{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:48:32Z","timestamp":1789786112997,"version":"4.0.1"},"reference-count":62,"publisher":"Microbiology Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1,1]]},"DOI":"10.1099\/mic.0.2006\/000927-0","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T20:09:13Z","timestamp":1166731753000},"page":"29-41","source":"Crossref","is-referenced-by-count":92,"title":["The iron- and cAMP-regulated gene SIT1 influences ferrioxamine B utilization, melanization and cell wall structure in Cryptococcus neoformans"],"prefix":"10.1099","volume":"153","author":[{"given":"Kristin L.","family":"Tangen","sequence":"first","affiliation":[{"name":"Michael Smith Laboratories, Department of Microbiology and Immunology, and Faculty of Land and Food Systems, University of British Columbia, Vancouver BC V6T 1Z4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Hee","family":"Jung","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories, Department of Microbiology and Immunology, and Faculty of Land and Food Systems, University of British Columbia, Vancouver BC V6T 1Z4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita P.","family":"Sham","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories, Department of Microbiology and Immunology, and Faculty of Land and Food Systems, University of British Columbia, Vancouver BC V6T 1Z4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshun","family":"Lian","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories, Department of Microbiology and Immunology, and Faculty of Land and Food Systems, University of British Columbia, Vancouver BC V6T 1Z4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"Kronstad","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories, Department of Microbiology and Immunology, and Faculty of Land and Food Systems, University of British Columbia, Vancouver BC V6T 1Z4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1101\/gad.11.23.3206","article-title":"Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP","volume":"11","author":"Alspaugh","year":"1997","journal-title":"Genes Dev"},{"key":"R2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1128\/EC.1.1.75-84.2002","article-title":"Adenylyl cyclase functions downstream of the G alpha protein Gpa1 and controls mating and pathogenicity of Cryptococcus neoformans","volume":"1","author":"Alspaugh","year":"2002","journal-title":"Eukaryot Cell"},{"key":"R3","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J Mol Biol"},{"key":"R4","doi-asserted-by":"crossref","first-page":"43049","DOI":"10.1074\/jbc.M108701200","article-title":"Identification of a Candida albicans ferrichrome transporter and its characterization by expression in Saccharomyces cerevisiae","volume":"276","author":"Ardon","year":"2001","journal-title":"J Biol Chem"},{"key":"R5","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/432811a","article-title":"Cell biology: iron thievery","volume":"432","author":"Barasch","year":"2004","journal-title":"Nature"},{"key":"R6","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jinf.2004.07.013","article-title":"Comparative analysis of pathogenicity of Cryptococcus neoformans serotypes A, D and AD in murine cryptococcosis","volume":"51","author":"Barchiesi","year":"2005","journal-title":"J Infect"},{"key":"R7","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1128\/EC.2.4.655-663.2003","article-title":"A yeast under cover: the capsule of Cryptococcus neoformans","volume":"2","author":"Bose","year":"2003","journal-title":"Eukaryot Cell"},{"key":"R8","doi-asserted-by":"crossref","DOI":"10.1128\/9781555818241","volume-title":"Cryptococcus neoformans","author":"Casadevall","year":"1998"},{"key":"R9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1006\/abio.1993.1246","article-title":"A comparison of bathophenanthrolinedisulfonic acid and ferrozine as chelators of iron(II) in reduction reactions","volume":"211","author":"Cowart","year":"1993","journal-title":"Anal Biochem"},{"key":"R10","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1099\/00221287-148-8-2607","article-title":"A PCR-based strategy to generate integrative targeting alleles with large regions of homology","volume":"148","author":"Davidson","year":"2002","journal-title":"Microbiology"},{"key":"R11","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1128\/MCB.21.9.3179-3191.2001","article-title":"Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans","volume":"21","author":"D'Souza","year":"2001","journal-title":"Mol Cell Biol"},{"key":"R12","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1021\/bi047731m","article-title":"Microstructure of cell wall-associated melanin in