{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:51:32Z","timestamp":1793839892237,"version":"4.6.1"},"reference-count":119,"publisher":"Microbiology Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,8,1]]},"abstract":"<jats:p>\n                    During the last 30 years, there has been a continued increase in human cases of tick-borne encephalitis (TBE) in Europe, a disease caused by tick-borne encephalitis virus (TBEV). TBEV is endemic in an area ranging from northern China and Japan, through far-eastern Russia to Europe, and is maintained in cycles involving Ixodid ticks (\n                    <jats:italic>Ixodes ricinus<\/jats:italic>\n                    and\n                    <jats:italic>Ixodes persulcatus)<\/jats:italic>\n                    and wild vertebrate hosts. The virus causes a potentially fatal neurological infection, with thousands of cases reported annually throughout Europe. TBE has a significant mortality rate depending upon the strain of virus or may cause long-term neurological\/neuropsychiatric sequelae in people affected. In this review, we comprehensively reviewed TBEV, its epidemiology and pathogenesis, the clinical manifestations of TBE, along with vaccination and prevention. We also discuss the factors which may have influenced an apparent increase in the number of reported human cases each year, despite the availability of effective vaccines.\n                  <\/jats:p>","DOI":"10.1099\/vir.0.011437-0","type":"journal-article","created":{"date-parts":[[2009,7,10]],"date-time":"2009-07-10T14:38:34Z","timestamp":1247236714000},"page":"1781-1794","source":"Crossref","is-referenced-by-count":425,"title":["Tick-borne encephalitis virus \u2013 a review of an emerging zoonosis"],"prefix":"10.1099","volume":"90","author":[{"given":"K. 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form","volume":"69","author":"Allison","year":"1995a","journal-title":"J Virol"},{"key":"R3","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1128\/jvi.69.2.695-700.1995","article-title":"Oligomeric rearrangement of tick-borne encephalitis virus envelope proteins induced by an acidic pH","volume":"69","author":"Allison","year":"1995b","journal-title":"J Virol"},{"key":"R4","first-page":"218","article-title":"Morphological characteristics of the infection of animals with tick-borne encephalitis virus persisting for a long time in cell cultures","volume":"22","author":"Andzhaparidze","year":"1978","journal-title":"Acta Virol"},{"key":"R5","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/S0140-6736(96)90977-0","article-title":"Do specific hyperimmunoglobulins aggravate clinical course of tick-borne encephalitis?","volume":"347","author":"Arras","year":"1996","journal-title":"Lancet"},{"key":"R6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1046\/j.1365-2249.2003.02050.x","article-title":"Changes in immune parameters and their correction in human cases of tick-borne encephalitis","volume":"131","author":"Atrasheuskaya","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"R7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1089\/vbz.2006.6.32","article-title":"Natural tick-borne encephalitis infection among wild small mammals in the southeastern part of western Siberia, Russia","volume":"6","author":"Bakhvalova","year":"2006","journal-title":"Vector Borne Zoonotic Dis"},{"key":"R8","doi-asserted-by":"crossref","first-page":"12828","DOI":"10.1128\/JVI.79.20.12828-12839.2005","article-title":"Inhibition of interferon-stimulated JAK\u2013STAT signalling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist","volume":"79","author":"Best","year":"2005","journal-title":"J Virol"},{"key":"R9","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1146\/annurev.micro.56.012302.160654","article-title":"The molecular biology of West Nile virus: a new invader of the Western hemisphere","volume":"56","author":"Brinton","year":"2002","journal-title":"Annu Rev Microbiol"},{"key":"R10","first-page":"469","article-title":"Antigenic classification and taxonomy of flaviviruses (family Flaviviridae ) emphasizing a universal system for the taxonomy of viruses causing tick-borne encephalitis","volume":"32","author":"Calisher","year":"1988","journal-title":"Acta Virol"},{"key":"R11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-3527(03)59001-7","article-title":"Taxonomy of the virus family Flaviviridae","volume":"59","author":"Calisher","year":"2003","journal-title":"Adv Virus Res"},{"key":"R12","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1099\/vir.0.81783-0","article-title":"Diversity of the population of tick-borne encephalitis virus infecting Ixodes ricinus ticks in an endemic area of central Switzerland","volume":"87","author":"Casati","year":"2006","journal-title":"J Gen Virol"},{"key":"R13","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.mi.44.100190.003245","article-title":"Flavivirus genome organization, expression, and replication","volume":"44","author":"Chambers","year":"1990a","journal-title":"Annu Rev Microbiol"},{"key":"R14","doi-asserted-by":"crossref","first-page":"8898","DOI":"10.1073\/pnas.87.22.8898","article-title":"Evidence that the N-terminal domain of non-structural protein NS3 from yellow fever virus is a serine protease responsible for site-specific cleavages in the viral polyprotein","volume":"87","author":"Chambers","year":"1990b","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R15","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1006\/bbrc.2001.5610","article-title":"Complete coding sequence of the Alkhurma virus, a tick-borne flavivirus causing