{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T14:00:26Z","timestamp":1761919226137},"reference-count":36,"publisher":"Microbiology Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6,1]]},"abstract":"<jats:p>We determined the complete genome sequence of epidemic keratoconjunctivitis (EKC)-related human adenoviruses (HAdVs). We analysed a total of 12 HAdV strains; three prototype strains and two HAdV-8, three HAdV-19 and three HAdV-37 clinical isolates from EKC patients in Japan, and one novel serotype of HAdV. Genome organization of these serotypes was identical to those of the recently determined HAdV-19 and HAdV-37. The identities of the whole genome were over 99\u200a% among strains from the same serotype, except for HAdV-19p, which is not associated with conjunctivitis, resulting in the formation of a distinct cluster in the phylogenetic analysis. The penton, loop 1 and loop 2 of hexon, early region 3 (E3) and fiber were hypervariable regions between serotypes. Results suggest that the HAdV-19 clinical strain is a recombinant of HAdV-19p-like and HAdV-37-like strains, and that the acquisition of the penton, E3 or fiber may be related to ocular tropism.<\/jats:p>","DOI":"10.1099\/vir.0.009225-0","type":"journal-article","created":{"date-parts":[[2009,5,18]],"date-time":"2009-05-18T18:28:53Z","timestamp":1242671333000},"page":"1471-1476","source":"Crossref","is-referenced-by-count":41,"title":["Analysis of the complete genome sequence of epidemic keratoconjunctivitis-related human adenovirus type 8, 19, 37 and a novel serotype"],"prefix":"10.1099","volume":"90","author":[{"given":"Hisatoshi","family":"Kaneko","sequence":"first","affiliation":[{"name":"Department of Microbiology, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Ishiko","sequence":"additional","affiliation":[{"name":"Host Defense Laboratory, Mitsubishi Chemical Medience Corporation, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Ohguchi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihide","family":"Ariga","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitsugu","family":"Tagawa","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koki","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeaki","family":"Ohno","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Suzutani","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Fukushima Medical University School of Medicine, Fukushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/BF01314287","article-title":"DNA restriction analysis of adenovirus prototype 1 to 41","volume":"91","author":"Adrian","year":"1986","journal-title":"Arch Virol"},{"key":"R2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0923-2516(90)90034-G","article-title":"Restriction site mapping of adenovirus type 8 genome types","volume":"141","author":"Adrian","year":"1990","journal-title":"Res Virol"},{"key":"R3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00004397-200201000-00008","article-title":"A twenty-one year surveillance of adenoviral conjunctivitis in Sapporo, Japan","volume":"42","author":"Aoki","year":"2002","journal-title":"Int Ophthalmol Clin"},{"key":"R4","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.1128\/JCM.02354-07","article-title":"Epidemic keratoconjunctivitis due to the novel hexon-chimeric-intermediate 22,37\/H8 human adenovirus","volume":"46","author":"Aoki","year":"2008","journal-title":"J Clin Microbiol"},{"key":"R5","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1128\/JCM.43.2.726-732.2005","article-title":"Five new genome types of adenovirus type 37 caused epidemic keratoconjunctivitis in Sapporo, Japan, for more than 10 years","volume":"43","author":"Ariga","year":"2005","journal-title":"J Clin Microbiol"},{"key":"R6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1006\/viro.1996.8269","article-title":"Fiber genes of adenoviruses with tropism for the eye and the genital tract","volume":"227","author":"Arnberg","year":"1997","journal-title":"Virology"},{"key":"R7","doi-asserted-by":"crossref","first-page":"7691","DOI":"10.1128\/JVI.74.16.7691-7693.2000","article-title":"Initial interactions of subgenus D adenoviruses with A549 cellular receptors: sialic acid versus \u03b1 v integrins","volume":"74","author":"Arnberg","year":"2000","journal-title":"J Virol"},{"key":"R8","first-page":"227","article-title":"Family Adenoviridae . 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