the human pathogenic fungus Cryptococcus neoformans","volume":"44","author":"Eisenman","year":"2005","journal-title":"Biochemistry"},{"key":"R13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/00001432-200304000-00005","article-title":"Melanin and fungi","volume":"16","author":"Gomez","year":"2003","journal-title":"Curr Opin Infect Dis"},{"key":"R14","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1007\/s00253-003-1335-2","article-title":"Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophore in iron uptake and storage","volume":"62","author":"Haas","year":"2003","journal-title":"Appl Microbiol Biotechnol"},{"key":"R15","doi-asserted-by":"crossref","first-page":"28547","DOI":"10.1074\/jbc.M503404200","article-title":"The role and mechanism of diacylglycerol-protein kinase C1 signaling in melanogenesis by Cryptococcus neoformans","volume":"280","author":"Heung","year":"2005","journal-title":"J Biol Chem"},{"key":"R16","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.1128\/IAI.70.9.5246-5255.2002","article-title":"The siderophore iron transporter of Candida albicans (Sit1p\/Arn1p) mediates uptake of ferrichrome-type siderophores and is required for epithelial invasion","volume":"70","author":"Heymann","year":"2002","journal-title":"Infect Immun"},{"key":"R17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1128\/EC.3.1.14-26.2004","article-title":"Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor prodution in two varieties of the fungal pathogen Cryptococcus neoformans","volume":"3","author":"Hicks","year":"2004","journal-title":"Eukaryot Cell"},{"key":"R18","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1128\/IAI.72.3.1402-1408.2004","article-title":"Survival of Aspergillus fumigatus in serum involves removal of iron from transferrin: the role of siderophores","volume":"72","author":"Hissen","year":"2004","journal-title":"Infect Immun"},{"key":"R19","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1128\/IAI.73.9.5493-5503.2005","article-title":"The Aspergillus fumigatus siderophore biosynthetic gene sidA , encoding l-ornithine N5-oxygenase, is required for virulence","volume":"73","author":"Hissen","year":"2005","journal-title":"Infect Immun"},{"key":"R20","doi-asserted-by":"crossref","first-page":"30598","DOI":"10.1074\/jbc.M204545200","article-title":"Characterization and functional analysis of the siderophore-Fe transporter CaArn1p in Candida albicans","volume":"277","author":"Hu","year":"2002","journal-title":"J Biol Chem"},{"key":"R21","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1128\/CMR.13.4.708","article-title":"Pathogenic roles for fungal melanins","volume":"13","author":"Jacobson","year":"2000","journal-title":"Clin Microbiol Rev"},{"key":"R22","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1080\/02681219680000491","article-title":"Discordant regulation of phenoloxidase and capsular polysaccharide in Cryptococcus neoformans","volume":"34","author":"Jacobson","year":"1996","journal-title":"J Med Vet Mycol"},{"key":"R23","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1080\/02681218780000501","article-title":"Extracellular iron chelation in Cryptococcus neoformans","volume":"25","author":"Jacobson","year":"1987","journal-title":"J Med Vet Mycol"},{"key":"R24","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1128\/IAI.66.9.4169-4175.1998","article-title":"Ferrous iron uptake in Cryptococcus neoformans","volume":"66","author":"Jacobson","year":"1998","journal-title":"Infect Immun"},{"key":"R25","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.femsyr.2004.04.003","article-title":"Cryptococcus neoformans capsule biosynthesis and regulation","volume":"4","author":"Janbon","year":"2004","journal-title":"FEMS Yeast Res"},{"key":"R26","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1093\/emboj\/cdf382","article-title":"Ferrichrome induces endosome to plasma membrane cycling of the ferrichrome tranporter, Arn1p, in Saccharomyces cerevisiae","volume":"21","author":"Kim","year":"2002","journal-title":"EMBO J"},{"key":"R27","doi-asserted-by":"crossref","first-page":"5482","DOI":"10.1128\/IAI.73.9.5482-5492.2005","article-title":"Iron acquisition from transferrin by Candida albicans depends on the reductive pathway","volume":"73","author":"Knight","year":"2005","journal-title":"Infect Immun"},{"key":"R28","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1046\/j.1365-2958.2003.03368.x","article-title":"Molecular mechanisms of iron uptake in fungi","volume":"47","author":"Kosman","year":"2003","journal-title":"Mol Microbiol"},{"key":"R29","doi-asserted-by":"crossref","first-page":"3455","DOI":"10.1099\/00221287-144-12-3455","article-title":"Siderophore-mediated