{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:29:18Z","timestamp":1792801758468,"version":"4.5.0"},"reference-count":109,"publisher":"Microbiology Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,2,1]]},"DOI":"10.1099\/mic.0.26082-0","type":"journal-article","created":{"date-parts":[[2003,3,6]],"date-time":"2003-03-06T15:05:24Z","timestamp":1046963124000},"page":"279-294","source":"Crossref","is-referenced-by-count":941,"title":["Are dental diseases examples of ecological catastrophes?"],"prefix":"10.1099","volume":"149","author":[{"given":"P. D.","family":"Marsh","sequence":"first","affiliation":[{"name":"Research Division, Centre for Applied Microbiology and Research, Salisbury SP4 0JG, and Division of Oral Biology, Leeds Dental Institute, Clarendon Way, Leeds LS2 9LU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","volume-title":"Microbial Ecology","author":"Alexander","year":"1971"},{"key":"R2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/978-1-4612-5868-1_4","article-title":"Microbial interactions on skin","volume-title":"Skin Microbiology: Relevance to Clinical Infection","author":"Aly","year":"1981"},{"key":"R3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1600-0757.1999.tb00158.x","article-title":"Oral ecology and person-to-person transmission of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis","volume":"20","author":"Asikainen","year":"1999","journal-title":"Periodontol"},{"key":"R4","first-page":"170","article-title":"Links between microbial colonization, inflammatory response and tissue destruction","volume-title":"Oral Biology at the Turn of the Century: Misconceptions, Truths, Challenges and Prospects","author":"Birkedal-Hansen","year":"1998"},{"key":"R5","doi-asserted-by":"crossref","first-page":"4012","DOI":"10.1128\/IAI.68.7.4012-4017.2000","article-title":"Identification of ragAB as a temperature-regulated operon of Porphyromonas gingivalis W50 using differential display of randomly primed RNA","volume":"68","author":"Bonass","year":"2000","journal-title":"Infect Immun"},{"key":"R6","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1177\/00220345900690051701","article-title":"Microbiology of root surface caries in humans","volume":"69","author":"Bowden","year":"1990","journal-title":"J Dent Res"},{"key":"R7","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1177\/10454411980090010401","article-title":"Survival of oral bacteria","volume":"9","author":"Bowden","year":"1998","journal-title":"Crit Rev Oral Biol Med"},{"key":"R8","first-page":"233","article-title":"The microflora associated with developing carious lesions of the distal surfaces of the upper first premolars in 13\u201314 year old children","volume-title":"Microbial Aspects of Dental Caries","author":"Bowden","year":"1976"},{"key":"R9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1159\/000261977","article-title":"Effect of sugar alcohols on the composition and metabolism of a mixed culture of oral bacteria grown in a chemostat","volume":"28","author":"Bradshaw","year":"1994","journal-title":"Caries Res"},{"key":"R10","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1159\/000016487","article-title":"Analysis of pH-driven disruption of oral microbial communities in vitro","volume":"32","author":"Bradshaw","year":"1998","journal-title":"Caries Res"},{"key":"R11","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0076-6879(99)10024-7","article-title":"Use of continuous flow techniques in modeling dental plaque biofilms","volume":"310","author":"Bradshaw","year":"1999","journal-title":"Methods Enzymol"},{"key":"R12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1177\/00220345930720010301","article-title":"The effects of triclosan and zinc citrate, alone and in combination, on a community of oral bacteria grown in vitro","volume":"72","author":"Bradshaw","year":"1993","journal-title":"J Dent Res"},{"key":"R13","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1099\/13500872-140-12-3407","article-title":"Metabolic cooperation in oral microbial communities during growth on mucin","volume":"140","author":"Bradshaw","year":"1994","journal-title":"Microbiology"},{"key":"R14","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1099\/13500872-142-3-623","article-title":"Effect of oxygen, inoculum composition and flow rate on development of mixed culture oral biofilms","volume":"142","author":"Bradshaw","year":"1996a","journal-title":"Microbiology"},{"key":"R15","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/j.1365-2672.1996.tb03199.x","article-title":"A modified chemostat system to study the ecology of oral biofilms","volume":"80","author":"Bradshaw","year":"1996b","journal-title":"J Appl Bacteriol"},{"key":"R16","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/j.1472-765X.1997.tb00001.x","article-title":"Oral anaerobes cannot survive oxygen stress without interacting with aerobic\/facultative species as