{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T16:48:34Z","timestamp":1786553314683,"version":"build-2736575974"},"reference-count":90,"publisher":"Microbiology Society","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"crossref","award":["IN209713"],"award-info":[{"award-number":["IN209713"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"crossref","award":["IN213516"],"award-info":[{"award-number":["IN213516"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"crossref","award":["IN227525"],"award-info":[{"award-number":["IN227525"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"crossref","award":["749442"],"award-info":[{"award-number":["749442"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"crossref","award":["FC-2015-2\/950"],"award-info":[{"award-number":["FC-2015-2\/950"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,12]]},"abstract":"<jats:title>Graphical Abstract<\/jats:title>\n                  <jats:p>\n                    The CTS1 type VI secretion system of\n                    <jats:italic>Citrobacter rodentium<\/jats:italic>\n                    is organized into the divergent clusters:\n                    <jats:italic>cts1L<\/jats:italic>\n                    and\n                    <jats:italic>cts1R<\/jats:italic>\n                    . Multiple promoters coordinate\n                    <jats:italic>cts1<\/jats:italic>\n                    expression: four are located in the divergent regulatory region, and four additional promoters reside within\n                    <jats:italic>cts1R<\/jats:italic>\n                    .\n                    <jats:italic>cts1<\/jats:italic>\n                    is silenced by H-NS and activated by CpxR when repression is relieved.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"mic001756-f1.png\"\/>\n                  <\/jats:p>","DOI":"10.1099\/mic.0.001756","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T16:15:41Z","timestamp":1786551341000},"source":"Crossref","is-referenced-by-count":0,"title":["The divergent cts1 type VI secretion system locus of Citrobacter rodentium is controlled by multiple promoters that are silenced by H-NS, with CpxR contributing to their activation upon derepression"],"prefix":"10.1099","volume":"172","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0903-7004","authenticated-orcid":false,"given":"Stephanie","family":"Ortiz-Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Departamento de Microbiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Morelos, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7373-803X","authenticated-orcid":false,"given":"Diana Sabina","family":"Carrasco-Navarro","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Morelos, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L.","family":"Puente","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Morelos, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.001151"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.000789"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-023-03354-2"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2007\/006585-0"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-10-104"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1001068"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.376368"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061086"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.02504-12"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076767"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.053983-0"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00777-19"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00370-10"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.001376"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.080028-0"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14985"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.15255"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2010.00117"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-016-1236-2"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110731"},{"key":"R21","first-page":"4352","article-title":"Morphogenesis of early 1, 2-dimethylhydrazine-induced lesions and latent period reduction of colon carcinogenesis in mice by a variant of Citrobacter freundii","volume":"37","author":"Barthold","year":"1977","journal-title":"Cancer Res"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00625.x"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3315"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.210"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.06.018"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01144-09"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1996.tb02491.x"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02710-22"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007526"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1598"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28747-1"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1038\/nature05283"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020081"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1038\/srep00509"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.04970"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1128\/JB.02486-14"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2009.06754.x"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1883510"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004605"},{"key":"R40","volume-title":"Gen Metagenomics and Its Applications in Agriculture, Biomedicine and Environmental Studies","author":"Solovyev","year":"2011"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1128\/ecosalplus.esp-0039-2020"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.041"},{"key":"R43","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-021-00898-9"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00313"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1186\/s13567-019-0658-7"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2018.00320"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty496"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014998107"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1007\/s00203-016-1226-4"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006246"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1111\/lam.12316"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00198-15"},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00065-13"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy534"},{"key":"R55","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808215105"},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-2920.2009.02064.x"},{"key":"R57","article-title":"IDR 2025;Volume 18:2997\u20133011. 10.2147\/IDR.S512650","author":"Zhang"},{"key":"R58","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03548-25"},{"key":"R59","doi-asserted-by":"publisher","DOI":"10.1007\/s12275-022-2109-9"},{"key":"R60","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2019.00126"},{"key":"R61","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00654-17"},{"key":"R62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003589"},{"key":"R63","doi-asserted-by":"publisher","DOI":"10.1101\/gad.234336.113"},{"key":"R64","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac180"},{"key":"R65","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00512-20"},{"key":"R66","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq810"},{"key":"R67","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.20.5466-5472.1998"},{"key":"R68","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr390"},{"key":"R69","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203487200"},{"key":"R70","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00798-08"},{"key":"R71","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.60024"},{"key":"R72","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211584"},{"key":"R73","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.10.020"},{"key":"R74","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.200352"},{"key":"R75","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1079390"},{"key":"R76","doi-asserted-by":"publisher","DOI":"10.1002\/bit.22966"},{"key":"R77","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200611121"},{"key":"R78","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.194092"},{"key":"R79","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M406390200"},{"key":"R80","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.042521699"},{"key":"R81","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01296-10"},{"key":"R82","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00406-09"},{"key":"R83","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00194-15"},{"key":"R84","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.14182"},{"key":"R85","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00314-22"},{"key":"R86","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01031-19"},{"key":"R87","doi-asserted-by":"publisher","DOI":"10.1128\/iai.61.6.2486-2492.1993"},{"key":"R88","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.12.4645"},{"key":"R89","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23068-0"},{"key":"R90","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(95)00389-n"}],"container-title":["Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/mic.0.001756?crawler=true&mimetype=application\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T16:15:44Z","timestamp":1786551344000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/mic.0.001756"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":90,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8,12]]}},"URL":"https:\/\/doi.org\/10.1099\/mic.0.001756","relation":{},"ISSN":["1350-0872","1465-2080"],"issn-type":[{"value":"1350-0872","type":"print"},{"value":"1465-2080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]}}}