severe hemorrhagic fever in humans in Saudi Arabia","volume":"287","author":"Charrel","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"R16","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1111\/j.1469-0691.2004.01022.x","article-title":"Tick-borne virus diseases of human interest in Europe","volume":"10","author":"Charrel","year":"2004","journal-title":"Clin Microbiol Infect"},{"key":"R17","doi-asserted-by":"crossref","first-page":"10543","DOI":"10.1128\/JVI.78.19.10543-10555.2004","article-title":"Infectious entry of West Nile virus occurs through a clathrin-mediated endocytic pathway","volume":"78","author":"Chu","year":"2004","journal-title":"J 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Virol"},{"key":"R21","doi-asserted-by":"crossref","first-page":"533","DOI":"10.3201\/eid1003.020734","article-title":"Tick-borne encephalitis in Southern Norway","volume":"10","author":"Cs\u00e1ng\u00f3","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"R22","doi-asserted-by":"crossref","first-page":"323","DOI":"10.14411\/fp.2002.060","article-title":"Potential significance of transovarial transmission in the circulation of tick-borne encephalitis virus","volume":"49","author":"Danielov\u00e1","year":"2002","journal-title":"Folia Parasitol (Praha)"},{"key":"R23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0163-4453(91)92756-U","article-title":"Louping ill in man: a forgotten disease","volume":"23","author":"Davidson","year":"1991","journal-title":"J Infect"},{"key":"R24","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1086\/515195","article-title":"Tick-borne encephalitis","volume":"28","author":"Dumpis","year":"1999","journal-title":"Clin Infect 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Virol"},{"key":"R28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1089\/vbz.2006.0574","article-title":"Seroprevalence of West Nile virus and tick-borne encephalitis virus in southeastern Turkey: first evidence for tick-borne encephalitis infections","volume":"7","author":"Ergunay","year":"2007","journal-title":"Vector Borne Zoonotic Dis"},{"key":"R29","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S1097-2765(01)00206-4","article-title":"Molecular organization of a recombinant subviral particle from tick-borne encephalitis virus","volume":"7","author":"Ferlenghi","year":"2001","journal-title":"Mol Cell"},{"key":"R30","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1083\/jcb.200806081","article-title":"Identification of specific histidines as pH sensors in flavivirus membrane fusion","volume":"183","author":"Fritz","year":"2008","journal-title":"J Cell 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Virol"},{"key":"R46","doi-asserted-by":"crossref","first-page":"7559","DOI":"10.1016\/j.vaccine.2007.08.024","article-title":"Field effectiveness of vaccination against tick-borne encephalitis","volume":"25","author":"Heinz","year":"2007","journal-title":"Vaccine"},{"key":"R47","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1034\/j.1600-0404.2002.01314.x","article-title":"Lymphocyte subset numbers in cerebrospinal fluid: comparison of tick-borne encephalitis and neuroborreliosis","volume":"106","author":"Holub","year":"2002","journal-title":"Acta Neurol Scand"},{"key":"R48","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/S0264-410X(02)00819-8","article-title":"Diagnosis of tick-borne encephalitis","volume":"21","author":"Holzmann","year":"2003","journal-title":"Vaccine"},{"key":"R49","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0264-410X(92)90376-U","article-title":"Molecular epidemiology of tick-borne encephalitis virus: cross-protection between European and Far Eastern subtypes","volume":"10","author":"Holzmann","year":"1992","journal-title":"Vaccine"},{"key":"R50","first-page":"47","article-title":"The nucleotide and deduced amino acid sequence of protein E of HLJ-1 strain of tick-borne encephalitis virus from northeastern China","volume":"13","author":"Hou","year":"1997","journal-title":"Chin J Virol"},{"key":"R51","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.3201\/eid1210.060320","article-title":"Siberian subtype tickborne encephalitis virus, Finland","volume":"12","author":"J\u00e4\u00e4skel\u00e4inen","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"R52","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/nature06536","article-title":"Global trends in emerging infectious diseases","volume":"451","author":"Jones","year":"2008","journal-title":"Nature"},{"key":"R53","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1386-6532(01)00215-3","article-title":"Prevalence of 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encephalitis virus in West Slovakia","volume":"34","author":"Kozuch","year":"1990","journal-title":"Acta Virol"},{"key":"R61","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0042-6822(02)00097-1","article-title":"Role of heparan sulfate for attachment and entry of tick-borne encephalitis virus","volume":"308","author":"Kroschewski","year":"2003","journal-title":"Virology"},{"key":"R62","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/jmedent\/30.1.295","article-title":"Efficient transmission of tick-borne encephalitis virus between cofeeding ticks","volume":"30","author":"Labuda","year":"1993","journal-title":"J Med Entomol"},{"key":"R63","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1006\/viro.1996.0261","article-title":"Importance of localized skin infection in tick-borne encephalitis virus 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II. 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