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C57BL\/6 mice treated with 1MT and infected with A\/HKx31 influenza virus had increased numbers of activated and functional CD4<jats:sup>+<\/jats:sup>T-cells, influenza-specific CD8<jats:sup>+<\/jats:sup>T-cells and effector memory cells in the lung. Inhibition of IDO increased the Th1 response in CD4<jats:sup>+<\/jats:sup>T-cells as well as enhanced the Th17 response. These studies show that inhibition of IDO engenders a more robust T-cell response to influenza virus, and suggests an approach for enhancing the immune response to influenza vaccination by facilitating increased influenza-specific T-cell response.<\/jats:p>","DOI":"10.1099\/vir.0.053124-0","type":"journal-article","created":{"date-parts":[[2013,4,12]],"date-time":"2013-04-12T02:11:28Z","timestamp":1365732688000},"page":"1451-1461","source":"Crossref","is-referenced-by-count":57,"title":["Inhibition of indoleamine 2,3-dioxygenase enhances the T-cell response to influenza virus infection"],"prefix":"10.1099","volume":"94","author":[{"given":"Julie M.","family":"Fox","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo K.","family":"Sage","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Huang","sequence":"additional","affiliation":[{"name":"Immunotherapy Center and Department of Medicine, Georgia Regents University, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Barber","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, University of Georgia, Athens, GA 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly D.","family":"Klonowski","sequence":"additional","affiliation":[{"name":"Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L.","family":"Mellor","sequence":"additional","affiliation":[{"name":"Immunotherapy Center and Department of Medicine, Georgia Regents University, Augusta, GA 30912, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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