{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T20:06:01Z","timestamp":1767902761983,"version":"3.49.0"},"reference-count":55,"publisher":"Microbiology Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,8,1]]},"abstract":"<jats:p>The genus<jats:italic>Macavirus<\/jats:italic>of the subfamily<jats:italic>Gammaherpesvirinae<\/jats:italic>includes viruses that infect lymphoid cells of domestic and wild ruminants and swine, causing asymptomatic latent infections in reservoir hosts. Here, we describe the genome of bovine herpesvirus 6 (BoHV-6), a macavirus ubiquitous in healthy cattle populations. The BoHV-6 genome exhibited architecture conserved in macaviruses, including a repetitive H-DNA region and unique 141 kbp L-DNA region predicted to encode 77 genes. BoHV-6 encoded, in variable genomic regions, a novel complement of genes relative to other characterized macaviruses, probably contributing to distinctive aspects of BoHV-6 infection biology and host range. Most notably, BoHV-6 encoded the first herpesviral protein (Bov2.b2) similar to cellular ornithine decarboxylase, an enzyme that catalyses the first and rate-limiting step in the biosynthesis of polyamines. Bov2.b2 conceivably mediates a novel mechanism by which BoHV-6 promotes cell-cycle-dependent viral replication.<\/jats:p>","DOI":"10.1099\/vir.0.066951-0","type":"journal-article","created":{"date-parts":[[2014,5,17]],"date-time":"2014-05-17T06:17:53Z","timestamp":1400307473000},"page":"1790-1798","source":"Crossref","is-referenced-by-count":16,"title":["Novel gammaherpesvirus functions encoded by bovine herpesvirus 6 (bovine lymphotropic virus)"],"prefix":"10.1099","volume":"95","author":[{"given":"J.","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Pathobiology, College of Veterinary Medicine, University of Illinois, Urbana, IL, USA"},{"name":"Laboratory of Animal Infectious Disease and Microarray\/Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Animal Veterinary Medicine, Sichuan Agricultural University, Yaan, Sichuan 625014, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Delhon","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine & Biomedical Sciences and Nebraska Center for Virology, University of Nebraska, Lincoln, NE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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