{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:28:56Z","timestamp":1791332936650,"version":"4.3.1"},"reference-count":29,"publisher":"Microbiology Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6,1]]},"abstract":"<jats:p>Adult T-cell leukaemia\/lymphoma (ATL) is a highly aggressive CD4<jats:sup>+<\/jats:sup>T-cell malignancy caused by human T-cell leukaemia virus type 1. Measles virus (MV) oncolytic therapy has been reported to be efficient in reducing tumour burden in subcutaneous xenograft models of lymphoproliferative disorders such as myeloma, B-cell lymphoma and cutaneous T-cell lymphoma, but its potential to reduce tumour burden in disseminated lymphoproliferative disorders such as ATL remains to be determined. In this study, MV oncolytic therapy was evaluated in the MET-1\/NOD\/SCID xenograft mouse model of ATL. Treatment with the vaccine-related strain MV-NSE led to a significant reduction in tumour burden. In mice with a high tumour burden, therapy with MV-NSE significantly increased survival beyond any other single treatment tested previously using this model. Interestingly, signs of morbidity (cachexia) in mice treated with MV were not directly associated with tumour burden, but were correlated with the secretion of interleukin-6 by MET-1 cells and host cells. The results suggest that MV therapy could be a promising therapy for generalized lymphoproliferative disease.<\/jats:p>","DOI":"10.1099\/vir.0.028910-0","type":"journal-article","created":{"date-parts":[[2011,2,17]],"date-time":"2011-02-17T03:34:44Z","timestamp":1297913684000},"page":"1458-1466","source":"Crossref","is-referenced-by-count":16,"title":["Measles virotherapy in a mouse model of adult T-cell leukaemia\/lymphoma"],"prefix":"10.1099","volume":"92","author":[{"given":"Cecilia","family":"Parrula","sequence":"first","affiliation":[{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad A.","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center, The Arthur James Cancer Hospital and Research Institute, The Ohio State University, Columbus, Ohio, USA"},{"name":"Center for Biostatistics, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bevin","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Lairmore","sequence":"additional","affiliation":[{"name":"Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, USA"},{"name":"Comprehensive Cancer Center, The Arthur James Cancer Hospital and Research Institute, The Ohio State University, Columbus, Ohio, USA"},{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Niewiesk","sequence":"additional","affiliation":[{"name":"Center for Retrovirus Research, The Ohio State University, Columbus, Ohio, USA"},{"name":"Comprehensive Cancer Center, The Arthur James Cancer Hospital and Research Institute, The Ohio State University, Columbus, Ohio, USA"},{"name":"Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1128(199905)19:3<223::AID-MED3>3.0.CO;2-N"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2001.0968"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-04-149658"},{"key":"r4","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/jmr.982","article-title":"High affinity binding between Hsp70 and the C-terminal domain of the measles virus nucleoprotein requires an Hsp40 co-chaperone","volume":"23","author":"Couturier","year":"2009","journal-title":"J Mol Recognit"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.123.6.1889"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.12.3746"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-11-4558"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700529"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.09.039"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2007.01.023"},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1354\/vp.08-VP-0254-N-FL"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.7.2002"},{"key":"r13","first-page":"6977","article-title":"IL-2R\u03b1-directed monoclonal antibodies provide effective therapy in a murine model of adult T-cell leukemia by a mechanism other than blockade of IL-2\/IL-2R\u03b1 interaction","volume":"60","author":"Phillips","year":"2000","journal-title":"Cancer Res"},{"key":"r14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2005.03.020"},{"key":"r15","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1002\/j.1460-2075.1995.tb00266.x","article-title":"Rescue of measles viruses from cloned DNA","volume":"14","author":"Radecke","year":"1995","journal-title":"EMBO J"},{"key":"r16","first-page":"493","article-title":"A simple method of estimating fifty per cent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am J Hyg"},{"key":"r17","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2006.04.016"},{"key":"r18","doi-asserted-by":"crossref","first-page":"180","DOI":"10.4049\/jimmunol.154.1.180","article-title":"Multiple defects in innate and adaptive immunologic function in NOD\/LtSz-scid mice","volume":"154","author":"Shultz","year":"1995","journal-title":"J Immunol"},{"key":"r19","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(03)00076-6"},{"key":"r20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1099\/0022-1317-80-1-101","article-title":"A recombinant measles virus expressing biologically active human interleukin-12","volume":"80","author":"Singh","year":"1999","journal-title":"J Gen Virol"},{"key":"r21","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-008-9151-9"},{"key":"r22","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1099\/0022-1317-79-9-2239","article-title":"Constitutive overexpression of the major inducible 70 kDa heat shock protein mediates large plaque formation by measles virus","volume":"79","author":"Vasconcelos","year":"1998","journal-title":"J Gen Virol"},{"key":"r23","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4049\/jimmunol.133.1.123","article-title":"The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level","volume":"133","author":"Weiss","year":"1984","journal-title":"J Immunol"},{"key":"r24","doi-asserted-by":"publisher","DOI":"10.1126\/science.6980467"},{"key":"r25","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0107"},{"key":"r26","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.17.8737-8746.2002"},{"key":"r27","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0437788100"},{"key":"r28","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3601"},{"key":"r29","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1709"}],"container-title":["Journal of General Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jgv\/10.1099\/vir.0.028910-0?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T05:56:21Z","timestamp":1712210181000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jgv\/10.1099\/vir.0.028910-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,1]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6,1]]}},"URL":"https:\/\/doi.org\/10.1099\/vir.0.028910-0","relation":{},"ISSN":["0022-1317","1465-2099"],"issn-type":[{"value":"0022-1317","type":"print"},{"value":"1465-2099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,1]]}}}