a microbial community","volume":"25","author":"Bradshaw","year":"1997","journal-title":"Lett Appl Microbiol"},{"key":"R17","doi-asserted-by":"crossref","first-page":"4729","DOI":"10.1128\/IAI.66.10.4729-4732.1998","article-title":"Role of Fusobacterium nucleatum and coaggregation in anaerobe survival in planktonic and biofilm oral microbial communities during aeration","volume":"66","author":"Bradshaw","year":"1998","journal-title":"Infect Immun"},{"key":"R18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0167-7012(89)90062-6","article-title":"The use of defined inocula stored in liquid nitrogen for mixed-culture chemostat studies","volume":"9","author":"Bradshaw","year":"1989a","journal-title":"J Microbiol Methods"},{"key":"R19","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1177\/00220345890680090101","article-title":"Effects of carbohydrate pulses and pH on population shifts within oral microbial communities in vitro","volume":"68","author":"Bradshaw","year":"1989b","journal-title":"J Dent Res"},{"key":"R20","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1177\/00220345900690020301","article-title":"Prevention of population shifts in oral microbial communities in vitro by low fluoride concentrations","volume":"69","author":"Bradshaw","year":"1990","journal-title":"J Dent Res"},{"key":"R21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000057864","article-title":"Effects of glucose and fluoride on competition and metabolism within in vitro dental bacterial communities and biofilms","volume":"36","author":"Bradshaw","year":"2002","journal-title":"Caries Res"},{"key":"R22","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1177\/00220345010800091101","article-title":"The predominant aciduric microflora of root-caries lesions","volume":"80","author":"Brailsford","year":"2001","journal-title":"J Dent Res"},{"key":"R23","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1177\/08959374970110011301","article-title":"Physico-chemical interactions in initial microbial adhesion and relevance for biofilm formation","volume":"11","author":"Busscher","year":"1997","journal-title":"Adv Dent Res"},{"key":"R24","series-title":"Society for General Microbiology symposium no. 59","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1017\/CBO9780511754814.003","article-title":"Initial microbial adhesion events: mechanisms and implications","volume-title":"Community Structure and Co-operation in Biofilms","author":"Busscher","year":"2000"},{"key":"R25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2166\/wst.1995.0177","article-title":"Cyanobacterial toxins: occurrence, properties and biological significance","volume":"32","author":"Codd","year":"1995","journal-title":"Water Sci Technol"},{"key":"R26","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev.mi.41.100187.002251","article-title":"Bacterial biofilms in nature and disease","volume":"41","author":"Costerton","year":"1987","journal-title":"Annu Rev Microbiol"},{"key":"R27","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1128\/JB.176.8.2137-2142.1994","article-title":"Biofilms, the customized microniche","volume":"176","author":"Costerton","year":"1994","journal-title":"J Bacteriol"},{"key":"R28","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1146\/annurev.mi.49.100195.003431","article-title":"Microbial biofilms","volume":"49","author":"Costerton","year":"1995","journal-title":"Annu Rev Microbiol"},{"key":"R29","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1600-051X.1991.tb02316.x","article-title":"Zinc citrate\/triclosan: a new anti-plaque system for the control of plaque and the prevention of gingivitis: short-term clinical and mode of action studies","volume":"18","author":"Cummins","year":"1991","journal-title":"J Clin Periodontol"},{"key":"R30","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1177\/10454411010120030101","article-title":"Cysteine proteases of Porphyromonas gingivalis","volume":"12","author":"Curtis","year":"2001","journal-title":"Crit Rev Oral Biol Med"},{"key":"R31","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1600-0757.1997.tb00190.x","article-title":"The microbial challenge in periodontitis","volume":"14","author":"Darveau","year":"1997","journal-title":"Periodontol"},{"key":"R32","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1034\/j.1399-302x.2000.150308.x","article-title":"The diversity of periodontal spirochetes by 16S rRNA analysis","volume":"15","author":"Dewhirst","year":"2000","journal-title":"Oral Microbiol Immunol"},{"key":"R33","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1902\/jop.1997.68.1.18","article-title":"Occurrence of Porphyromonas gingivalis , Bacteroides forsythus and Treponema denticola in periodontally healthy and diseased subjects as determined by an ELISA technique","volume":"68","author":"Di Murro","year":"1997","journal-title":"J Periodontol"},{"key":"R34","first-page":"18","article-title":"The