{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T15:43:15Z","timestamp":1783006995046,"version":"3.54.5"},"reference-count":30,"publisher":"Microbiology Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7,1]]},"abstract":"<jats:p>The ECM33\/SPS2 family of glycosylphosphatidylinositol-anchored proteins plays an important role in maintaining fungal cell wall integrity and virulence. However, the precise molecular role of these proteins is unknown. In this work, <jats:italic>AfuEcm33<\/jats:italic>, the gene encoding the <jats:italic>ECM33<\/jats:italic> homologue in the important pathogenic fungus <jats:italic>Aspergillus fumigatus<\/jats:italic>, has been cloned and its function analysed. It is shown that disruption of <jats:italic>AfuEcm33<\/jats:italic> results in rapid conidial germination, increased cell\u2013cell adhesion, resistance to the antifungal agent caspofungin and increased virulence in an immunocompromised mouse model for disseminated aspergillosis. These results suggest that the protein encoded by <jats:italic>AfuEcm33<\/jats:italic> is involved in key aspects of cell wall morphogenesis and plays an important role in <jats:italic>A. fumigatus<\/jats:italic> virulence.<\/jats:p>","DOI":"10.1099\/mic.0.28936-0","type":"journal-article","created":{"date-parts":[[2006,6,27]],"date-time":"2006-06-27T23:04:33Z","timestamp":1151449473000},"page":"1919-1928","source":"Crossref","is-referenced-by-count":76,"title":["Disruption of the Aspergillus fumigatus ECM33 homologue results in rapid conidial germination, antifungal resistance and hypervirulence"],"prefix":"10.1099","volume":"152","author":[{"given":"Jacob","family":"Romano","sequence":"first","affiliation":[{"name":"Department of Human Microbiology, Sackler School of Medicine, George S. 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