{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:58:03Z","timestamp":1791655083432,"version":"4.3.4"},"reference-count":26,"publisher":"Microbiology Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12,1]]},"abstract":"<jats:p>Hantaan virus (HTNV), a member of the family<jats:italic>Bunyaviridae<\/jats:italic>, is a major agent causing haemorrhagic fever with renal syndrome, a high-mortality-rate disease threatening approximately 150\u200a000 people around the world yearly. The 3D8 mAb displays a neutralizing activity to HTNV infection. In this study, the B-cell epitopes of HTNV glycoproteins (GPs) were finely mapped by peptide scanning. A new B-cell epitope<jats:sup>882<\/jats:sup>GFLCPEFPGSFRKKC<jats:sup>896<\/jats:sup>of HTNV, which locates on Gc, has been screened out from a set of 15-mer synthesized peptides covering the full-length of HTNV-GPs. It has been shown by the alanine-scanning technique that<jats:sup>885<\/jats:sup>C,<jats:sup>893<\/jats:sup>R,<jats:sup>894<\/jats:sup>K,<jats:sup>895<\/jats:sup>K and<jats:sup>896<\/jats:sup>C are the key amino acids of the binding sites of the GPs. The implications of identifying a novel B-cell epitope for hantavirus immunology and vaccinology are discussed.<\/jats:p>","DOI":"10.1099\/vir.0.045302-0","type":"journal-article","created":{"date-parts":[[2012,8,30]],"date-time":"2012-08-30T06:04:19Z","timestamp":1346306659000},"page":"2595-2600","source":"Crossref","is-referenced-by-count":16,"title":["Identification of a novel B-cell epitope of Hantaan virus glycoprotein recognized by neutralizing 3D8 monoclonal antibody"],"prefix":"10.1099","volume":"93","author":[{"given":"Guolin","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Immunology, the Fourth Military Medical University, 17 Changle West Road, Xi\u2019an, Shaanxi 710032, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Immunology, the Fourth Military Medical University, 17 Changle West Road, Xi\u2019an, Shaanxi 710032, PR 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