{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:28:29Z","timestamp":1791822509829,"version":"4.3.4"},"reference-count":65,"publisher":"Microbiology Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12,1]]},"abstract":"<jats:p>\n                    For successful infection,\n                    <jats:italic>Salmonella enterica<\/jats:italic>\n                    secretes and injects effector proteins into host cells by two distinct type three secretion systems (T3SSs) located on\n                    <jats:italic>Salmonella<\/jats:italic>\n                    pathogenicity islands (SPIs)-1 and -2. The SPI-2 T3SS is involved in intracellular survival of\n                    <jats:italic>S. enterica<\/jats:italic>\n                    serovar Typhimurium and systemic disease. As little is known regarding the function of the SPI-2 T3SS from\n                    <jats:italic>S. enterica<\/jats:italic>\n                    serovar Typhi, the aetiological agent of typhoid fever, we investigated its role for survival in human macrophages. Mutations in the translocon (\n                    <jats:italic>sseB<\/jats:italic>\n                    ), basal secretion apparatus (\n                    <jats:italic>ssaR<\/jats:italic>\n                    ) and regulator (\n                    <jats:italic>ssrB<\/jats:italic>\n                    ) did not result in any reduction in survival under many of the conditions tested. Similar results were obtained with another\n                    <jats:italic>S.<\/jats:italic>\n                    Typhi strain or by using human primary cells. Results were corroborated based on complete deletion of the SPI-2 T3SS. Surprisingly, the data suggest that the SPI-2 T3SS of\n                    <jats:italic>S.<\/jats:italic>\n                    Typhi is not required for survival in human macrophages.\n                  <\/jats:p>","DOI":"10.1099\/mic.0.041624-0","type":"journal-article","created":{"date-parts":[[2010,9,3]],"date-time":"2010-09-03T20:16:18Z","timestamp":1283544978000},"page":"3689-3698","source":"Crossref","is-referenced-by-count":68,"title":["Intracellular survival of Salmonella enterica serovar Typhi in human macrophages is independent of Salmonella pathogenicity island (SPI)-2"],"prefix":"10.1099","volume":"156","author":[{"given":"Chantal G.","family":"Forest","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, University of Montreal, C.P. 6128 Succursale Centre-Ville, Montreal, QC H3C 3J7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elyse","family":"Ferraro","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Montreal, C.P. 6128 Succursale Centre-Ville, Montreal, QC H3C 3J7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien C.","family":"Sabbagh","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Montreal, C.P. 6128 Succursale Centre-Ville, Montreal, QC H3C 3J7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"France","family":"Daigle","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, University of Montreal, C.P. 6128 Succursale Centre-Ville, Montreal, QC H3C 3J7, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1084\/jem.179.2.601","article-title":"Salmonella stimulate macrophage macropinocytosis and persist within spacious 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