{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:43:44Z","timestamp":1790768624537,"version":"4.1.0"},"reference-count":23,"publisher":"Microbiology Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,1]]},"abstract":"<jats:p>Bokeloh bat lyssavirus (BBLV), a novel lyssavirus, was isolated from a Natterer\u2019s bat (<jats:italic>Myotis nattererii<\/jats:italic>), a chiropteran species with a widespread and abundant distribution across Europe. As a novel lyssavirus, the risks of BBLV to animal and human health are unknown and as such characterization both <jats:italic>in vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> was required to assess pathogenicity and vaccine protection. Full genome sequence analysis and antigenic cartography demonstrated that the German BBLV isolates are most closely related to European bat lyssavirus type 2 (EBLV-2) and Khujand virus and can be characterized within phylogroup I. <jats:italic>In vivo<\/jats:italic> characterization demonstrated that BBLV was pathogenic in mice when inoculated peripherally causing clinical signs typical for rabies encephalitis, with higher pathogenicity observed in juvenile mice. A limited vaccination-challenge experiment in mice was conducted and suggested that current vaccines would afford some protection against BBLV although further studies are warranted to determine a serological cut-off for protection.<\/jats:p>","DOI":"10.1099\/vir.0.065953-0","type":"journal-article","created":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T08:30:10Z","timestamp":1400142610000},"page":"1647-1653","source":"Crossref","is-referenced-by-count":34,"title":["Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus"],"prefix":"10.1099","volume":"95","author":[{"given":"Tobias","family":"Nolden","sequence":"first","affiliation":[{"name":"Friedrich-Loeffler-Institut (FLI), Federal Research Institute for Animal Health, Institute of Molecular Virology and Cell Biology, WHO Collaborating Centre for Rabies Surveillance and Research, S\u00fcdufer 10, D-17493 Greifswald \u2013 Insel Riems, 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