{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:43:46Z","timestamp":1793321026074,"version":"4.5.0"},"reference-count":61,"publisher":"Microbiology Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:p>Crimean\u2013Congo haemorrhagic fever virus (CCHFV) is a tick-borne virus with high pathogenicity to humans. CCHFV contains a three-segment [small (S), medium (M) and large (L)] genome and is prone to reassortment. Investigation of identified reassortment events can yield insight into the evolutionary history of the virus, while migration events reflect its geographical dissemination. While many studies have already considered these issues, they have investigated small numbers of isolates and lack statistical support for their findings. Here, we consider a larger set of 30 full genomes to investigate reassortment using recombination methods, as well as two sets of partial S segments comprising 393 isolates, reflecting a broader geographical range, to investigate migration events. Phylogenetic analysis revealed that the S segment showed strong geographical subdivision, but this was less apparent in the M and L segments. A total of 16 reassortment events with 22 isolates were identified with strong statistical support. Migration analysis on the partial S segments identified both long- and short-range migration events that spanned the entire geographical region in which the CCHFV has been isolated, reflecting the complex processes associated with the dissemination of the virus.<\/jats:p>","DOI":"10.1099\/vir.0.056374-0","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T02:34:09Z","timestamp":1376361249000},"page":"2536-2548","source":"Crossref","is-referenced-by-count":39,"title":["Reassortment and migration analysis of Crimean\u2013Congo haemorrhagic fever virus"],"prefix":"10.1099","volume":"94","author":[{"given":"Zhaorui","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Virology and China Center for Virus Culture Collection, Chinese Academy of Sciences, Wuhan 430071, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Deng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology and China Center for Virus Culture Collection, Chinese Academy of Sciences, Wuhan 430071, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Han","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology and China Center for Virus Culture Collection, Chinese Academy of Sciences, Wuhan 430071, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hualin","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology and China Center for Virus Culture Collection, Chinese Academy of Sciences, Wuhan 430071, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surong","family":"Sun","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumuqi, Xinjiang 830046, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, 4 Jianquan First Street, Urumuqi, Xinjiang 830046, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology and China Center for Virus Culture Collection, Chinese Academy of Sciences, Wuhan 430071, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Rayner","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Virology and China Center for Virus Culture Collection, Chinese Academy of Sciences, Wuhan 430071, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"r1","first-page":"175","article-title":"Crimean-Congo hemorrhagic fever virus encodes an NSM protein","volume":"77","author":"Altamura","year":"2007","journal-title":"Am J Trop Med Hyg"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2009.06.018"},{"key":"r3","article-title":"Crimean-Congo Hemorrhagic Fever Virus: interferon-induced antiviral mechanisms and immune evasion strategies. 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