{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T14:10:32Z","timestamp":1695737432279},"reference-count":47,"publisher":"Microbiology Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,3,1]]},"abstract":"<jats:p>\n                  <jats:italic>Salmonella enterica<\/jats:italic> serovar Typhi (<jats:italic>S.<\/jats:italic> Typhi) is the aetiological agent of typhoid fever in humans. This bacterium is also able to persist in its host, causing a chronic disease by colonizing the spleen, liver and gallbladder, in the last of which the pathogen forms biofilms in order to survive the bile. Several genetic components, including the <jats:italic>yihU<\/jats:italic>\u2013<jats:italic>yshA<\/jats:italic> genes, have been suggested to be involved in the survival of <jats:italic>Salmonella<\/jats:italic> in the gallbladder. In this work we describe how the <jats:italic>yihU<\/jats:italic>\u2013<jats:italic>yshA<\/jats:italic> gene cluster forms a transcriptional unit regulated positively by the cAMP receptor global regulator CRP (cAMP receptor protein). The results obtained show that two CRP-binding sites on the regulatory region of the <jats:italic>yihU<\/jats:italic>\u2013<jats:italic>yshA<\/jats:italic> operon are required to promote transcriptional activation. In this work we also demonstrate that the <jats:italic>yihU<\/jats:italic>\u2013<jats:italic>yshA<\/jats:italic> transcriptional unit is carbon catabolite-repressed in <jats:italic>Salmonella,<\/jats:italic> indicating that it forms part of the CRP regulon in enteric bacteria.<\/jats:p>","DOI":"10.1099\/mic.0.046045-0","type":"journal-article","created":{"date-parts":[[2010,12,10]],"date-time":"2010-12-10T02:54:10Z","timestamp":1291949650000},"page":"636-647","source":"Crossref","is-referenced-by-count":5,"title":["cAMP receptor protein (CRP) positively regulates the yihU\u2013yshA operon in Salmonella enterica serovar Typhi"],"prefix":"10.1099","volume":"157","author":[{"given":"J. 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L.","family":"Calder\u00f3n","sequence":"additional","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda Molecular, Departamento de Ciencias Biol\u00f3gicas, Facultad de Ciencias Biol\u00f3gicas, Universidad Andr\u00e9s Bello, Santiago, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Calva","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda Molecular, Instituto de Biotecnolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Cuernavaca, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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