":["ANR-10-LABX-62-IBEID"],"award-info":[{"award-number":["ANR-10-LABX-62-IBEID"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"crossref","award":["31003A_175557 and 310030_200706"],"award-info":[{"award-number":["31003A_175557 and 310030_200706"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"crossref","award":["EQU201903007847"],"award-info":[{"award-number":["EQU201903007847"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p>\n                  <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.10820\" xlink:type=\"simple\">Legionella pneumophila<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> is an environmental bacterium that parasitizes aquatic protozoa and uses the same processes to infect humans. The facultative intracellular pathogen causes a life-threatening pneumonia with possible systemic complications. The co-evolution with protozoa is reflected in an armoury of bacterial effectors, and many of these type IV-secreted proteins have likely been acquired by interdomain horizontal gene transfer (HGT) from hosts. The unique features of <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.10820\" xlink:type=\"simple\">L. pneumophila<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> are the largest bacterial effector repertoire known to date, subversion of virtually all eukaryotic signalling pathways and acquisition of eukaryotic enzyme activities used to manipulate the host cell to the pathogen\u2019s advantage.<\/jats:p>","DOI":"10.1099\/mic.0.001142","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T17:16:42Z","timestamp":1646155002000},"source":"Crossref","is-referenced-by-count":27,"title":["Microbe Profile: Legionella pneumophila - a copycat eukaryote"],"prefix":"10.1099","volume":"168","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5462-9301","authenticated-orcid":false,"given":"Hubert","family":"Hilbi","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, University of Z\u00fcrich, Gloriastrasse 30, 8006 Z\u00fcrich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3477-9190","authenticated-orcid":false,"given":"Carmen","family":"Buchrieser","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Universit\u00e9 de Paris, CNRS UMR 6047 Unit\u00e9 Biologie des Bact\u00e9ries Intracellulaires, 75015 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1447"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099776"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197712012972202"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1808016116"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0663-7"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2015.11.002"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.67"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001216"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020046"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2021.09.001"}],"container-title":["Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/mic.0.001142?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T15:21:04Z","timestamp":1655824864000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/mic.0.001142"}},"subtitle":["This article is part of the Microbe Profiles collection."],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,3,1]]}},"URL":"https:\/\/doi.org\/10.1099\/mic.0.001142","relation":{},"ISSN":["1350-0872","1465-2080"],"issn-type":[{"value":"1350-0872","type":"print"},{"value":"1465-2080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,1]]}}}