{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T22:11:58Z","timestamp":1767046318194},"reference-count":43,"publisher":"Microbiology Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6,1]]},"abstract":"<jats:p>\n                  <jats:italic>Helicobacter pylori<\/jats:italic> is a motile Gram-negative bacterium that colonizes and persists in the human gastric mucosa. The flagellum gene regulatory circuitry of <jats:italic>H. pylori<\/jats:italic> is unique in many aspects compared with the <jats:italic>Salmonella\/Escherichia coli<\/jats:italic> paradigms, and some regulatory checkpoints remain unclear. FliK controls the hook length during flagellar assembly. Microarray analysis of a <jats:italic>fliK<\/jats:italic>-null mutant revealed increased transcription of genes under the control of the <jats:italic>\u03c3<\/jats:italic>\n                  <jats:sup>54<\/jats:sup> sigma factor RpoN. This sigma factor has been shown to be responsible for transcription of the class II flagellar genes, including <jats:italic>flgE<\/jats:italic> and <jats:italic>flaB<\/jats:italic>. No genes higher in the flagellar hierarchy had altered expression, suggesting specific and localized FliK-dependent feedback on the RpoN regulon. FliK thus appears to be involved in three processes: hook-length control, export substrate specificity and control of RpoN transcriptional activity.<\/jats:p>","DOI":"10.1099\/mic.0.026062-0","type":"journal-article","created":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T18:09:04Z","timestamp":1243879744000},"page":"1901-1911","source":"Crossref","is-referenced-by-count":11,"title":["Effect of FliK mutation on the transcriptional activity of the \u03c3\n            54 sigma factor RpoN in Helicobacter pylori"],"prefix":"10.1099","volume":"155","author":[{"given":"Francois P.","family":"Douillard","sequence":"first","affiliation":[{"name":"Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, Western Road, Cork, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kieran A.","family":"Ryan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Alimentary Pharmabiotic Centre, University College Cork, 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