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To understand the mechanism, we prepared GPCMV strains defective in each of GP129, GP131 and GP133, and found that they were all essential for the infection of peritoneal, splenic and PBMC-derived macrophages\/monocytes, and for expression of immediate-early antigens in the macrophages\/monocytes, although they were dispensable for infection of fibroblasts. Monocyte\/macrophage tropism could be one of the important determinants for viral dissemination <jats:italic>in vivo<\/jats:italic>.<\/jats:p>","DOI":"10.1099\/vir.0.064527-0","type":"journal-article","created":{"date-parts":[[2014,3,22]],"date-time":"2014-03-22T03:03:02Z","timestamp":1395457382000},"page":"1376-1382","source":"Crossref","is-referenced-by-count":33,"title":["Guinea pig cytomegalovirus GP129\/131\/133, homologues of human cytomegalovirus UL128\/130\/131A, are necessary for infection of monocytes and macrophages"],"prefix":"10.1099","volume":"95","author":[{"given":"Souichi","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saki","family":"Fukuchi","sequence":"additional","affiliation":[{"name":"Department of Virology I, National Institute of Infectious Diseases, Tokyo, 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