{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T22:04:04Z","timestamp":1788991444332,"version":"build-2803163510"},"reference-count":48,"publisher":"Microbiology Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10,1]]},"abstract":"<jats:p>Xi\u2019an, the capital of Shaanxi province, located in north-west China, is one of the major endemic areas for haemorrhagic fever with renal syndrome (HFRS). In this study, the epidemiological data of HFRS in Xi\u2019an from 1959 to 2010, especially in the past ten years (2001\u20132010), were surveyed. The features of hantavirus (HV) host carriers, the molecular characteristics of the HV S gene from hosts and patients, and the genome of the viral isolate were also investigated. Data showed that there might be a ten-year cycle of HFRS in Xi\u2019an. Although the main population group infected over the past ten years was still the 16\u201359-year-old male farmers, the composition of the population and geographical distribution of HFRS cases have changed slowly, accompanied by the development of environmental and socio-economic situations. <jats:italic>Apodemus agrarius<\/jats:italic> remains the dominant host of HV. The HV strains from host rodents and patients in Xi\u2019an belonged to the Hantaan virus (HTNV); no Seoul virus strains were found. Phylogenetic analysis of the small segments of strains taken from hosts and patients, and the whole genome of a viral isolate showed that the virus circulating in Xi\u2019an had high similarity to Guizhou strains. The study also indicated that the vaccine candidate strain A16 isolated during the past century in Xi\u2019an might be a recombinant strain of HTNV and the Amur virus, thus it may not be an optimal vaccine strain.<\/jats:p>","DOI":"10.1099\/vir.0.043364-0","type":"journal-article","created":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T07:43:43Z","timestamp":1343375023000},"page":"2227-2236","source":"Crossref","is-referenced-by-count":29,"title":["Hantaviruses in rodents and humans, Xi\u2019an, PR China"],"prefix":"10.1099","volume":"93","author":[{"given":"Chaofeng","family":"Ma","sequence":"first","affiliation":[{"name":"Xi\u2019an Centers for Disease Control and Prevention, Xi\u2019an, Shaanxi, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengbo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Immunology and Pathogenic Biology, Key Laboratory of Environment and Genes Related to Diseases, Chinese Ministry of Education, School of Medicine, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Nawaz","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Veterinary Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqing","family":"Zuo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiezhi","family":"Jin","sequence":"additional","affiliation":[{"name":"Shaanxi Animal Research Institute, Xi\u2019an, Shaanxi, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinsong","family":"Li","sequence":"additional","affiliation":[{"name":"Xi\u2019an Centers for Disease Control and Prevention, Xi\u2019an, Shaanxi, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengxin","family":"Li","sequence":"additional","affiliation":[{"name":"Xi\u2019an Centers for Disease Control and Prevention, Xi\u2019an, Shaanxi, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiru","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Immunology and Pathogenic Biology, Key Laboratory of Environment and Genes Related to Diseases, Chinese Ministry of Education, School of Medicine, Xi\u2019an Jiaotong University, Xi\u2019an, Shaanxi, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"r1","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1099\/0022-1317-81-7-1747","article-title":"Genetic analysis of wild-type Dobrava hantavirus in Slovenia: co-existence of two distinct genetic lineages within the same natural focus","volume":"81","author":"Avsic-Zupanc","year":"2000","journal-title":"J Gen Virol"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20538"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1126\/science.4048949"},{"key":"r4","first-page":"88","article-title":"Hemorrhagic fever with renal syndrome in Finland: ecology and virology of nephropathia epidemica","volume":"36","author":"Brummer-Korvenkontio","year":"1982","journal-title":"Scand J Infect Dis Suppl"},{"key":"r5","volume-title":"Hemorrhagic Fever with Renal Syndrome Studies on the Surveillance and Application of Vaccine","author":"Chen","year":"2001"},{"key":"r6","first-page":"857","article-title":"Epidemiologic surveillance on the hemorrhagic fever with renal syndrome in China","volume":"106","author":"Chen","year":"1993","journal-title":"Chin Med J (Engl)"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(03)00827-2"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00752-06"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000172"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.3201\/eid1408.080221"},{"key":"r11","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1995.0071"},{"key":"r12","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-56753-7_5"},{"key":"r13","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20957"},{"key":"r14","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00062-09"},{"key":"r15","first-page":"46","article-title":"[A