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Serum IP-10 was the only analyte that was significantly elevated in HCV resolvers compared with uninfected controls. In individuals who progressed to chronic HCV elevated levels of IP-10 and IL-10 coincided with first significant alanine aminotransferase elevation and remained elevated during the first year of acute HCV infection. In addition to monitoring lack of reduction in viral load, serum levels of IP-10 and IL-10 expression during acute HCV infection may be useful biomarkers to predict the progress to chronic HCV.<\/jats:p>","DOI":"10.1099\/vir.0.041277-0","type":"journal-article","created":{"date-parts":[[2012,4,27]],"date-time":"2012-04-27T00:29:44Z","timestamp":1335486584000},"page":"1673-1679","source":"Crossref","is-referenced-by-count":9,"title":["Detection of host immune responses in acute phase sera of spontaneous resolution versus persistent hepatitis C virus infection"],"prefix":"10.1099","volume":"93","author":[{"given":"Suganya","family":"Selvarajah","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA, USA"},{"name":"Blood Systems Research Institute, San Francisco, CA 94118, 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