iron uptake in Saccharomyces cerevisiae : the SIT1 gene encodes a ferrioxamine B permease that belongs to the major facilitator superfamily","volume":"144","author":"Lesuisse","year":"1998","journal-title":"Microbiology"},{"key":"R30","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1099\/00221287-147-2-289","article-title":"Siderophore uptake and use by the yeast Saccharomyces cerevisiae","volume":"147","author":"Lesuisse","year":"2001","journal-title":"Microbiology"},{"key":"R31","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1111\/j.1365-2958.2004.04474.x","article-title":"Iron-regulated transcription and capsule formation in the fungal pathogen Cryptococcus neoformans","volume":"55","author":"Lian","year":"2005","journal-title":"Mol Microbiol"},{"key":"R32","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.1128\/IAI.67.11.6034-6039.1999","article-title":"Laccase protects Cryptococcus neoformans from antifungal activity of alveolar macrophages","volume":"11","author":"Liu","year":"1999","journal-title":"Infect Immun"},{"key":"R33","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(\u2212delta delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"R34","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1126\/science.1103773","article-title":"The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans","volume":"307","author":"Loftus","year":"2005","journal-title":"Science"},{"key":"R35","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1128\/IAI.72.3.1693-1699.2004","article-title":"CNLAC1 is required for extrapulmonary dissemination of Cryptococcus neoformans but not pulmonary persistence","volume":"3","author":"Noverr","year":"2004","journal-title":"Infect Immun"},{"key":"R36","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1128\/JCM.10.5.724-729.1979","article-title":"Regulation of melanin production by Cryptococcus neoformans","volume":"10","author":"Nurudeen","year":"1979","journal-title":"J Clin Microbiol"},{"key":"R37","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1128\/IAI.67.5.2357-2365.1999","article-title":"Genetic and physiologic characterization of ferric\/cupric reductase constitutive mutants of Cryptococcus neoformans","volume":"5","author":"Nyhus","year":"1999","journal-title":"Infect Immun"},{"key":"R38","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1128\/IAI.65.2.434-438.1997","article-title":"Ferric iron reduction by Cryptococcus neoformans","volume":"65","author":"Nyhus","year":"1997","journal-title":"Infect Immun"},{"key":"R39","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s00294-004-0554-0","article-title":"Sed1p interacts with Arn3p physically and mediates ferrioxamine B uptake in Saccharomyces cerevisiae","volume":"47","author":"Park","year":"2005","journal-title":"Curr Genet"},{"key":"R40","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.femsim.2005.06.005","article-title":"Cryptococcus neoformans: a sugar-coated killer with designer genes","volume":"45","author":"Perfect","year":"2005","journal-title":"FEMS Immunol Med Microbiol"},{"key":"R41","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1128\/JB.150.3.1212-1220.1982","article-title":"Biochemical studies of phenoloxidase and utilization of catecholamines in Cryptococcus neoformans","volume":"150","author":"Polacheck","year":"1982","journal-title":"J Bacteriol"},{"key":"R42","doi-asserted-by":"crossref","first-page":"49244","DOI":"10.1074\/jbc.M109220200","article-title":"Three cell wall mannoproteins facilitate the uptake of iron in Saccharomyces cerevisiae","volume":"276","author":"Protchenko","year":"2001","journal-title":"J Biol Chem"},{"key":"R43","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1128\/EC.4.1.190-201.2005","article-title":"Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade","volume":"4","author":"Pukkila-Worley","year":"2005","journal-title":"Eukaryot Cell"},{"key":"R44","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.288.5468.1062","article-title":"A high-affinity iron permease essential for Candida albicans virulence","volume":"288","author":"Ramanan","year":"2000","journal-title":"Science"},{"key":"R45","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1146\/annurev.micro.54.1.881","article-title":"Iron metabolism in pathogenic bacteria","volume":"54","author":"Ratledge","year":"2000","journal-title":"Annu Rev Microbiol"},{"key":"R46","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.1073\/pnas.100113397","article-title":"The yeast A kinases differentially regulate iron uptake and respiratory