{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:59:32Z","timestamp":1789174772371,"version":"build-2803163510"},"reference-count":10,"publisher":"Microbiology Society","issue":"9","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,30]]},"abstract":"\n \n \n Wigglesworthia glossinidia<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> is an obligate, maternally transmitted endosymbiont of tsetse flies. The ancient association between these two organisms accounts for many of their unique physiological adaptations. Similar to other obligate mutualists, \n \n Wigglesworthia<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>\u2019s genome is dramatically reduced in size, yet it has retained the capacity to produce many B-vitamins that are found at inadequate quantities in the fly\u2019s vertebrate blood-specific diet. These \n \n Wigglesworthia<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>-derived B-vitamins play essential nutritional roles to maintain tsetse\u2019s physiological homeostasis as well as that of other members of the fly\u2019s microbiota. In addition to its nutritional role, \n \n Wigglesworthia<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> contributes towards the development of tsetse\u2019s immune system during the larval period. Tsetse produce amidases that degrade symbiotic peptidoglycans and prevent activation of antimicrobial responses that can damage \n \n Wigglesworthia<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic>. These amidases in turn exhibit antiparasitic activity and decrease tsetse\u2019s ability to be colonized with parasitic trypanosomes, which reduce host fitness. Thus, the \n \n Wigglesworthia<\/jats:ext-link>\n <\/jats:named-content>\n <\/jats:italic> symbiosis represents a fine-tuned association in which both partners actively contribute towards achieving optimal fitness outcomes.<\/jats:p>","DOI":"10.1099\/mic.0.001242","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T16:18:06Z","timestamp":1663777086000},"source":"Crossref","is-referenced-by-count":9,"title":["Microbe Profile: Wigglesworthia glossinidia: the tsetse fly\u2019s significant other"],"prefix":"10.1099","volume":"168","author":[{"given":"Brian L.","family":"Weiss","sequence":"first","affiliation":[{"name":"Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita V. M.","family":"Rio","sequence":"additional","affiliation":[{"name":"Department of Biology, Eberly College of Arts and Sciences, West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9941-143X","authenticated-orcid":false,"given":"Serap","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-45-4-848"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1038\/ng986"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00240-11"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1007\/pl00006444"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2016.05.002"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00018-19"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003318"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.19535"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1116431109"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2017.0360"}],"container-title":["Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/mic.0.001242?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T18:26:22Z","timestamp":1702578382000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/mic.0.001242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,30]]},"references-count":10,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9,30]]}},"URL":"https:\/\/doi.org\/10.1099\/mic.0.001242","relation":{},"ISSN":["1350-0872","1465-2080"],"issn-type":[{"value":"1350-0872","type":"print"},{"value":"1465-2080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,30]]}}}