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However, little is known about the interactions between this virus and other STAT signalling cascades. Herein, we showed that hMPV can attenuate the IL-6-mediated JAK\/STAT3 signalling cascade in lung epithelial cells. HMPV inhibited a key event in this pathway by impeding the phosphorylation and nuclear translocation of STAT3 in A549 cells and in primary normal human bronchial epithelial cells. Further studies established that hMPV interrupted the IL-6-induced JAK\/STAT pathway early in the signal transduction pathway by blocking the phosphorylation of JAK2. By antagonizing the IL-6-mediated JAK\/STAT3 pathway, hMPV perturbed the expression of IL-6-inducible genes important for apoptosis, cell differentiation and growth. Infection with hMPV also differentially regulated the effects of IL-6 on apoptosis. Thus, hMPV regulation of these genes could usurp the protective roles of IL-6, and these data provide insight into an important element of viral pathogenesis.<\/jats:p>","DOI":"10.1099\/vir.0.055632-0","type":"journal-article","created":{"date-parts":[[2013,10,11]],"date-time":"2013-10-11T14:56:23Z","timestamp":1381503383000},"page":"26-37","source":"Crossref","is-referenced-by-count":27,"title":["Human metapneumovirus inhibits the IL-6-induced JAK\/STAT3 signalling cascade in airway epithelium"],"prefix":"10.1099","volume":"95","author":[{"given":"Dana N.","family":"Mitzel","sequence":"first","affiliation":[{"name":"Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, NM, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Jaramillo","sequence":"additional","affiliation":[{"name":"Infectious Diseases Program, Lovelace Respiratory Research Institute, Albuquerque, NM, 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