{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:49:10Z","timestamp":1792622950520,"version":"4.5.0"},"reference-count":43,"publisher":"Microbiology Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"abstract":"<jats:p>The family <jats:italic>Hepeviridae<\/jats:italic> consists of positive-stranded RNA viruses that infect a wide range of mammalian species, as well as chickens and trout. A subset of these viruses infects humans and can cause a self-limiting acute hepatitis that may become chronic in immunosuppressed individuals. Current published descriptions of the taxonomical divisions within the family <jats:italic>Hepeviridae<\/jats:italic> are contradictory in relation to the assignment of species and genotypes. Through analysis of existing sequence information, we propose a taxonomic scheme in which the family is divided into the genera <jats:italic>Orthohepevirus<\/jats:italic> (all mammalian and avian hepatitis E virus (HEV) isolates) and <jats:italic>Piscihepevirus<\/jats:italic> (cutthroat trout virus). Species within the genus <jats:italic>Orthohepevirus<\/jats:italic> are designated <jats:italic>Orthohepevirus<\/jats:italic> A (isolates from human, pig, wild boar, deer, mongoose, rabbit and camel), <jats:italic>Orthohepevirus<\/jats:italic> B (isolates from chicken), <jats:italic>Orthohepevirus<\/jats:italic> C (isolates from rat, greater bandicoot, Asian musk shrew, ferret and mink) and <jats:italic>Orthohepevirus<\/jats:italic> D (isolates from bat). Proposals are also made for the designation of genotypes within the human and rat HEVs. This hierarchical system is congruent with hepevirus phylogeny, and the three classification levels (genus, species and genotype) are consistent with, and reflect discontinuities in the ranges of pairwise distances between amino acid sequences. Adoption of this system would include the avoidance of host names in taxonomic identifiers and provide a logical framework for the assignment of novel variants.<\/jats:p>","DOI":"10.1099\/vir.0.068429-0","type":"journal-article","created":{"date-parts":[[2014,7,3]],"date-time":"2014-07-03T03:51:46Z","timestamp":1404359506000},"page":"2223-2232","source":"Crossref","is-referenced-by-count":587,"title":["Consensus proposals for classification of the family Hepeviridae"],"prefix":"10.1099","volume":"95","author":[{"given":"Donald B.","family":"Smith","sequence":"first","affiliation":[{"name":"University of Edinburgh, Centre for Immunity, Infection and Evolution, Edinburgh, Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Simmonds","sequence":"additional","affiliation":[{"name":"University of Edinburgh, Centre for Immunity, Infection and Evolution, Edinburgh, Scotland, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"members of the International Committee on the Taxonomy of Viruses  Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahid","family":"Jameel","sequence":"additional","affiliation":[{"name":"Wellcome Trust\/DBT India Alliance, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne U.","family":"Emerson","sequence":"additional","affiliation":[{"name":"Special Volunteer, Retired Head Molecular Hepatitis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim J.","family":"Harrison","sequence":"additional","affiliation":[{"name":"University College of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Jin","family":"Meng","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Tochigi-ken, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim H. 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