{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:09:46Z","timestamp":1790474986109,"version":"4.1.0"},"reference-count":41,"publisher":"Microbiology Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,1]]},"DOI":"10.1099\/mic.0.2006\/003921-0","type":"journal-article","created":{"date-parts":[[2007,4,26]],"date-time":"2007-04-26T22:57:57Z","timestamp":1177628277000},"page":"1372-1381","source":"Crossref","is-referenced-by-count":52,"title":["Disruption of the Candida albicans ATC1 gene encoding a cell-linked acid trehalase decreases hypha formation and infectivity without affecting resistance to oxidative stress"],"prefix":"10.1099","volume":"153","author":[{"given":"Yolanda","family":"Pedre\u00f1o","sequence":"first","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Ecolog\u00eda, Universidad de Valencia, E-46100 Burjassot, Valencia, Spain"},{"name":"\u00c1rea de Microbiolog\u00eda, Facultad de Biolog\u00eda, Universidad de Murcia, E-30071 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Gonz\u00e1lez-P\u00e1rraga","sequence":"additional","affiliation":[{"name":"\u00c1rea de Microbiolog\u00eda, Facultad de Biolog\u00eda, Universidad de Murcia, E-30071 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Mart\u00ednez-Esparza","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica y Biolog\u00eda Molecular B e Inmunolog\u00eda, Universidad de Murcia, E-30071 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Sentandreu","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Ecolog\u00eda, Universidad de Valencia, E-46100 Burjassot, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eulogio","family":"Valent\u00edn","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Ecolog\u00eda, Universidad de Valencia, E-46100 Burjassot, Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Carlos","family":"Arg\u00fcelles","sequence":"additional","affiliation":[{"name":"\u00c1rea de Microbiolog\u00eda, Facultad de Biolog\u00eda, Universidad de Murcia, E-30071 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/13693780500138971","article-title":"An update on antifungal targets and mechanisms of resistance in Candida albicans","volume":"43","author":"Akins","year":"2005","journal-title":"Med Mycol"},{"key":"R2","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0923-2508(00)01150-5","article-title":"Changes in external trehalase activity during human serum-induced dimorphic transition in Candida albicans","volume":"151","author":"Alvarez-Peral","year":"2000","journal-title":"Res Microbiol"},{"key":"R3","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1099\/00221287-148-8-2599","article-title":"Protective role of trehalose during severe oxidative stress caused by hydrogen peroxide and the adaptive oxidative stress response in Candida albicans","volume":"148","author":"Alvarez-Peral","year":"2002","journal-title":"Microbiology"},{"key":"R4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s002030000192","article-title":"Physiological roles of trehalose in bacteria and yeasts: a comparative analysis","volume":"174","author":"Argu\u0308elles","year":"2000","journal-title":"Arch Microbiol"},{"key":"R5","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0923-2508(99)00105-9","article-title":"Trehalose hydrolysis is not required for human serum-induced dimorphic transition in Candida albicans : evidence from a tps1\/tps1 mutant deficient in trehalose synthesis","volume":"150","author":"Argu\u0308elles","year":"1999","journal-title":"Res Microbiol"},{"key":"R6","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1074\/jbc.M510360200","article-title":"Outer chain N -glycans are required for cell wall integrity and virulence of Candida albicans","volume":"281","author":"Bates","year":"2006","journal-title":"J Biol Chem"},{"key":"R7","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nrg948","article-title":"Candida albicans : a molecular revolution built on lessons from budding yeast","volume":"3","author":"Berman","year":"2002","journal-title":"Nat Rev Genet"},{"key":"R8","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1128\/JB.176.13.3895-3902.1994","article-title":"Trehalose-6-P synthase is dispensable for growth on glucose but not for spore germination in Schizosaccharomyces pombe","volume":"176","author":"Bla\u0301zquez","year":"1994","journal-title":"J Bacteriol"},{"key":"R9","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0966-842X(01)02094-7","article-title":"Virulence factors of Candida albicans","volume":"9","author":"Calderone","year":"2001","journal-title":"Trends Microbiol"},{"key":"R10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/02681219480000721","article-title":"Molecular biological and biochemical aspects of fungal dimorphism","volume":"32 (Suppl. 