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Secondly, a heparan sulfate (HS) glycochain (of four glycochains in SDC2) is the specific binding site of DENV and seems to be involved in tissue-culture adaptation. Our findings present an entry mechanism that could be implicated for DENV adaptation and HS-mediated DENV infection.<\/jats:p>","DOI":"10.1099\/vir.0.037853-0","type":"journal-article","created":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T04:53:27Z","timestamp":1323924807000},"page":"761-770","source":"Crossref","is-referenced-by-count":43,"title":["Dengue virus strain DEN2 16681 utilizes a specific glycochain of syndecan-2 proteoglycan as a receptor"],"prefix":"10.1099","volume":"93","author":[{"given":"Kenta","family":"Okamoto","sequence":"first","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University and Global COE Program, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitomi","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Virology, Institute of Tropical Medicine, Nagasaki University and Global COE Program, Nagasaki, 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