{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:41:55Z","timestamp":1759333315015},"reference-count":50,"publisher":"Microbiology Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,4,1]]},"DOI":"10.1099\/mic.0.27820-0","type":"journal-article","created":{"date-parts":[[2005,4,7]],"date-time":"2005-04-07T18:18:56Z","timestamp":1112897936000},"page":"1151-1158","source":"Crossref","is-referenced-by-count":13,"title":["Identification of a conserved Moraxella catarrhalis haemoglobin-utilization protein, MhuA"],"prefix":"10.1099","volume":"151","author":[{"given":"Kristin","family":"Furano","sequence":"first","affiliation":[{"name":"Witebsky Center for Microbial Pathogenesis and Immunology, State University of New York at Buffalo, Buffalo, NY 14214, USA"},{"name":"Department of Microbiology and Immunology, State University of New York at Buffalo, Buffalo, NY 14214, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole R.","family":"Luke","sequence":"additional","affiliation":[{"name":"Witebsky Center for Microbial Pathogenesis and Immunology, State University of New York at Buffalo, Buffalo, NY 14214, USA"},{"name":"Department of Microbiology and Immunology, State University of New York at Buffalo, Buffalo, NY 14214, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy J.","family":"Howlett","sequence":"additional","affiliation":[{"name":"Witebsky Center for Microbial Pathogenesis and Immunology, State University of New York at Buffalo, Buffalo, NY 14214, USA"},{"name":"Department of Microbiology and Immunology, State University of New York at Buffalo, Buffalo, NY 14214, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony A.","family":"Campagnari","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, State University of New York at Buffalo, Buffalo, NY 14214, USA"},{"name":"Witebsky Center for Microbial Pathogenesis and Immunology, State University of New York at Buffalo, Buffalo, NY 14214, USA"},{"name":"Department of Microbiology and Immunology, State University of New York at Buffalo, Buffalo, NY 14214, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1128\/IAI.64.6.2024-2030.1996","article-title":"Expression of the CopB outer membrane protein by Moraxella catarrhalis is regulated by iron and affects iron acquisition from transferrin and lactoferrin","volume":"64","author":"Aebi","year":"1996","journal-title":"Infect Immun"},{"key":"R2","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1128\/IAI.66.7.3113-3119.1998","article-title":"Phenotypic effect of isogenic uspA1 and uspA2 mutations on Moraxella catarrhalis 035E","volume":"66","author":"Aebi","year":"1998","journal-title":"Infect Immun"},{"key":"R3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0264-410X(95)00136-O","article-title":"The meningococcal transferrin-binding proteins 1 and 2 are both surface exposed and generate bactericidal antibodies capable of killing homologous and heterologous strains","volume":"14","author":"Ala'Aldeen","year":"1996","journal-title":"Vaccine"},{"key":"R4","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1128\/IAI.62.7.2984-2990.1994","article-title":"Immune responses in humans and animals to meningococcal transferrin-binding proteins: implications for vaccine design","volume":"62","author":"Ala'Aldeen","year":"1994","journal-title":"Infect Immun"},{"key":"R5","first-page":"271","article-title":"Identification and preliminary characterization of a 75-kDa hemin- and hemoglobin-binding outer membrane protein of Actinobacillus pleuropneumoniae serotype 1","volume":"67","author":"Archambault","year":"2003","journal-title":"Can J Vet Res"},{"key":"R6","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1086\/339174","article-title":"Systemic and mucosal antibody response to Moraxella catarrhalis after exacerbations of chronic obstructive pulmonary disease","volume":"185","author":"Bakri","year":"2002","journal-title":"J Infect Dis"},{"key":"R7","doi-asserted-by":"crossref","first-page":"6063","DOI":"10.1128\/JB.181.19.6063-6072.1999","article-title":"Use of heme-protein complexes by the Yersinia enterocolitica HemR receptor: histidine residues are essential for receptor function","volume":"181","author":"Bracken","year":"1999","journal-title":"J Bacteriol"},{"key":"R8","doi-asserted-by":"crossref","first-page":"4909","DOI":"10.1128\/IAI.62.11.4909-4914.1994","article-title":"Growth of Moraxella