{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:09:23Z","timestamp":1790662163334,"version":"4.1.0"},"reference-count":42,"publisher":"Microbiology Society","issue":"3","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"crossref","award":["UKRI1911"],"award-info":[{"award-number":["UKRI1911"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Department of Justice, Ireland.","award":["DOJProject209825"],"award-info":[{"award-number":["DOJProject209825"]}]},{"DOI":"10.13039\/501100000691","name":"Academy of Medical Sciences","doi-asserted-by":"crossref","award":["SBF006\u22161040"],"award-info":[{"award-number":["SBF006\u22161040"]}],"id":[{"id":"10.13039\/501100000691","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Medical Research Council","award":["MR\/Y001354\/1"],"award-info":[{"award-number":["MR\/Y001354\/1"]}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"crossref","award":["BB\/V007823\/1"],"award-info":[{"award-number":["BB\/V007823\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,23]]},"abstract":"<jats:p>\n                    The antibiotic resistance crisis has created an urgent need for the development of novel therapeutic strategies to tackle recalcitrant infections. In this study, we identified Tormentil [\n                    <jats:italic>Potentilla erecta<\/jats:italic>\n                    (L.) Raeusch.], a plant that has been used in traditional medicine for centuries, as being capable of effectively inhibiting the growth of carbapenem-resistant\n                    <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    . We identified agrimoniin and ellagic acid as two bioactive components with antibacterial activity present within Tormentil extracts. Combinatorial RNA-seq analysis revealed that these compounds were able to inhibit the growth of\n                    <jats:italic>A. baumannii<\/jats:italic>\n                    by disrupting intracellular iron homeostasis, an effect that could be reversed through exogenous iron supplementation. We also demonstrated that Tormentil could potentiate the activity of the last-resort antibiotic, colistin. Overall, these findings valorize the centuries-old traditional use of Tormentil to treat infection and highlight how its bioactive constituents could be exploited to prolong the lifespan of our last line of antibiotic defence, colistin.\n                  <\/jats:p>","DOI":"10.1099\/mic.0.001675","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:16:53Z","timestamp":1774264613000},"source":"Crossref","is-referenced-by-count":2,"title":["Bogland plant Tormentil inhibits multidrug-resistant pathogen growth and potentiates antibiotics by disrupting iron homeostasis"],"prefix":"10.1099","volume":"172","author":[{"given":"Kavita","family":"Gadar","sequence":"first","affiliation":[{"name":"Antimicrobial Innovations Centre, Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, Uxbridge, UB8 3PH, 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