effect of sweeteners on acid production in plaque","volume":"35","author":"Edgar","year":"1985","journal-title":"Int Dent J"},{"key":"R35","volume-title":"Saliva and Dental Health","author":"Edgar","year":"1996"},{"key":"R36","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0003-9969(91)90091-8","article-title":"The pH of gingival crevices and periodontal pockets in children, teenagers and adults","volume":"36","author":"Eggert","year":"1991","journal-title":"Arch Oral Biol"},{"key":"R37","first-page":"270","article-title":"The mouth as a chemostat","volume-title":"Continuous Culture 6: Applications and New Fields","author":"Ellwood","year":"1976"},{"key":"R38","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1128\/IAI.23.2.224-231.1979","article-title":"Effect of growth rate and glucose concentration on the activity of the phosphoenolpyruvate phosphotransferase system in Streptococcus mutans Ingbritt grown in continuous culture","volume":"23","author":"Ellwood","year":"1979","journal-title":"Infect Immun"},{"key":"R39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3109\/10408419509113541","article-title":"Low pH adaptation and the acid tolerance response in Salmonella typhimurium","volume":"21","author":"Foster","year":"1995","journal-title":"Crit Rev Microbiol"},{"key":"R40","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3109\/08910608809140176","article-title":"Enhanced growth of complex communities of dental plaque bacteria in mucin-limited continuous culture","volume":"1","author":"Glenister","year":"1988","journal-title":"Microb Ecol Health Dis"},{"key":"R41","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1177\/00220345940730080501","article-title":"Interdental supragingival plaque \u2013 a natural habitat of Actinobacillus actinomycetemcomitans , Bacteroides forsythus , Campylobacter rectus and Prevotella nigrescens","volume":"73","author":"Gmu\u0308r","year":"1994","journal-title":"J Dent Res"},{"key":"R42","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1902\/jop.1997.68.5.421","article-title":"Bacterial transmission in periodontal diseases: a critical review","volume":"68","author":"Greenstein","year":"1997","journal-title":"J Periodontol"},{"key":"R43","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000260914","article-title":"Studies of the inhibitory action of intense sweeteners on oral microorganisms relating to dental health","volume":"20","author":"Grenby","year":"1986","journal-title":"Caries Res"},{"key":"R44","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0065-2911(08)60147-2","article-title":"Molecular responses of microbes to environmental pH stress","volume":"37","author":"Hall","year":"1995","journal-title":"Adv Microb Physiol"},{"key":"R45","first-page":"94","article-title":"Effects of changing environment on sugar transport and metabolism by oral bacteria","volume-title":"Sugar Transport and Metabolism in Gram-positive Bacteria","author":"Hamilton","year":"1987"},{"key":"R46","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1128\/IAI.26.3.861-869.1979","article-title":"Effect of growth rate and glucose concentration on the biochemical properties of Streptococcus mutans Ingbritt in continuous culture","volume":"26","author":"Hamilton","year":"1979","journal-title":"Infect Immun"},{"key":"R47","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1574-6968.1992.tb05163.x","article-title":"Synergistic degradation of bovine serum albumin by mutans streptococci and other dental plaque bacteria","volume":"90","author":"Homer","year":"1992","journal-title":"FEMS Microbiol Lett"},{"key":"R48","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/10454411970080020601","article-title":"Streptococcal adhesion and colonization","volume":"8","author":"Jenkinson","year":"1997","journal-title":"Crit Rev Oral Biol Med"},{"key":"R49","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1177\/00220345830620101001","article-title":"Plaque pH measurements by different methods on the buccal and approximal surfaces of human teeth after a sucrose rinse","volume":"62","author":"Jensen","year":"1983","journal-title":"J Dent Res"},{"key":"R50","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1099\/13500872-142-3-631","article-title":"Development of a steady-state microbial biofilm community using the constant depth film fermenter","volume":"142","author":"Kinniment","year":"1996a","journal-title":"Microbiology"},{"key":"R51","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1365-2672.1996.tb04488.x","article-title":"The effect of chlorhexidine on defined, mixed culture oral biofilms grown in a novel model system","volume":"81","author":"Kinniment","year":"1996b","journal-title":"J Appl Bacteriol"},{"key":"R52","first-page":"222","article-title":"DNA probe detection of key periodontal pathogens in juveniles","volume":"13","author":"Kisby","year":"1989","journal-title":"J