catarrhalis with human transferrin and lactoferrin: expression of iron-repressible proteins without siderophore production","volume":"62","author":"Campagnari","year":"1994","journal-title":"Infect Immun"},{"key":"R9","doi-asserted-by":"crossref","first-page":"3920","DOI":"10.1128\/IAI.64.9.3920-3924.1996","article-title":"Outer membrane protein B1, an iron-repressible protein conserved in the outer membrane of Moraxella(Branhamella) catarrhalis, binds human transferrin","volume":"64","author":"Campagnari","year":"1996","journal-title":"Infect Immun"},{"key":"R10","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1128\/IAI.64.6.1900-1905.1996","article-title":"Evaluation of purified UspA from Moraxella catarrhalis as a vaccine in a murine model after active immunization","volume":"64","author":"Chen","year":"1996","journal-title":"Infect Immun"},{"key":"R11","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1128\/jb.177.10.2644-2653.1995","article-title":"A gene cluster involved in the utilization of both free heme and heme\u200a:\u200ahemopexin by Haemophilus influenzae type b","volume":"177","author":"Cope","year":"1995","journal-title":"J Bacteriol"},{"key":"R12","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1128\/IAI.66.9.4511-4516.1998","article-title":"Binding of heme-hemopexin complexes by soluble HxuA protein allows utilization of this complexed heme by Haemophilus influenzae","volume":"66","author":"Cope","year":"1998","journal-title":"Infect Immun"},{"key":"R13","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1365-2958.1994.tb01320.x","article-title":"Iron piracy: acquisition of transferrin-bound iron by bacterial pathogens","volume":"14","author":"Cornelissen","year":"1994","journal-title":"Mol Microbiol"},{"key":"R14","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1046\/j.0818-9641.2002.01141.x","article-title":"Bacterial otitis media: current vaccine development strategies","volume":"81","author":"Cripps","year":"2003","journal-title":"Immunol Cell Biol"},{"key":"R15","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1016\/S0264-410X(00)00272-3","article-title":"Treatment of acute otitis media \u2013 challenges in the era of antibiotic resistance","volume":"19 (Suppl. 1","author":"Dagan","year":"2000","journal-title":"Vaccine"},{"key":"R16","doi-asserted-by":"crossref","first-page":"6456","DOI":"10.1128\/JB.182.22.6456-6462.2000","article-title":"Characterization of a novel outer membrane hemin-binding protein of Porphyromonas gingivalis","volume":"182","author":"Dashper","year":"2000","journal-title":"J Bacteriol"},{"key":"R17","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s004310100754","article-title":"The microbiologic and immunologic basis for recurrent otitis media in children","volume":"160","author":"Faden","year":"2001","journal-title":"Eur J Pediatr"},{"key":"R18","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1128\/IAI.71.4.1843-1848.2003","article-title":"Inactivation of the Moraxella catarrhalis 7169 ferric uptake regulator increases susceptibility to the bactericidal activity of normal human sera","volume":"71","author":"Furano","year":"2003","journal-title":"Infect Immun"},{"key":"R19","doi-asserted-by":"crossref","first-page":"6426","DOI":"10.1128\/IAI.72.11.6426-6432.2004","article-title":"Identification of a hemin utilization protein of Moraxella catarrhalis (HumA)","volume":"72","author":"Furano","year":"2004","journal-title":"Infect Immun"},{"key":"R20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2958.2001.02231.x","article-title":"Emerging strategies in microbial haem capture","volume":"39","author":"Genco","year":"2001","journal-title":"Mol Microbiol"},{"key":"R21","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0966-842X(96)10025-1","article-title":"Bacterial transferrin and lactoferrin receptors","volume":"4","author":"Gray-Owen","year":"1996","journal-title":"Trends Microbiol"},{"key":"R22","doi-asserted-by":"crossref","first-page":"4980","DOI":"10.1128\/IAI.68.9.4980-4985.2000","article-title":"Enhancement of clearance of bacteria from murine lungs by immunization with detoxified lipooligosaccharide from Moraxella catarrhalis conjugated to proteins","volume":"68","author":"Hu","year":"2000","journal-title":"Infect Immun"},{"key":"R23","doi-asserted-by":"crossref","first-page":"5982","DOI":"10.1128\/IAI.70.11.5982-5989.2002","article-title":"Specific