{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:10:00Z","timestamp":1793502600364,"version":"4.5.0"},"reference-count":56,"publisher":"Microbiology Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,1,1]]},"DOI":"10.1099\/vir.0.19565-0","type":"journal-article","created":{"date-parts":[[2004,1,12]],"date-time":"2004-01-12T23:02:57Z","timestamp":1073948577000},"page":"105-117","source":"Crossref","is-referenced-by-count":349,"title":["Poxvirus genomes: a phylogenetic analysis"],"prefix":"10.1099","volume":"85","author":[{"given":"Caroline","family":"Gubser","sequence":"first","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Hu\u00e9","sequence":"additional","affiliation":[{"name":"Viral Genomics and Bioinformatics Group, Department of Virology, and Department of Immunology & Molecular Pathology, University College London, 46 Cleveland Street, London W1T 4JF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kellam","sequence":"additional","affiliation":[{"name":"Viral Genomics and Bioinformatics Group, Department of Virology, and Department of Immunology & Molecular Pathology, University College London, 46 Cleveland Street, London W1T 4JF, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Virology, Faculty of Medicine, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"345","reference":[{"key":"R1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1128\/JVI.73.1.533-552.1999","article-title":"The genome of Melanoplus sanguinipes entomopoxvirus","volume":"73","author":"Afonso","year":"1999","journal-title":"J Virol"},{"key":"R2","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1128\/JVI.74.8.3815-3831.2000","article-title":"The genome of fowlpox virus","volume":"74","author":"Afonso","year":"2000","journal-title":"J Virol"},{"key":"R3","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1128\/JVI.76.2.783-790.2002","article-title":"The genome of swinepox virus","volume":"76","author":"Afonso","year":"2002a","journal-title":"J Virol"},{"key":"R4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/viro.2001.1343","article-title":"The genome of camelpox virus","volume":"295","author":"Afonso","year":"2002b","journal-title":"Virology"},{"key":"R5","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1099\/0022-1317-73-11-2887","article-title":"Nucleotide sequence of 21\u00b78\u2005kbp of variola major virus strain Harvey and comparison with vaccinia virus","volume":"73","author":"Aguado","year":"1992","journal-title":"J Gen Virol"},{"key":"R6","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1006\/viro.1998.9123","article-title":"The complete genomic sequence of the modified vaccinia Ankara strain: comparison with other orthopoxviruses","volume":"244","author":"Antoine","year":"1998","journal-title":"Virology"},{"key":"R7","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/0042-6822(92)90256-O","article-title":"Vaccinia virus gene B1R encodes a 34-kDa serine\/threonine protein kinase that localizes in cytoplasmic factories and is packaged into virions","volume":"191","author":"Banham","year":"1992","journal-title":"Virology"},{"key":"R8","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1099\/0022-1317-83-8-1965","article-title":"The vaccinia virus N1L protein is an intracellular homodimer that promotes virulence","volume":"83","author":"Bartlett","year":"2002","journal-title":"J Gen Virol"},{"key":"R9","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1006\/viro.2000.0449","article-title":"Complete genomic sequence of the Amsacta moorei entomopoxvirus: analysis and comparison with other poxviruses","volume":"274","author":"Bawden","year":"2000","journal-title":"Virology"},{"key":"R10","volume-title":"Jenner's Smallpox Vaccine","author":"Baxby","year":"1981"},{"key":"R11","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1006\/viro.1999.0001","article-title":"The complete DNA sequence of myxoma virus","volume":"264","author":"Cameron","year":"1999","journal-title":"Virology"},{"key":"R12","doi-asserted-by":"crossref","first-page":"10881","DOI":"10.1093\/nar\/16.22.10881","article-title":"Multiple sequence alignment with hierarchical clustering","volume":"16","author":"Corpet","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"R13","first-page":"158","article-title":"Immunological relationship of the virus of spontaneous cowpox to vaccinia virus","volume":"20","author":"Downie","year":"1939a","journal-title":"Br J Exp Pathol"},{"key":"R14","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/path.1700480212","article-title":"A study of the lesions produced experimentally by cowpox virus","volume":"48","author":"Downie","year":"1939b","journal-title":"J Pathol Bacteriol"},{"key":"R15","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0042-6822(92)90535-W","article-title":"A constitutively expressed vaccinia gene encodes a 42-kDa glycoprotein related to complement control factors that forms part of the extracellular virus envelope","volume":"188","author":"Engelstad","year":"1992","journal-title":"Virology"},{"key":"R16","first-page":"471","article-title":"Maximum-likelihood estimation of evolutionary trees from continuous characters","volume":"25","author":"Felsenstein","year":"1973","journal-title":"Am J Hum Genet"},{"key":"R17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1558-5646.1984.tb00255.x","article-title":"Distance