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This suggests that<jats:italic>Pneumocystis<\/jats:italic>organisms do not have a salvage pathway for thymidine, and that inhibitors of<jats:italic>de novo<\/jats:italic>synthesis, such as thymidylate synthase inhibitors, may be effective drugs for treating<jats:italic>Pneumocystis<\/jats:italic>pneumonia.<\/jats:p>","DOI":"10.1099\/mic.0.26890-0","type":"journal-article","created":{"date-parts":[[2004,5,8]],"date-time":"2004-05-08T00:53:04Z","timestamp":1083977584000},"page":"1179-1182","source":"Crossref","is-referenced-by-count":7,"title":["Inability of Pneumocystis organisms to incorporate bromodeoxyuridine suggests the absence of a salvage pathway for thymidine"],"prefix":"10.1099","volume":"150","author":[{"given":"Vibeke H.","family":"Vestereng","sequence":"first","affiliation":[{"name":"Critical Care Medicine Department, Clinical Center, National Institutes of Health, Building 10, Room 7D43, MSC 1662, Bethesda, MD 20892-1662, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A.","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Department, Clinical Center, National Institutes of Health, Building 10, Room 7D43, MSC 1662, Bethesda, MD 20892-1662, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1006\/jmbi.2000.3544","article-title":"The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design","volume":"297","author":"Anderson","year":"2000","journal-title":"J Mol Biol"},{"key":"R2","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1084\/jem.183.3.1229","article-title":"Expression of variants of the major surface glycoprotein of Pneumocystis carinii","volume":"183","author":"Angus","year":"1996","journal-title":"J Exp Med"},{"key":"R3","first-page":"621","article-title":"Thymidylate synthase inhibitors","volume":"26","author":"Danenberg","year":"1999","journal-title":"Semin Oncol"},{"key":"R4","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/BF02389685","article-title":"Bromodeoxyuridine: a diagnostic tool in biology and medicine, part II: oncology, chemotherapy and carcinogenesis","volume":"27","author":"Dolbeare","year":"1995a","journal-title":"Histochem J"},{"key":"R5","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF02389022","article-title":"Bromodeoxyuridine: a diagnostic tool in biology and medicine, part I: historical perspectives, histochemical methods and cell kinetics","volume":"27","author":"Dolbeare","year":"1995b","journal-title":"Histochem J"},{"key":"R6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/BF02331377","article-title":"Bromodeoxyuridine: a diagnostic tool in biology and medicine, part III. 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