{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:03:55Z","timestamp":1791097435811,"version":"4.1.0"},"reference-count":35,"publisher":"Microbiology Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,5,1]]},"abstract":"<jats:p>This study describes the genotyping of <jats:italic>Pneumocystis jirovecii<\/jats:italic> organisms isolated from three groups of patients that developed diverse forms of <jats:italic>P. jirovecii<\/jats:italic> infection; the patients were monitored in the same French hospital. Forty archival specimens from 13 adults with <jats:italic>Pneumocystis<\/jats:italic> pneumonia, eight adults colonized by <jats:italic>P. jirovecii<\/jats:italic> and 19 immunocompetent infants infected with the fungus contemporaneously with a bronchiolitis episode were analysed retrospectively. Genotyping was performed by analysis of sequences of the internal transcribed spacer (ITS)1 and ITS2 regions, and of the dihydropteroate synthase (DHPS) locus. At the ITS regions, a high diversity of genotypes, identical main genotypes (B<jats:sub>1<\/jats:sub>a<jats:sub>3<\/jats:sub> and B<jats:sub>2<\/jats:sub>a<jats:sub>1<\/jats:sub>) and the occurrence of mixed infections (more than one genotype) were observed in the three patient groups. At the DHPS locus, the results indicated the presence of mutants in the two adult groups, as well as in the infant group. Consequently, at these two independent genomic regions, <jats:italic>P. jirovecii<\/jats:italic> isolates from patients who developed different forms of infection and who lived in the same geographical region presented common characteristics. These results suggest that patients infected with <jats:italic>P. jirovecii<\/jats:italic>, whatever the form of infection they present, are part of a common human reservoir for <jats:italic>P. jirovecii<\/jats:italic>.<\/jats:p>","DOI":"10.1099\/mic.0.26919-0","type":"journal-article","created":{"date-parts":[[2004,5,8]],"date-time":"2004-05-08T00:53:04Z","timestamp":1083977584000},"page":"1173-1178","source":"Crossref","is-referenced-by-count":24,"title":["Similar genotypes of Pneumocystis jirovecii in different forms of Pneumocystis infection"],"prefix":"10.1099","volume":"150","author":[{"given":"Anne","family":"Totet","sequence":"first","affiliation":[{"name":"Service de Parasitologie, Mycologie et M\u00e9decine des Voyages, H\u00f4pital Sud, Centre Hospitalier Universitaire, Universit\u00e9 de Picardie Jules Verne, 1 rue Laennec, 80054 Amiens, Paris, 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