methods for inferring phylogenies: a justification","volume":"38","author":"Felsenstein","year":"1984","journal-title":"Evolution"},{"key":"R18","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1558-5646.1985.tb00420.x","article-title":"Confidence limits on phylogenies: an approach using the bootstrap","volume":"39","author":"Felsenstein","year":"1985","journal-title":"Evolution"},{"key":"R19","first-page":"164","article-title":"phylip \u2013 Phylogeny Inference Package (Version 3.2)","volume":"5","author":"Felsenstein","year":"1989","journal-title":"Cladistics"},{"key":"R20","volume-title":"Smallpox and its Eradication","author":"Fenner","year":"1988"},{"key":"R21","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0042-6822(90)90294-2","article-title":"The complete DNA sequence of vaccinia virus","volume":"179","author":"Goebel","year":"1990","journal-title":"Virology"},{"key":"R22","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1099\/0022-1317-83-4-855","article-title":"The sequence of camelpox virus shows it is most closely related to variola virus, the cause of smallpox","volume":"83","author":"Gubser","year":"2002","journal-title":"J Gen Virol"},{"key":"R23","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1093\/sysbio\/45.1.92","article-title":"A likelihood ratio test to detect conflicting phylogenetic signal","volume":"45","author":"Huelsenbeck","year":"1996","journal-title":"Syst Biol"},{"key":"R24","first-page":"275","article-title":"The rapid generation of mutation data matrices from protein sequences","volume":"8","author":"Jones","year":"1992","journal-title":"Comput Appl Biosci"},{"key":"R25","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1099\/0022-1317-73-3-549","article-title":"A vaccinia serine protease inhibitor which prevents virus induced cell fusion","volume":"73","author":"Law","year":"1992","journal-title":"J Gen Virol"},{"key":"R26","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1006\/viro.2000.0761","article-title":"The genome sequence of Yaba-like disease virus, a yatapoxvirus","volume":"281","author":"Lee","year":"2001","journal-title":"Virology"},{"key":"R27","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/viro.1994.1288","article-title":"Analysis of the complete genome of smallpox variola major virus strain Bangladesh-1975","volume":"201","author":"Massung","year":"1994","journal-title":"Virology"},{"key":"R28","doi-asserted-by":"crossref","first-page":"4105","DOI":"10.1093\/nar\/18.14.4105","article-title":"Protein sequence comparisons show that the \u2018pseudoproteases' encoded by poxviruses and certain retroviruses belong to the deoxyuridine triphosphatase family","volume":"18","author":"McGeoch","year":"1990","journal-title":"Nucleic Acids Res"},{"key":"R29","doi-asserted-by":"crossref","first-page":"10401","DOI":"10.1128\/JVI.74.22.10401-10406.2000","article-title":"Toward a comprehensive phylogeny for mammalian and avian herpesviruses","volume":"74","author":"McGeoch","year":"2000","journal-title":"J Virol"},{"key":"R30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0042-6822(87)90307-2","article-title":"The structure and cloning of orf virus DNA","volume":"157","author":"Mercer","year":"1987","journal-title":"Virology"},{"key":"R31","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1099\/0022-1317-72-5-1031","article-title":"Mapping of deletions in the genome of the highly attenuated vaccinia virus MVA and their influence on virulence","volume":"72","author":"Meyer","year":"1991","journal-title":"J Gen Virol"},{"key":"R32","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/bioinformatics\/15.3.211","article-title":"dialign 2: improvement of the segment-to-segment approach to multiple sequence alignment","volume":"15","author":"Morgenstern","year":"1999","journal-title":"Bioinformatics"},{"key":"R33","first-page":"2849","article-title":"Poxviridae : the viruses and their replication","volume-title":"In Fields Virology","author":"Moss","year":"2001"},{"key":"R34","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0042-6822(90)90296-4","article-title":"Vaccinia virus host range genes","volume":"179","author":"Perkus","year":"1990","journal-title":"Virology"},{"key":"R35","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/0042-6822(91)90047-F","article-title":"Deletion of 55 open reading frames from the termini of vaccinia virus","volume":"180","author":"Perkus","year":"1991","journal-title":"Virology"},{"key":"R36","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/bioinformatics\/14.9.817","article-title":"modeltest: testing the model of DNA substitution","volume":"14","author":"Posada","year":"1998","journal-title":"Bioinformatics"},{"key":"R37","article-title":"SimPlot for Windows 95\/NT, version 1.2.2","author":"Ray","year":"1997"},{"key":"R38","first-page":"406","article-title":"The neighbor-joining method: a new method for reconstructing phylogenetic trees","volume":"4","author":"Saitou","year":"1987","journal-title":"Mol Biol Evol"},{"key":"R39","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1126\/science.273.5276.813","article-title":"Genome sequence of a human tumorigenic poxvirus: prediction of specific host response-evasion