{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:53:00Z","timestamp":1789854780413,"version":"4.0.1"},"reference-count":134,"publisher":"Microbiology Society","issue":"8","funder":[{"name":"IBD-LabNet"},{"name":"ECDC-funded Invasive Bacterial Disease Laboratory Network"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8,1]]},"abstract":"<jats:p>Invasive disease caused by the encapsulated bacteria<jats:italic>Neisseria meningitidis<\/jats:italic>,<jats:italic>Haemophilus influenzae<\/jats:italic>and<jats:italic>Streptococcus pneumoniae<\/jats:italic>remains an important cause of morbidity and mortality worldwide, despite the introduction of successful conjugate polysaccharide vaccines that target disease-associated strains. In addition, resistance, or more accurately reduced susceptibility, to therapeutic antibiotics is spreading in populations of these organisms. There is therefore a continuing requirement for the surveillance of vaccine and non-vaccine antigens and antibiotic susceptibilities among isolates from invasive disease, which is only partially met by conventional methods. This need can be met with molecular and especially nucleotide sequence-based typing methods, which are fully developed in the case of<jats:italic>N. meningitidis<\/jats:italic>and which could be more widely deployed in clinical laboratories for<jats:italic>S. pneumoniae<\/jats:italic>and<jats:italic>H. influenzae<\/jats:italic>.<\/jats:p>","DOI":"10.1099\/mic.0.050518-0","type":"journal-article","created":{"date-parts":[[2011,5,27]],"date-time":"2011-05-27T02:36:09Z","timestamp":1306463769000},"page":"2181-2195","source":"Crossref","is-referenced-by-count":34,"title":["Molecular typing methods for outbreak detection and surveillance of invasive disease caused by Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae, a review"],"prefix":"10.1099","volume":"157","author":[{"given":"Odile B.","family":"Harrison","sequence":"first","affiliation":[{"name":"Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela B.","family":"Brueggemann","sequence":"additional","affiliation":[{"name":"Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique A.","family":"Caugant","sequence":"additional","affiliation":[{"name":"Department of Bacteriology and Immunology, Norwegian Institute of Public Health, PO Box 4404 Nydalen, NO-0403 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie","family":"van der Ende","sequence":"additional","affiliation":[{"name":"Academic Medical Center, Department of Medical Microbiology, Reference Laboratory for Bacterial Meningitis, PO Box 22660, 1100 DD Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Frosch","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Hygiene und Mikrobiologie, Universit\u00e4t W\u00fcrzburg, Josef-Schneider Strasse 2, 97080 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Gray","sequence":"additional","affiliation":[{"name":"Meningococcal Reference Unit, Health Protection Agency, PO Box 209, Clinical Sciences Building 2, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WZ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Heuberger","sequence":"additional","affiliation":[{"name":"\u00d6sterreichische Agentur f\u00fcr Gesundheit und Ern\u00e4hrungssicherheit GmbH, Bereich Humanmedizin, Institut f\u00fcr medizinische Mikrobiologie und Hygiene, Beethovenstra\u00dfe 6, A-8010 Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Krizova","sequence":"additional","affiliation":[{"name":"National Reference Laboratory for Meningococcal Infections, National Institute of Public Health, Srobarova 48, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Olcen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Clinical Microbiology and Immunology, Orebro University Hospital, SE-701 85 Orebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Slack","sequence":"additional","affiliation":[{"name":"Respiratory and Systemic Infection Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhamed-Kheir","family":"Taha","sequence":"additional","affiliation":[{"name":"Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin C. 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