immune responses and enhancement of murine pulmonary clearance of Moraxella catarrhalis by intranasal immunization with a detoxified lipooligosaccharide conjugate vaccine","volume":"70","author":"Jiao","year":"2002","journal-title":"Infect Immun"},{"key":"R24","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1574-695X.1999.tb01359.x","article-title":"Analysis of the human Ig isotype response to lactoferrin binding protein A from Neisseria meningitidis","volume":"25","author":"Johnson","year":"1999","journal-title":"FEMS Immunol Med Microbiol"},{"key":"R25","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S1286-4579(00)00314-2","article-title":"Moraxella catarrhalis: a review of an important human mucosal pathogen","volume":"2","author":"Karalus","year":"2000","journal-title":"Microbes Infect"},{"key":"R26","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1128\/IAI.65.7.2970-2974.1997","article-title":"A monoclonal antibody directed against the 97-kilodalton gonococcal hemin-binding protein inhibits hemin utilization by Neisseria gonorrhoeae","volume":"65","author":"Lee","year":"1997","journal-title":"Infect Immun"},{"key":"R27","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1046\/j.1365-2958.1997.2501619.x","article-title":"Molecular characterization of hpuAB, the haemoglobin-haptoglobin-utilization operon of Neisseria meningitidis","volume":"23","author":"Lewis","year":"1997","journal-title":"Mol Microbiol"},{"key":"R28","doi-asserted-by":"crossref","first-page":"6043","DOI":"10.1128\/JB.180.22.6043-6047.1998","article-title":"Transport of intact porphyrin by HpuAB, the hemoglobin-haptoglobin utilization system of Neisseria meningitidis","volume":"180","author":"Lewis","year":"1998","journal-title":"J Bacteriol"},{"key":"R29","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1046\/j.1365-2958.1999.01409.x","article-title":"Phase variation of HpuAB and HmbR, two distinct haemoglobin receptors of Neisseria meningitidis DNM2","volume":"32","author":"Lewis","year":"1999","journal-title":"Mol Microbiol"},{"key":"R30","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.1128\/IAI.67.11.5815-5819.1999","article-title":"Construction and characterization of Moraxella catarrhalis mutants defective in expression of transferrin receptors","volume":"67","author":"Luke","year":"1999","journal-title":"Infect Immun"},{"key":"R31","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1128\/IAI.67.2.681-687.1999","article-title":"Use of an isogenic mutant constructed in Moraxella catarrhalis to identify a protective epitope of outer membrane protein B1 defined by monoclonal antibody 11C6","volume":"67","author":"Luke","year":"1999","journal-title":"Infect Immun"},{"key":"R32","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1128\/IAI.70.2.732-740.2002","article-title":"Specific ligand binding attributable to individual epitopes of gonococcal transferrin binding protein A","volume":"70","author":"Masri","year":"2002","journal-title":"Infect Immun"},{"key":"R33","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1016\/S0264-410X(00)00287-5","article-title":"Vaccines for Moraxella catarrhalis","volume":"19 (Suppl. 1","author":"McMichael","year":"2000","journal-title":"Vaccine"},{"key":"R34","doi-asserted-by":"crossref","first-page":"5899","DOI":"10.1128\/jb.175.18.5899-5906.1993","article-title":"Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells","volume":"175","author":"Me\u0301nard","year":"1993","journal-title":"J Bacteriol"},{"key":"R35","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1128\/IAI.67.6.2729-2739.1999","article-title":"Effect of multiple mutations in the hemoglobin- and hemoglobin-haptoglobin-binding proteins, HgpA, HgpB, and HgpC, of Haemophilus influenzae type b","volume":"67","author":"Morton","year":"1999","journal-title":"Infect Immun"},{"key":"R36","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1128\/MMBR.60.2.267-279.1996","article-title":"Branhamella catarrhalis: epidemiology, surface antigenic structure, and immune response","volume":"60","author":"Murphy","year":"1996","journal-title":"Microbiol Rev"},{"key":"R37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1099\/00221287-146-1-185","article-title":"Genetics and regulation of two distinct haem-uptake systems, phu and has, in Pseudomonas