{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:35:58Z","timestamp":1790746558110,"version":"4.1.0"},"reference-count":87,"publisher":"Microbiology Society","issue":"1","license":[{"start":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T00:00:00Z","timestamp":1704672000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,8]]},"abstract":"<jats:p>One of the mechanisms employed by the opportunistic pathogen <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.1627\" xlink:type=\"simple\">Burkholderia cenocepacia<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> to acquire the essential element iron is the production and release of two ferric iron chelating compounds (siderophores), ornibactin and pyochelin. Here we show that <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.1627\" xlink:type=\"simple\">B. cenocepacia<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> is also able to take advantage of a range of siderophores produced by other bacteria and fungi (\u2018xenosiderophores\u2019) that chelate iron exclusively by means of hydroxamate groups. These include the tris-hydroxamate siderophores ferrioxamine B, ferrichrome, ferricrocin and triacetylfusarinine C, the bis-hydroxamates alcaligin and rhodotorulic acid, and the monohydroxamate siderophore cepabactin. We also show that of the 24 TonB-dependent transporters encoded by the <jats:italic>\n                     <jats:named-content content-type=\"species\">\n                        <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/doi.org\/10.1601\/nm.1627\" xlink:type=\"simple\">B. cenocepacia<\/jats:ext-link>\n                     <\/jats:named-content>\n                  <\/jats:italic> genome, two (FhuA and FeuA) are involved in the uptake of hydroxamate xenosiderophores, with FhuA serving as the exclusive transporter of iron-loaded ferrioxamine B, triacetylfusarinine C, alcaligin and rhodotorulic acid, while both FhuA and FeuA are able to translocate ferrichrome-type siderophores across the outer membrane. Finally, we identified FhuB, a putative cytoplasmic membrane-anchored ferric-siderophore reductase, as being obligatory for utilization of all of the tested bis- and tris-hydroxamate xenosiderophores apart from alcaligin.<\/jats:p>","DOI":"10.1099\/mic.0.001425","type":"journal-article","created":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T14:17:02Z","timestamp":1704723422000},"source":"Crossref","is-referenced-by-count":10,"title":["Identification of a system for hydroxamate xenosiderophore-mediated iron transport in Burkholderia cenocepacia"],"prefix":"10.1099","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0668-0273","authenticated-orcid":false,"given":"Syakira Mohammed","family":"Hussein","sequence":"first","affiliation":[{"name":"Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Medical School, Beech Hill Road, Sheffield S10 2RX, 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