{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:49:44Z","timestamp":1787010584111,"version":"build-2736575974"},"reference-count":102,"publisher":"Microbiology Society","issue":"11","license":[{"start":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T00:00:00Z","timestamp":1732752000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"crossref","award":["1R01DE027669-01"],"award-info":[{"award-number":["1R01DE027669-01"]}],"id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,28]]},"abstract":"<jats:p>\n                    Inorganic polyphosphates (polyPs) are energy-storing biopolymers synthesized by all three domains of life. PolyP accumulation has been well studied with respect to its role in stress response, but its role in dental disease has received less attention. Dental decay can be promoted by changes in pH as well as the chemical activity of ions such as phosphate in oral fluids at the enamel interface. Previous work has shown that the drawdown of phosphate from biofilm fluids can alter the saturation state of oral fluids to thermodynamically favour mineral dissolution. The members of the Lactobacillaceae are known to accumulate polyP and play a role in early-stage and late-stage dental caries. In this study, we examined the effects of potential metabolic inhibitors on polyP accumulation in\n                    <jats:italic>Lacticaseibacillus rhamnosus<\/jats:italic>\n                    . We observed that two inhibitors of the enzyme responsible for polyP synthesis, gallein and fluoride, inhibited polyP accumulation in a balanced medium. However, fluoride and gallein treatments amended with either glucose or lactate were found to enhance polyP accumulation. These results illustrate the potential complexity of polyP metabolism in the oral environment.\n                  <\/jats:p>","DOI":"10.1099\/mic.0.001519","type":"journal-article","created":{"date-parts":[[2024,11,28]],"date-time":"2024-11-28T11:17:28Z","timestamp":1732792648000},"source":"Crossref","is-referenced-by-count":4,"title":["Fluoride and gallein regulate polyphosphate accumulation in dental caries-associated Lacticaseibacillus"],"prefix":"10.1099","volume":"170","author":[{"given":"Subhrangshu","family":"Mandal","sequence":"first","affiliation":[{"name":"Department of Botany, Visva Bharati University, Bolpur, West Bengal, India"},{"name":"Department of Earth & Environmental Sciences, University of Minnesota \u2013 Twin Cities, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly E.","family":"Flood","sequence":"additional","affiliation":[{"name":"Department of Earth & Environmental Sciences, University of Minnesota \u2013 Twin 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