{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:36:55Z","timestamp":1791196615201,"version":"4.1.0"},"reference-count":29,"publisher":"Microbiology Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,5,1]]},"abstract":"<jats:p>Epstein\u2013Barr virus (EBV) replicates in superficial differentiated cells of oral hairy leukoplakia (OHL). Differentiation of squamous epithelial cells depends on B-lymphocyte-induced maturation protein 1 (Blimp1). Here we show that expression of the EBV immediate-early protein BZLF1 is restricted to Blimp1-positive epithelial cells in OHL. Luciferase assays revealed Blimp1-dependent induction of the BZLF1 promoter Zp in epithelial cell lines. Expression of ZEB1, a negative regulator of Zp, and of Xbp-1, which mediates the Blimp1 effect on Zp in B-cells, was not affected by enforced Blimp1 expression. Moreover, Xbp-1 protein expression was not detected in differentiated epithelial cells of OHL. Thus, Blimp1 induces BZLF1 expression in epithelial cells independently of ZEB1 and Xbp-1. In contrast to epithelial cells of OHL, BZLF1 expression was also observed in Blimp1-negative lymphoid cells in infectious mononucleosis tonsils, suggesting that EBV replication in B-cells may be induced independently of terminal differentiation.<\/jats:p>","DOI":"10.1099\/vir.0.038661-0","type":"journal-article","created":{"date-parts":[[2012,1,26]],"date-time":"2012-01-26T06:15:01Z","timestamp":1327558501000},"page":"1059-1064","source":"Crossref","is-referenced-by-count":22,"title":["Lytic Epstein\u2013Barr virus infection in epithelial cells but not in B-lymphocytes is dependent on Blimp1"],"prefix":"10.1099","volume":"93","author":[{"given":"Maike","family":"Buettner","sequence":"first","affiliation":[{"name":"Institute for Pathology, University Hospital Erlangen, Erlangen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Lang","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Nikolaus Fiebiger Center, 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