1","author":"Cannon","year":"1994","journal-title":"J Med Vet Mycol"},{"key":"R11","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nrmicro1426","article-title":"Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus","volume":"4","author":"Chauhan","year":"2006","journal-title":"Nat Rev Microbiol"},{"key":"R12","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/S0140-6736(03)14472-8","article-title":"Echinocandin antifungal drugs","volume":"362","author":"Denning","year":"2003","journal-title":"Lancet"},{"key":"R13","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1099\/00221287-143-12-3747","article-title":"A neutral trehalase gene from Candida albicans : molecular cloning, characterization and disruption","volume":"143","author":"Eck","year":"1997","journal-title":"Microbiology"},{"key":"R14","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S1473-3099(03)00801-6","article-title":"Epidemiology of Candida species infections in critically ill non-immunosuppressed patients","volume":"3","author":"Eggimann","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"R15","doi-asserted-by":"crossref","first-page":"17R","DOI":"10.1093\/glycob\/cwg047","article-title":"New insights on trehalose: a multifunctional molecule","volume":"13","author":"Elbein","year":"2003","journal-title":"Glycobiology"},{"key":"R16","first-page":"2209","article-title":"Dimorphism in Candida albicans : contribution of mannoproteins to the architecture of yeast and mycelial cell walls","volume":"131","author":"Elorza","year":"1985","journal-title":"J Gen Microbiol"},{"key":"R17","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1093\/genetics\/134.3.717","article-title":"Isogenic strain construction and gene mapping in Candida albicans","volume":"134","author":"Fonzi","year":"1993","journal-title":"Genetics"},{"key":"R18","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/yea.320110408","article-title":"Studies on the transformation of intact yeast cells by the LiAc\/SS-DNA\/PEG procedure","volume":"11","author":"Gietz","year":"1995","journal-title":"Yeast"},{"key":"R19","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1002\/yea.1029","article-title":"Role of antioxidant enzymatic defences against oxidative stress (H2O2) and the acquisition of oxidative tolerance in Candida albicans","volume":"20","author":"Gonza\u0301lez-Pa\u0301rraga,","year":"2003","journal-title":"Yeast"},{"key":"R20","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S1369-5274(02)00338-7","article-title":"Fungal morphogenesis and host invasion","volume":"5","author":"Gow","year":"2002","journal-title":"Curr Opin Microbiol"},{"key":"R21","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1046\/j.1469-8137.1999.00341.x","article-title":"Response of antioxidant systems and leaf water relations to NaCl stress in pea plants","volume":"141","author":"Herna\u0301ndez","year":"1999","journal-title":"New Phytol"},{"key":"R22","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1099\/00221287-148-11-3705","article-title":"Copper- and zinc-containing superoxide dismutase (Cu\/ZnSOD) is required for the protection of Candida albicans against oxidative stresses and the expression of its full virulence","volume":"148","author":"Hwang","year":"2002","journal-title":"Microbiology"},{"key":"R23","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0966-842X(98)01218-9","article-title":"Candida albicans hyphal formation and virulence: is there a clearly defined role?","volume":"6","author":"Kobayashi","year":"1998","journal-title":"Trends Microbiol"},{"key":"R24","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S0092-8674(00)80358-X","article-title":"Nonfilamentous C. albicans mutants are avirulent","volume":"90","author":"Lo","year":"1997","journal-title":"Cell"},{"key":"R25","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1086\/322606","article-title":"Trends in mortality due to invasive mycotic diseases in the United States, 1980-1997","volume":"33","author":"McNeil","year":"2001","journal-title":"Clin Infect Dis"},{"key":"R26","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1128\/CMR.18.1.163-194.2005","article-title":"Combination treatment of invasive fungal infections","volume":"18","author":"Mukherjee","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"R27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/1097-0061(20000315)16:4<325::AID-YEA538>3.0.CO;2-#","article-title":"CIp10, an