aeruginosa","volume":"146","author":"Ochsner","year":"2000","journal-title":"Microbiology"},{"key":"R38","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3109\/10408419209114559","article-title":"Transferrins and heme-compounds as iron sources for pathogenic bacteria","volume":"18","author":"Otto","year":"1992","journal-title":"Crit Rev Microbiol"},{"key":"R39","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.1128\/IAI.68.9.4938-4947.2000","article-title":"Allelic diversity of the two transferrin binding protein B gene isotypes among a collection of Neisseria meningitidis strains representative of serogroup B disease: implication for the composition of a recombinant TbpB-based vaccine","volume":"68","author":"Rokbi","year":"2000","journal-title":"Infect Immun"},{"key":"R40","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/j.1365-2958.1993.tb01696.x","article-title":"Generation of isogenic K54 capsule-deficient Escherichia coli strains through TnphoA-mediated gene disruption","volume":"9","author":"Russo","year":"1993","journal-title":"Mol Microbiol"},{"key":"R41","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1099\/00222615-29-2-121","article-title":"Identification of the transferrin- and lactoferrin-binding proteins in Haemophilus influenzae","volume":"29","author":"Schryvers","year":"1989","journal-title":"J Med Microbiol"},{"key":"R42","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1046\/j.1365-2958.1999.01411.x","article-title":"Iron acquisition systems in the pathogenic Neisseria","volume":"32","author":"Schryvers","year":"1999","journal-title":"Mol Microbiol"},{"key":"R43","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-1-4757-9068-9_15","article-title":"Bacterial lactoferrin receptors","volume":"443","author":"Schryvers","year":"1998","journal-title":"Adv Exp Med Biol"},{"key":"R44","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1074\/jbc.274.5.2758","article-title":"Hemoglobin endocytosis in Leishmania is mediated through a 46-kDa protein located in the flagellar pocket","volume":"274","author":"Sengupta","year":"1999","journal-title":"J Biol Chem"},{"key":"R45","doi-asserted-by":"crossref","first-page":"4670","DOI":"10.1128\/jb.178.15.4670-4678.1996","article-title":"HmbR outer membrane receptors of pathogenic Neisseria spp.: iron-regulated, hemoglobin-binding proteins with a high level of primary structure conservation","volume":"178","author":"Stojiljkovic","year":"1996","journal-title":"J Bacteriol"},{"key":"R46","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1097\/00006454-198901001-00006","article-title":"The impact of otitis media","volume":"8","author":"Stool","year":"1989","journal-title":"Pediatr Infect Dis J"},{"issue":"(Suppl. 1)","key":"R47","first-page":"S140","article-title":"Antimicrobial prophylaxis for infants at risk for recurrent acute otitis media","volume":"19","author":"Teele","year":"2001","journal-title":"Vaccine"},{"key":"R48","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1128\/CMR.15.1.125-144.2002","article-title":"Moraxella catarrhalis: from emerging to established pathogen","volume":"15","author":"Verduin","year":"2002","journal-title":"Clin Microbiol Rev"},{"key":"R49","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1369-5274(00)00078-3","article-title":"Bacterial heme sources: the role of heme, hemoprotein receptors and hemophores","volume":"3","author":"Wandersman","year":"2000","journal-title":"Curr Opin Microbiol"},{"key":"R50","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1128\/IAI.69.3.1561-1567.2001","article-title":"Recombinant Neisseria meningitidis transferrin binding protein A protects against experimental meningococcal infection","volume":"69","author":"West","year":"2001","journal-title":"Infect Immun"}],"container-title":["Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/mic.0.27820-0?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T18:19:46Z","timestamp":1586197186000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/micro\/10.1099\/mic.0.27820-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,1]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,4,1]]}},"URL":"https:\/\/doi.org\/10.1099\/mic.0.27820-0","relation":{},"ISSN":["1350-0872","1465-2080"],"issn-type":[{"value":"1350-0872","type":"print"},{"value":"1465-2080","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,4,1]]}}}