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Only a single vaccine exists for the HHVs and researchers have been unable to develop treatments to cure the persistent infections associated with HHVs. A major hindrance to HHV research has been the lack of suitable animal models, with the notable exception of the herpes simplex viruses. One promising area for HHV research is the use of humanized mouse models, in which human cells or tissues are transplanted into immunodeficient mice. Current humanized mouse models mostly transplant human haematopoietic stem cells (HSCs), resulting in the production of a variety of human immune cells. Although all HHVs are thought to infect human immune cells, the beta- and gammaherpesviruses extensively infect and establish latency in these cells. Thus, mice humanized with HSCs hold great promise to study these herpesviruses. In this review, we provide a historical perspective on the use of both older and newer humanized mouse models to study HHV infections. The focus is on current developments in using humanized mice to study mechanisms of HHV-induced pathogenesis, human immune responses to HHVs and effectiveness of antiviral drugs.<\/jats:p>","DOI":"10.1099\/vir.0.067793-0","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T06:55:52Z","timestamp":1406098552000},"page":"2106-2117","source":"Crossref","is-referenced-by-count":9,"title":["Modelling of human herpesvirus infections in humanized mice"],"prefix":"10.1099","volume":"95","author":[{"given":"Bradford K.","family":"Berges","sequence":"first","affiliation":[{"name":"Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Tanner","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"345","reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-6143.2012.04018.x"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-012-1299-6"},{"key":"r3","first-page":"777","article-title":"Human herpes virus-6 infection in marrow graft recipients: role in pathogenesis of graft-versus-host disease. 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