preliminary genetic reassortment between Hantaan virus and Seoul virus strains]","volume":"23","author":"Kang","year":"2002","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"r16","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(98)00141-5"},{"key":"r17","doi-asserted-by":"publisher","DOI":"10.2174\/156652405774962317"},{"key":"r18","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.1.804-809.2003"},{"key":"r19","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/146.5.645"},{"key":"r20","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1995.1020"},{"key":"r21","first-page":"981","article-title":"[Complete genome sequence of 84FLi, a Hantaan virus strain isolated from the liver of fetus aborted by a pregnant women with hemmorrhagic fever with renal syndrome]","volume":"82","author":"Li","year":"2002","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"r22","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1099\/0022-1317-49-7-587","article-title":"Hantaviruses","volume":"49","author":"McCaughey","year":"2000","journal-title":"J Med Microbiol"},{"key":"r23","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.05.018"},{"key":"r24","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1099\/0022-1317-80-2-371","article-title":"Isolation and characterization of Dobrava hantavirus carried by the striped field mouse (Apodemus agrarius) in Estonia","volume":"80","author":"Nemirov","year":"1999","journal-title":"J Gen Virol"},{"key":"r25","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.16.10561-10570.2005"},{"key":"r26","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-56753-7_4"},{"key":"r27","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.07.012"},{"key":"r28","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1997.8990"},{"key":"r29","doi-asserted-by":"crossref","first-page":"8196","DOI":"10.1128\/JVI.73.10.8196-8200.1999","article-title":"Genetic reassortment of Rift Valley fever virus in nature","volume":"73","author":"Sall","year":"1999","journal-title":"J Virol"},{"key":"r30","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02573-06"},{"key":"r31","doi-asserted-by":"publisher","DOI":"10.3201\/eid0302.970202"},{"key":"r32","first-page":"4","article-title":"Study on diversity and distribution of rodents in Shaanxi Province","volume":"14","author":"She","year":"2003","journal-title":"China J Vector Biol & Control"},{"key":"r33","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.43.10.1327"},{"key":"r34","first-page":"472","article-title":"Epidemiological progresses of hemorrhagic fever with renal syndrome in China","volume":"112","author":"Song","year":"1999","journal-title":"Chin Med J (Engl)"},{"key":"r35","first-page":"578","article-title":"[Genetics subtypes and distribution of Seoul virus in Henan]","volume":"26","author":"Sun","year":"2005","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"r36","doi-asserted-by":"publisher","DOI":"10.3201\/eid0907.020587"},{"key":"r37","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msr121"},{"key":"r38","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-9-2255"},{"key":"r39","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009769"},{"key":"r40","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2000.0630"},{"key":"r48","doi-asserted-by":"publisher","DOI":"10.1006\/viro.2000.0630"},{"key":"r41","first-page":"315\u2013320","article-title":"Molecular characteristics of the seed virus of HFRS candidate vaccine A16 strain","volume":"16","author":"Yao","year":"2001","journal-title":"Virol Sin"},{"key":"r42","doi-asserted-by":"crossref","first-page":"912","DOI":"10.3201\/eid0705.017530","article-title":"A newly discovered variant of a hantavirus in Apodemus peninsulae, far Eastern Russia","volume":"7","author":"Yashina","year":"2001","journal-title":"Emerg Infect Dis"},{"key":"r43","first-page":"466","article-title":"[The epidemic characteristics and preventive measures of hemorrhagic fever with syndromes in China]","volume":"25","author":"Zhang","year":"2004","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"r44","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.82534-0"},{"key":"r45","doi-asserted-by":"publisher","DOI":"10.3201\/eid1506.081126"},{"key":"r46","doi-asserted-by":"publisher","DOI":"10.3201\/eid1608.090470"},{"key":"r47","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21149"}],"container-title":["Journal of General Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jgv\/10.1099\/vir.0.043364-0?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T23:36:38Z","timestamp":1603755398000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jgv\/10.1099\/vir.0.043364-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,1]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10,1]]}},"URL":"https:\/\/doi.org\/10.1099\/vir.0.043364-0","relation":{},"ISSN":["0022-1317","1465-2099"],"issn-type":[{"value":"0022-1317","type":"print"},{"value":"1465-2099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,10,1]]}}}