function","volume":"97","author":"Robertson","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R47","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1084\/jem.184.2.377","article-title":"Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans","volume":"184","author":"Salas","year":"1996","journal-title":"J Exp Med"},{"key":"R48","volume-title":"Molecular Cloning: a Laboratory Manual","author":"Sambrook","year":"1989"},{"key":"R49","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1084\/jem.20041242","article-title":"Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence","volume":"200","author":"Schrettl","year":"2004","journal-title":"J Exp Med"},{"key":"R50","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1126\/science.271.5255.1552","article-title":"A permease-oxidase complex involved in high-affinity iron uptake in yeast","volume":"271","author":"Stearman","year":"1996","journal-title":"Science"},{"key":"R51","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1128\/JB.175.5.1405-1411.1993","article-title":"Gene transfer in Cryptococcus neoformans by use of biolistic delivery of DNA","volume":"175","author":"Toffaletti","year":"1993","journal-title":"J Bacteriol"},{"key":"R52","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1128\/IAI.60.3.1101-1108.1992","article-title":"Molecular and genetic analysis of URA5 transformants of Cryptococcus neoformans","volume":"60","author":"Varma","year":"1992","journal-title":"Infect Immun"},{"key":"R53","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/infdis\/167.1.186","article-title":"Regulation of cryptococcal capsular polysaccharide by iron","volume":"167","author":"Vartivarian","year":"1993","journal-title":"J Infect Dis"},{"key":"R54","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1111\/j.1365-2958.2005.04779.x","article-title":"Novel gene functions required for melanization of the human pathogen Cryptococcus neoformans","volume":"57","author":"Walton","year":"2005","journal-title":"Mol Microbiol"},{"key":"R55","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2741\/A231","article-title":"Laccase and melanin in the pathogensis of Cryptococcus neoformans","volume":"1","author":"Williamson","year":"1997","journal-title":"Front Biosci"},{"key":"R56","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.fgb.2004.08.001","article-title":"Double-joint PCR: a PCR-based molecular tool for gene manipulations in filamentous fungi","volume":"41","author":"Yu","year":"2004","journal-title":"Fungal Genet Biol"},{"key":"R57","doi-asserted-by":"crossref","first-page":"10709","DOI":"10.1074\/jbc.275.14.10709","article-title":"Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae . Evidence for two pathways of iron uptake","volume":"275","author":"Yun","year":"2000a","journal-title":"J Biol Chem"},{"key":"R58","doi-asserted-by":"crossref","first-page":"16354","DOI":"10.1074\/jbc.M001456200","article-title":"Siderophore-iron uptake in Saccharomyces cerevisiae . Identification of ferrichrome and fusarinine transporters","volume":"275","author":"Yun","year":"2000b","journal-title":"J Biol Chem"},{"key":"R59","doi-asserted-by":"crossref","first-page":"6155","DOI":"10.1128\/IAI.71.11.6155-6164.2003","article-title":"Induction of capsule growth in Cryptococcus neoformans by mammalian serum and CO2","volume":"71","author":"Zaragoza","year":"2003","journal-title":"Infect Immun"},{"key":"R60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.femsyr.2004.04.004","article-title":"Role of laccase in the biology and virulence of Cryptococcus neoformans","volume":"5","author":"Zhu","year":"2004","journal-title":"FEMS Yeast Res"},{"key":"R61","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1128\/IAI.69.9.5589-5596.2001","article-title":"Laccase of Cryptococcus neoformans is a cell wall-associated virulence factor","volume":"69","author":"Zhu","year":"2001","journal-title":"Infect Immun"},{"key":"R62","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1046\/j.1365-2958.2003.03340.x","article-title":"Copper-mediated reversal of defective laccase in a \u0394 vph1 avirulent mutant of Cryptococcus neoformans","volume":"47","author":"Zhu","year":"2003","journal-title":"Mol Microbiol"}],"container-title":["Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/mic.0.2006\/000927-0?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T14:18:37Z","timestamp":1587305917000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/mic.0.2006\/000927-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,1]]},"references-count":62,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1,1]]}},"URL":"https:\/\/doi.org\/10.1099\/mic.0.2006\/000927-0","relation":{},"ISSN":["1350-0872","1465-2080"],"issn-type":[{"value":"1350-0872","type":"print"},{"value":"1465-2080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,1]]}}}