{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T15:07:26Z","timestamp":1793372846668,"version":"4.5.0"},"reference-count":50,"publisher":"Microbiology Society","issue":"10","funder":[{"name":"NIH","award":["T32GM08704"],"award-info":[{"award-number":["T32GM08704"]}]},{"name":"NIH","award":["AI25096"],"award-info":[{"award-number":["AI25096"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10,1]]},"abstract":"<jats:p>The acute diarrhoeal disease cholera is caused by the aquatic pathogen <jats:italic>Vibrio cholerae<\/jats:italic> upon ingestion of contaminated food or water by the human host. The mechanisms by which <jats:italic>V. cholerae<\/jats:italic> is able to persist and survive in the host and aquatic environments have been studied for years; however, little is known about the factors involved in the adaptation or response of <jats:italic>V. cholerae<\/jats:italic> transitioning between these two environments. The transition from bacillary to coccoid morphology is thought to be one mechanism of survival that <jats:italic>V. cholerae<\/jats:italic> uses in response to environmental stress. Coccoid morphology has been observed for <jats:italic>V. cholerae<\/jats:italic> while in a viable but non-culturable (VBNC) state, during times of nutrient limitation, and in the water-diluted stool of cholera-infected patients. In this study we sought conditions to study the coccoid morphology of <jats:italic>V. cholerae<\/jats:italic>, and found that coccoid-shaped cells can express and produce the virulence factor toxin co-regulated pilus (TCP) and are able to colonize the infant mouse to the same extent as bacillus-shaped cells. This study suggests that TCP may be one factor that <jats:italic>V. cholerae<\/jats:italic> utilizes for adaptation and survival during the transition between the host and the aquatic environment.<\/jats:p>","DOI":"10.1099\/mic.0.048561-0","type":"journal-article","created":{"date-parts":[[2011,7,22]],"date-time":"2011-07-22T00:47:35Z","timestamp":1311295655000},"page":"2942-2953","source":"Crossref","is-referenced-by-count":46,"title":["Nutrient-dependent, rapid transition of Vibrio cholerae to coccoid morphology and expression of the toxin co-regulated pilus in this form"],"prefix":"10.1099","volume":"157","author":[{"given":"Shelly J.","family":"Krebs","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Dartmouth Medical School, Hanover, NH 03755, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald K.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Dartmouth 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