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A survey of the diversity of the fHbp gene and the encoded protein in a representative sample of meningococcal isolates confirmed that variability in this protein is structured into two or three major groups, each with a substantial number of alleles that have some association with meningococcal clonal complexes and serogroups. A unified nomenclature scheme was devised to catalogue this diversity. Analysis of recombination and selection on the allele sequences demonstrated that parts of the gene are subject to positive selection, consistent with immune selection on the protein generating antigenic variation, particularly in the C-terminal region of the peptide sequence. The highest levels of selection were observed in regions corresponding to epitopes recognized by previously described bactericidal monoclonal antibodies.<\/jats:p>","DOI":"10.1099\/mic.0.027995-0","type":"journal-article","created":{"date-parts":[[2009,11,3]],"date-time":"2009-11-03T22:52:21Z","timestamp":1257288741000},"page":"4155-4169","source":"Crossref","is-referenced-by-count":73,"title":["Variation of the factor H-binding protein of Neisseria meningitidis"],"prefix":"10.1099","volume":"155","author":[{"given":"Carina","family":"Brehony","sequence":"first","affiliation":[{"name":"Department of Zoology, University of Oxford, OX1 3PS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Human Genetics, University of Chicago, 920 East 58th Street, CLSC #410, Chicago, IL 60637, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin C. 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