Pedod"},{"key":"R53","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1128\/JB.175.11.3247-3252.1993","article-title":"Adhere today, here tomorrow: oral bacterial adherence","volume":"175","author":"Kolenbrander","year":"1993","journal-title":"J Bacteriol"},{"key":"R54","series-title":"Society for General Microbiology symposium no. 59","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1017\/CBO9780511754814.006","article-title":"Coaggregation and coadhesion in oral biofilms","volume-title":"Community Structure and Co-operation in Biofilms","author":"Kolenbrander","year":"2000"},{"key":"R55","doi-asserted-by":"crossref","first-page":"14547","DOI":"10.1073\/pnas.96.25.14547","article-title":"Bacterial diversity within the human subgingival crevice","volume":"96","author":"Kroes","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R56","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0140-6736(83)90566-4","article-title":"Double-blind study to compare the selection of antibiotic resistance by amoxycillin or cephradine in the commensal flora","author":"Lacey","year":"1983","journal-title":"Lancet ii"},{"key":"R57","first-page":"131","article-title":"Adhesion as an ecological determinant in the oral cavity","volume-title":"Oral Bacterial Ecology: the Molecular Basis","author":"Lamont","year":"2000"},{"key":"R58","first-page":"63","article-title":"Chemotherapy of dental plaque infections","volume":"9","author":"Loesche","year":"1976","journal-title":"Oral Sci Rev"},{"key":"R59","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1128\/MR.50.4.353-380.1986","article-title":"Role of Streptococcus mutans in human dental decay","volume":"50","author":"Loesche","year":"1986","journal-title":"Microbiol Rev"},{"key":"R60","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1139\/m95-133","article-title":"Antimicrobial actions of fluoride for oral bacteria","volume":"41","author":"Marquis","year":"1995a","journal-title":"Can J Microbiol"},{"key":"R61","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/BF01569826","article-title":"Oxygen metabolism, oxidative stress and acid-base physiology of dental plaque biofilms","volume":"15","author":"Marquis","year":"1995b","journal-title":"J Ind Microbiol"},{"key":"R62","first-page":"1567","article-title":"Host defenses and microbial homeostasis: role of microbial interactions","volume":"68","author":"Marsh","year":"1989","journal-title":"J Dent Res"},{"key":"R63","first-page":"515","article-title":"Sugar, fluoride, pH and microbial homeostasis in dental plaque","volume":"87","author":"Marsh","year":"1991","journal-title":"Proc Finn Dent Soc"},{"key":"R64","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1177\/08959374940080022001","article-title":"Microbial ecology of dental plaque and its significance in health and disease","volume":"8","author":"Marsh","year":"1994","journal-title":"Adv Dent Res"},{"key":"R65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jctb.280640102","article-title":"The role of continous culture in modelling the human microflora","volume":"64","author":"Marsh","year":"1995","journal-title":"J Chem Tech Biotech"},{"key":"R66","first-page":"22","article-title":"The control of oral biofilms: new approaches for the future","volume-title":"Oral Biology at the Turn of the Century: Misconceptions, Truths, Challenges and Prospects","author":"Marsh","year":"1998"},{"key":"R67","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0011-8532(22)00816-3","article-title":"Microbiologic aspects of dental plaque and dental caries","volume":"43","author":"Marsh","year":"1999","journal-title":"Dent Clin North Am"},{"key":"R68","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/089106000750051800","article-title":"Role of the oral microflora in health","volume":"12","author":"Marsh","year":"2000a","journal-title":"Microb Ecol Health Dis"},{"key":"R69","first-page":"11","article-title":"Oral ecology and its impact on oral microbial diversity","volume-title":"Oral Bacterial Ecology: the Molecular Basis","author":"Marsh","year":"2000b"},{"key":"R70","series-title":"Society for General Microbiology symposium no. 59","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1017\/CBO9780511754814.010","article-title":"Microbial community interactions in biofilms","volume-title":"Community Structure and Co-operation in Biofilms","author":"Marsh","year":"2000"},{"key":"R71","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1177\/08959374970110010901","article-title":"Physiological approaches to plaque control","volume":"11","author":"Marsh","year":"1997","journal-title":"Adv Dent Res"},{"key":"R72","first-page":"41","article-title":"Dental plaque: community spirit in action","volume-title":"Microbial Pathogenesis: Current and Emerging Issues","author":"Marsh","year":"1998"},{"key":"R73","first-page":"237","article-title":"Microbial community aspects of dental plaque","volume-title":"Dental Plaque