efficient and convenient integrating vector for Candida albicans","volume":"16","author":"Murad","year":"2000","journal-title":"Yeast"},{"key":"R28","first-page":"313","article-title":"Candida species and virulence","volume":"360","author":"Odds","year":"1994","journal-title":"ASM News"},{"key":"R29","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0140-6736(05)67381-3","article-title":"Advances and challenges in management of invasive mycoses","volume":"366","author":"Patterson","year":"2005","journal-title":"Lancet"},{"key":"R30","doi-asserted-by":"crossref","first-page":"40852","DOI":"10.1074\/jbc.M400216200","article-title":"The ATC1 gene encodes a cell wall-linked acid trehalase required for growth on trehalose in Candida albicans","volume":"279","author":"Pedren\u0303o","year":"2004","journal-title":"J Biol Chem"},{"key":"R31","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1567-1364.2005.00025.x","article-title":"The cellular resistance against oxidative stress (H2O2) is independent of neutral trehalase (Ntc1p) activity in Candida albicans","volume":"6","author":"Pedren\u0303o","year":"2006","journal-title":"FEMS Yeast Res"},{"key":"R32","first-page":"1227","article-title":"Exo-(1\u21923)- \u03b2 -glucanase, autolysin and trehalase activities during yeast growth and germ-tube formation in Candida albicans","volume":"130","author":"Ram","year":"1984","journal-title":"J Gen Microbiol"},{"key":"R33","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1128\/IAI.50.2.541-544.1985","article-title":"Pathogenicity of morphological and auxotrophic mutants of Candida albicans in experimental infections","volume":"50","author":"Shepherd","year":"1985","journal-title":"Infect Immun"},{"key":"R34","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S1097-2765(00)80064-7","article-title":"Multiple effects of trehalose on protein folding in vitro and in vivo","volume":"1","author":"Singer","year":"1998","journal-title":"Mol Cell"},{"key":"R35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.tim.2004.05.008","article-title":"The distinct morphogenic states of Candida albicans","volume":"12","author":"Sudbery","year":"2004","journal-title":"Trends Microbiol"},{"key":"R36","first-page":"395","article-title":"Regulation of trehalose metabolism and its relevance to cell growth and function","volume-title":"The Mycota","volume":", vol.\u20053","author":"Thevelein","year":"1996"},{"key":"R37","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1128\/IAI.70.4.1772-1782.2002","article-title":"Disruption of the Candida albicans TPS2 gene encoding trehalose-6-phosphate phosphatase decreases infectivity without affecting hypha formation","volume":"70","author":"Van Dijck","year":"2002","journal-title":"Infect Immun"},{"key":"R38","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1128\/.61.2.170-192.1997","article-title":"Macrophages in resistance to candidiasis","volume":"61","author":"Va\u0301zquez-Torres","year":"1997","journal-title":"Microbiol Mol Biol Rev"},{"key":"R39","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0732-8893(99)00035-8","article-title":"Nosocomial fungal infections: candidemia","volume":"34","author":"Verduyn Lunel","year":"1999","journal-title":"Diagn Microbiol Infect Dis"},{"key":"R40","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1128\/JB.180.15.3809-3815.1998","article-title":"Disruption of the Candida albicans TPS1 gene encoding trehalose-6-phosphate synthase impairs formation of hyphae and decreases infectivity","volume":"180","author":"Zaragoza","year":"1998","journal-title":"J Bacteriol"},{"key":"R41","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1099\/00221287-148-5-1281","article-title":"Disruption in Candida albicans of the TPS2 gene encoding trehalose-6-phosphate phosphatase affects cell integrity and decreases infectivity","volume":"148","author":"Zaragoza","year":"2002","journal-title":"Microbiology"}],"container-title":["Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/mic.0.2006\/003921-0?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T22:49:08Z","timestamp":1628808548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/mic.0.2006\/003921-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,1]]},"references-count":41,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5,1]]}},"URL":"https:\/\/doi.org\/10.1099\/mic.0.2006\/003921-0","relation":{},"ISSN":["1350-0872","1465-2080"],"issn-type":[{"value":"1350-0872","type":"print"},{"value":"1465-2080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,1]]}}}