genes","volume":"273","author":"Senkevich","year":"1996","journal-title":"Science"},{"key":"R40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0168-1702(94)00113-Q","article-title":"Comparison of the genome DNA sequences of Bangladesh-1975 and India-1967 variola viruses","volume":"36","author":"Shchelkunov","year":"1995","journal-title":"Virus Res"},{"key":"R41","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1006\/viro.1998.9039","article-title":"The genomic sequence analysis of the left and right species-specific terminal region of a cowpox virus strain reveals unique sequences and a cluster of intact ORFs for immunomodulatory and host range proteins","volume":"243","author":"Shchelkunov","year":"1998","journal-title":"Virology"},{"key":"R42","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1006\/viro.1999.0086","article-title":"Alastrim smallpox variola minor virus genome DNA sequences","volume":"266","author":"Shchelkunov","year":"2000","journal-title":"Virology"},{"key":"R43","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0014-5793(01)03144-1","article-title":"Human monkeypox and smallpox viruses: genomic comparison","volume":"509","author":"Shchelkunov","year":"2001","journal-title":"FEBS Lett"},{"key":"R44","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0042-6822(86)90309-0","article-title":"Nucleotide sequence of the vaccinia virus hemagglutinin gene","volume":"150","author":"Shida","year":"1986","journal-title":"Virology"},{"key":"R45","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1128\/JVI.62.2.519-527.1988","article-title":"Vaccinia virus-encoded ribonucleotide reductase: sequence conservation of the gene for the small subunit and its amplification in hydroxyurea-resistant mutants","volume":"62","author":"Slabaugh","year":"1988","journal-title":"J Virol"},{"key":"R46","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0378-1119(83)90163-4","article-title":"Infectious poxvirus vectors have capacity for at least 25\u200a000 base pairs of foreign DNA","volume":"25","author":"Smith","year":"1983","journal-title":"Gene"},{"key":"R47","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1099\/0022-1317-72-6-1349","article-title":"Nucleotide sequence of 42\u2005kbp of vaccinia virus strain WR from near the right inverted terminal repeat","volume":"72","author":"Smith","year":"1991","journal-title":"J Gen Virol"},{"key":"R48","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1093\/oxfordjournals.molbev.a025664","article-title":"Quartet puzzling: a quartet maximum likelihood method for reconstructing tree topologies","volume":"13","author":"Strimmer","year":"1996","journal-title":"Mol Biol Evol"},{"key":"R49","article-title":"paup*. Phylogenetic Analysis Using Parsimony (*and Other Methods)","volume":"4","author":"Swofford","year":"2003","journal-title":"Version"},{"key":"R50","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1099\/0022-1317-83-8-1953","article-title":"A study of the vaccinia virus interferon-\u03b3 receptor and its contribution to virus virulence","volume":"83","author":"Symons","year":"2002","journal-title":"J Gen Virol"},{"key":"R51","first-page":"19","article-title":"Improved sensitivity of profile searches through the use of sequence weights and gap excision","volume":"10","author":"Thompson","year":"1994","journal-title":"Comput Appl Biosci"},{"key":"R52","doi-asserted-by":"crossref","first-page":"7122","DOI":"10.1128\/JVI.75.15.7122-7130.2001","article-title":"Genome of lumpy skin disease virus","volume":"75","author":"Tulman","year":"2001","journal-title":"J Virol"},{"key":"R53","doi-asserted-by":"crossref","first-page":"6054","DOI":"10.1128\/JVI.76.12.6054-6061.2002","article-title":"The genomes of sheeppox and goatpox viruses","volume":"76","author":"Tulman","year":"2002","journal-title":"J Virol"},{"key":"R54","doi-asserted-by":"crossref","first-page":"7590","DOI":"10.1128\/JVI.77.13.7590-7600.2003","article-title":"Poxvirus orthologous clusters: towards defining the minimum essential poxvirus genome","volume":"77","author":"Upton","year":"2003","journal-title":"J Virol"},{"key":"R55","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1099\/0022-1317-83-1-195","article-title":"The vaccinia virus F12L is associated with intracellular enveloped virus particles and is required for their egress to the cell surface","volume":"83","author":"van Eijl","year":"2002","journal-title":"J Gen Virol"},{"key":"R56","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1006\/viro.1999.0002","article-title":"The complete genome sequence of shope (rabbit) fibroma virus","volume":"264","author":"Willer","year":"1999","journal-title":"Virology"}],"container-title":["Journal of General Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jgv\/10.1099\/vir.0.19565-0?crawler=true","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T17:09:20Z","timestamp":1583255360000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.microbiologyresearch.org\/content\/journal\/jgv\/10.1099\/vir.0.19565-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1,1]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,1,1]]}},"URL":"https:\/\/doi.org\/10.1099\/vir.0.19565-0","relation":{},"ISSN":["0022-1317","1465-2099"],"issn-type":[{"value":"0022-1317","type":"print"},{"value":"1465-2099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,1,1]]}}}