Revisited","author":"Marsh","year":"1999"},{"key":"R74","volume-title":"Oral Microbiology","author":"Marsh","year":"1999"},{"key":"R75","first-page":"755","article-title":"The influence of growth rate and nutrient limitation on the microbial composition and biochemical properties of a mixed culture of oral bacteria grown in a chemostat","volume":"129","author":"Marsh","year":"1983a","journal-title":"J Gen Microbiol"},{"key":"R76","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0003-9969(83)90152-8","article-title":"Inhibition by the antimicrobial agent chlorhexidine of acid production and sugar transport in oral streptococcal bacteria","volume":"28","author":"Marsh","year":"1983b","journal-title":"Arch Oral Biol"},{"key":"R77","first-page":"2505","article-title":"Environmental regulation of carbohydrate metabolism by Streptococcus sanguis NCTC 7865 grown in a chemostat","volume":"131","author":"Marsh","year":"1985","journal-title":"J Gen Microbiol"},{"key":"R78","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1177\/00220345890680070301","article-title":"A microbiological study of early caries of approximal surfaces in schoolchildren","volume":"68","author":"Marsh","year":"1989","journal-title":"J Dent Res"},{"key":"R79","first-page":"105","article-title":"Continuous culture studies","volume-title":"Biology of the Species Porphyromonas gingivalis","author":"Marsh","year":"1993"},{"key":"R80","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1099\/00221287-140-4-861","article-title":"The effect of growth rate and haemin on the virulence and proteolytic activity of Porphyromonas gingivalis W50","volume":"140","author":"Marsh","year":"1994","journal-title":"Microbiology"},{"key":"R81","first-page":"A","article-title":"Effect of a redox agent on obligate anaerobes in oral microbial communities","volume":"81","author":"Marsh","year":"2002","journal-title":"J Dent Res"},{"key":"R82","first-page":"1205","article-title":"The effect of lowering the pH on the composition and metabolism of a community of nine oral bacteria grown in a chemostat","volume":"132","author":"McDermid","year":"1986","journal-title":"J Gen Microbiol"},{"key":"R83","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1177\/00220345870660080501","article-title":"A mixed-culture chemostat system to predict the effect of anti-microbial agents on the oral flora: preliminary studies using chlorhexidine","volume":"66","author":"McDermid","year":"1987","journal-title":"J Dent Res"},{"key":"R84","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1128\/IAI.56.5.1096-1100.1988","article-title":"Effect of environmental pH on enzyme activity and growth of Bacteroides gingivalis W50","volume":"56","author":"McDermid","year":"1988","journal-title":"Infect Immun"},{"key":"R85","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1080\/08910600050216183","article-title":"Normal flora: diversity and functions","volume":"12","author":"McFarland","year":"2000","journal-title":"Microb Ecol Health Dis"},{"key":"R86","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1365-2672.1985.tb01788.x","article-title":"The establishment of reproducible, complex communities of oral bacteria in the chemostat using defined inocula","volume":"59","author":"McKee","year":"1985","journal-title":"J Appl Bacteriol"},{"key":"R87","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1128\/IAI.52.2.349-355.1986","article-title":"Effect of haemin on the physiology and virulence of Bacteroides gingivalis W50","volume":"52","author":"McKee","year":"1986","journal-title":"Infect Immun"},{"key":"R88","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1111\/j.1600-0757.1994.tb00019.x","article-title":"The bacteria of periodontal diseases","volume":"5","author":"Moore","year":"1994","journal-title":"Periodontol"},{"key":"R89","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1600-051X.1990.tb01102.x","article-title":"Plaque and chronic inflammatory disease","volume":"17","author":"Newman","year":"1990","journal-title":"J Clin Periodontol"},{"key":"R90","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1600-051X.1995.tb00184.x","article-title":"The effects on chronic periodontitis of a subgingivally-placed redox agent in a slow release device","volume":"22","author":"Ower","year":"1995","journal-title":"J Clin Periodontol"},{"key":"R91","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1128\/JB.183.12.3770-3783.2001","article-title":"Bacterial diversity in human subgingival plaque","volume":"183","author":"Paster","year":"2001","journal-title":"J Bacteriol"},{"key":"R92","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1128\/IAI.67.4.1917-1921.1999","article-title":"Effect of temperature on growth, hemagglutination and protease activity of Porphyromonas gingivalis","volume":"67","author":"Percival","year":"1999","journal-title":"Infect Immun"},{"key":"R93","volume-title":"Micro-organisms Indigenous