{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T15:32:33Z","timestamp":1776958353014,"version":"3.51.4"},"reference-count":79,"publisher":"Microbiology Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:p><jats:italic>Neisseria gonorrhoeae<\/jats:italic>encodes a number of important genes that aid in survival during times of oxidative stress. The same immune cells capable of oxygen-dependent killing mechanisms also have the capacity to generate reactive nitrogen species (RNS) that may function antimicrobially. F62 and eight additional gonococcal strains displayed a high level of resistance to peroxynitrite, while<jats:italic>Neisseria meningitidis<\/jats:italic>and<jats:italic>Escherichia coli<\/jats:italic>showed a four- to seven-log and a four-log decrease in viability, respectively. Mutation of gonococcal orthologues that are known or suspected to be involved in RNS defence in other bacteria (<jats:italic>ahpC, dnrN<\/jats:italic>and<jats:italic>msrA<\/jats:italic>) resulted in no loss of viability, suggesting that<jats:italic>N. gonorrhoeae<\/jats:italic>has a novel mechanism of resistance to peroxynitrite. Whole-cell extracts of F62 prevented the oxidation of dihydrorhodamine, and decomposition of peroxynitrite was not dependent on<jats:italic>ahpC, dnrN<\/jats:italic>or<jats:italic>msrA<\/jats:italic>. F62 grown in co-culture with<jats:italic>E. coli<\/jats:italic>strain DH10B was shown to protect<jats:italic>E. coli<\/jats:italic>viability 10-fold. Also, peroxynitrite treatment of F62 did not result in accumulation of nitrated proteins, suggesting that an active peroxynitrite reductase is responsible for peroxynitrite decomposition rather than a protein sink for amino acid modification.<\/jats:p>","DOI":"10.1099\/mic.0.028092-0","type":"journal-article","created":{"date-parts":[[2009,7,29]],"date-time":"2009-07-29T01:51:17Z","timestamp":1248832277000},"page":"2532-2545","source":"Crossref","is-referenced-by-count":10,"title":["Resistance to peroxynitrite in Neisseria gonorrhoeae"],"prefix":"10.1099","volume":"155","author":[{"given":"Kenneth R.","family":"Barth","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent M.","family":"Isabella","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lori F.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia L.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, School of Medicine and Dentistry, University of Rochester, Box 672, 601 Elmwood Avenue, Rochester, NY 14642, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.lfs.2003.10.042","article-title":"iNOS-mediated nitric oxide production and its 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