to Man","author":"Rosebury","year":"1962"},{"key":"R94","first-page":"217","article-title":"Modification of normal flora by antibiotics: effects on individuals and the environment","volume-title":"New Dimensions in Antimicrobial Chemotherapy","author":"Sanders","year":"1984"},{"key":"R95","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1177\/00220345930720020701","article-title":"The association of mutans streptococci and non-mutans streptococci capable of acidogenesis at a low pH with dental caries on enamel and root surfaces","volume":"72","author":"Sansone","year":"1993","journal-title":"J Dent Res"},{"key":"R96","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/10454411940050030201","article-title":"Saliva\u2013bacterium interactions in oral microbial ecology","volume":"5","author":"Scannapieco","year":"1994","journal-title":"Crit Rev Oral Biol Med"},{"key":"R97","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Microbial complexes in subgingival plaque","volume":"25","author":"Socransky","year":"1998","journal-title":"J Clin Peridontol"},{"key":"R98","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1600-0757.1999.tb00165.x","article-title":"Ecological considerations in the treatment of Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis periodontal infections","volume":"20","author":"Socransky","year":"1999","journal-title":"Periodontol"},{"key":"R99","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1574-6968.2001.tb10937.x","article-title":"Protein expression by planktonic and biofilm cells of Streptococcus mutans","volume":"205","author":"Svensater","year":"2001","journal-title":"FEMS Microbiol Lett"},{"key":"R100","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/002203450208100112","article-title":"The microbiota of young children from tooth and tongue samples","volume":"81","author":"Tanner","year":"2002","journal-title":"J Dent Res"},{"key":"R101","volume-title":"Normal Microflora: an Introduction to Microbes Inhabiting the Human Body","author":"Tannock","year":"1995"},{"issue":"suppl 1","key":"R102","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1159\/000049115","article-title":"Consensus statements on fluoride usage and associated research questions","volume":"35","author":"ten Cate","year":"2001","journal-title":"Caries Res"},{"key":"R103","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/BF00393933","article-title":"Enrichment of subgingival microflora on human serum leading to accumulation of Bacteroides species, peptostreptococci and fusobacteria","volume":"53","author":"ter Steeg","year":"1987","journal-title":"Antonie van Leeuwenhoek"},{"key":"R104","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1111\/j.1600-051X.1986.tb01425.x","article-title":"The non-specific theory in microbial etiology of inflammatory periodontal diseases","volume":"13","author":"Theilade","year":"1986","journal-title":"J Clin Periodontol"},{"key":"R105","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1600-0765.1992.tb02080.x","article-title":"Predominant obligate anaerobes in human periodontal pockets","volume":"27","author":"Uematsu","year":"1992","journal-title":"J Periodont Res"},{"key":"R106","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1128\/AEM.65.8.3502-3511.1999","article-title":"Depth penetration and detection of pH gradients in biofilms using two-photon excitation microscopy","volume":"65","author":"Vroom","year":"1999","journal-title":"Appl Environ Microbiol"},{"key":"R107","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1146\/annurev.micro.50.1.513","article-title":"Mechanisms of adhesion by oral bacteria","volume":"50","author":"Whittaker","year":"1996","journal-title":"Annu Rev Microbiol"},{"key":"R108","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1128\/AEM.68.5.2382-2390.2002","article-title":"Analysis of Streptococcus mutans proteins modulated by culture under acidic conditions","volume":"68","author":"Wilkins","year":"2002","journal-title":"Appl Environ Microbiol"},{"key":"R109","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1099\/00222615-19-1-15","article-title":"Effect of repeated high dose prophylaxis with amoxycillin on the resident oral flora of adult volunteers","volume":"19","author":"Woodman","year":"1985","journal-title":"J Med Microbiol"}],"container-title":["Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/mic.0.26082-0?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T02:01:00Z","timestamp":1704765660000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/mic.0.26082-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2,1]]},"references-count":109,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,2,1]]}},"URL":"https:\/\/doi.org\/10.1099\/mic.0.26082-0","relation":{},"ISSN":["1350-0872","1465-2080"],"issn-type":[{"value":"1350-0872","type":"print"},{"value":"1465-2080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,2,1]]}}}